IgG, IgA and IgE autoantibodies against the ectodomain of BP180 in patients with bullous and cicatricial pemphigoid and linear IgA bullous dermatosis

British Journal of Dermatology

Volumn 143, Issue 2, 2000, Pages 349-355

  Christophoridis, S ^a   Budinger L ^a   Borradori, L ^b   Hunziker, T ^c   Merk, H F ^a   Hertl, M ^a,d  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Autoimmunity; B lymphocytes; BP180; Bullous pemphigoid; Cicatricial pemphigoid; Epitope; Hemidesmosomes; Immunoglobulin subtypes; Linear IgA bullous dermatosis

Indexed keywords

COLLAGEN TYPE 17; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G ANTIBODY;

ADULT; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BASEMENT MEMBRANE; BULLOUS SKIN DISEASE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; HEMIDESMOSOME; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; MUCOUS MEMBRANE PEMPHIGOID; PEMPHIGOID; PRIORITY JOURNAL;

ADULT; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; PEMPHIGOID, BENIGN MUCOUS MEMBRANE; PEMPHIGOID, BULLOUS;

EID: 0033842377     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.2000.03661.x     Document Type: Article

References (32)

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2. Characterization of bullous pemphigoid antigen: A unique basement membrane protein of stratified squamous epithelia
3. Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting
4. A 230-kD basic protein is the major bullous pemphigoid antigen
5. An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments
6. Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180
7. The extracellular domain of BPAG2 localizes to anchoring filaments and its carboxy terminus extends to the lamina densa of normal human epidermal basement membrane
8. The extracellular domain of BP180 binds laminin 5
9. A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180
10. Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies
11. IgG autoantibodies from bullous pemphigoid (BP) patients bind antigenic sites on both the extracellular and the intracellular domains of the BP antigen 180
12. Immunoreactivity of bullous pemphigoid (BP) autoantibodies against the NC16A and C-terminal domains of the 180 kDa BP antigen (BP180): Immunoblot analysis and enzyme-linked immunosorbent assay using BP180 recombinant proteins
13. Cicatricial pemphigoid autoantibodies react with multiple sites on the BP180 extracellular domain
14. Anti-basement membrane autoantibodies in patients with anti-epiligrin cicatricial pemphigoid bind the alpha subunit of laminin 5
15. Anti-epiligrin cicatricial pemphigoid with IgG autoantibodies to the beta and gamma subunits of laminin 5
16. Identification of the cutaneous basement membrane zone antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis
17. Identification of the target antigen in chronic bullous disease of childhood and linear IgA disease of adults
18. Dermatose bulleuse a IgA lineaire de l'enfant avec autoanticorps diriges contre l'antigene 180 kDa de la pemphigoide
19. A case of linear IgA bullous dermatosis with IgA anti-type VII collagen autoantibodies
20. Linear IgA bullous dermatosis with IgA antibodies exclusively directed against the 180- and 230-kDa epidermal antigens
21. The 97 kDa linear IgA bullous disease antigen is identical to a portion of the extracellular domain of the 180 kDa bullous pemphigoid antigen. BPAG2
22. Antigenic specificity of antibodies from patients with linear basement membrane deposition of IgA
23. Autoimmune responses of linear IgA disease: Both T cells and autoantibodies recognize the NC16A domain of BP180
24. Detection of IgG autoantibodies in the sera of patients with bullous and gestational pemphigoid: ELISA studies utilizing a baculovirus-encoded form of bullous pemphigoid antigen 2
25. Linear IgA bullous dermatosis: Characterization of a subset of patients with concurrent IgA and IgG anti-basement membrane autoantibodies
26. A child with antibodies targeting both linear IgA bullous dermatosis and bullous pemphigoid antigens
27. IgG and IgA antibodies in linear IgA/IgG bullous dermatosis target the ectodomain of bullous pemphigoid antigen 2
28. IgA antibodies of cicatricial pemphigoid sera specifically react with C-terminus of BP180
29. Mucous membrane pemphigoid: A dual circulating antibody response with IgG and IgA signifies a more severe and persistent disease
30. The immunoglobulin A antibody response in clinical subsets of mucous membrane pemphigoid
31. IgA basement membrane zone autoantibodies in bullous pemphigoid detect epidermal antigens of 270-280 kDa. 230 kDa and 180 kDa molecular weight by immunoblotting
32. IgE autoantibodies directed against the major bullous pemphigoid antigen in patients with a severe form of pemphigoid