Mapping of epitopes on the BP180 ectodomain targeted by IgA and IgG autoantibodies in patients with the lamina lucida-type of linear IgA disease

Archives of Dermatological Research

Volumn 293, Issue 3, 2001, Pages 109-114

  Georgi, Matthias ^a   Scheckenbach, Christian ^a   Kromminga, Arno ^b   Partscht, Karin ^c   Messer, Gerald ^c   Brocker E B ^a   Zillikens, D ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Inst Immunol   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Autoantibodies; Cicatricial pemphigoid; Dermoepidermal junction; Linear IgA disease

Indexed keywords

AUTOANTIBODY; EPITOPE; HYBRID PROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; PROTEIN; PROTEIN BP180; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; AUTOIMMUNE DISEASE; BLISTER; BULLOUS SKIN DISEASE; CLINICAL ARTICLE; DERMOEPIDERMAL JUNCTION; FEMALE; HUMAN; IMMUNOGLOBULIN DEPOSITION; MALE; MUCOUS MEMBRANE PEMPHIGOID; PEMPHIGOID; PRIORITY JOURNAL; PROTEIN DOMAIN;

ADULT; AGED; AGED, 80 AND OVER; AUTOANTIBODIES; AUTOANTIGENS; EPITOPE MAPPING; FEMALE; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; PROTEIN STRUCTURE, TERTIARY; SKIN DISEASES, VESICULOBULLOUS;

EID: 0035088443     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004030000205     Document Type: Article

References (33)

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5. IgG, IgA and IgE autoantibodies against the ectodomain of BP180 in patients with bullous and cicatricial pemphigoid and linear IgA bullous dermatosis
6. Patients with bullous pemphigoid and linear IgA disease show a dual IgA and IgG autoimmune response to BP180
7. Immunoelectron microscopic studies in IgA linear dermatosis
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9. Use of 1M NaCl split skin in the indirect immunofluorescence of the linear IgA bullous dermatoses
10. Immunoblotting studies of linear IgA disease
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14. LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120-kDa anchoring filament protein synthesized by epidermal cells
15. Linear IgA bullous dermatosis with IgA antibodies exclusively directed against the 180- or 230-kDa epidermal antigens
16. BP180/type XVII collagen: Its role in acquired and inherited disorders of the dermal-epidermal junction
17. The 97 kDa linear IgA bullous disease antigen is identical to a portion of the extracellular domain of the 180 kDa bullous pemphigoid antigen, BPAg2
18. Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide
19. Two forms of collagen XVII in keratinocytes. A full-length transmembrane protein and a soluble ectodomain
20. Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies
21. 3 are the major immunoglobulin subclasses targeting epitopes within the NC16A domain of BP180 in pemphigoid gestationis
22. Cicatricial pemphigoid autoantibodies react with multiple sites on the BP180 extracellular domain
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24. IgA antibodies of cicatricial pemphigoid sera specifically react with C-terminus of BP180
25. Autoantibodies in lichen planus pemphigoides react with a novel epitope within the C-terminal NC16A domain of BP180
26. Autoantibodies in a subgroup of patients with linear IgA disease react with the NC16A domain of BP180
27. A novel subepidermal blistering disease with autoantibodies to a 200-kDa antigen of the basement membrane zone
28. Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180
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30. The shed ectodomain of collagen XVII/BP180 is targeted by autoantibodies in different blistering skin diseases
31. The extracellular domain of BPAG2 localizes to anchoring filaments and its carboxyl terminus extends to the lamina densa of normal human epidermal basement membrane
32. Ultrastructural immunogold studies in two cases of linear IgA dermatosis. Are there two distinct types of this disease?
33. Mucous membrane pemphigoid: A dual circulating antibody response with IgG and IgA signifies a more severe and persistent disease