-
1
-
-
0033616590
-
Unusual phenotypic alteration of β amyloid precursor protein (βAPP) maturation by a new Val-715→Met βAPP-770 mutation responsible for probable early-onset Alzheimer's disease
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 4119-4124
-
-
Ancolio, K.1
Dumanchin, C.2
Barelli, H.3
Warter, J.M.4
Brice, A.5
Campion, D.6
Frebourg, T.7
Checler, F.8
-
2
-
-
9544219691
-
Polymorphism at codon 129 or codon 219 of PRNP and clinical heterogeneity in a previously unreported family with Gerstmann-Sträussler-Scheinker disease (PrP-P102L mutation)
-
(1996)
Neurology
, vol.47
, pp. 734-741
-
-
Barbanti, P.1
Fabbrini, G.2
Salvatore, M.3
Macchi, G.4
Lenzi, G.L.5
Poccriari, M.6
Petraroli, R.7
Cardone, F.8
Maras, B.9
Equestre, M.10
-
5
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42, 1-40 ratio in vitro and vivo
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
-
10
-
-
0025991466
-
The scrapie-associated form of PrP is made from a cell surface precursor that is both protease-and phospholipase-sensitive
-
(1991)
J Biol Chem
, vol.266
, pp. 18217-18223
-
-
Caughey, B.1
Raymond, G.J.2
-
15
-
-
0031949628
-
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
-
(1998)
Nat Med
, vol.4
, pp. 452-455
-
-
Crook, R.1
Verkkoniemi, A.2
Perez-Tur, J.3
Mehta, N.4
Baker, M.5
Houlden, H.6
Farrer, M.7
Hutton, M.8
Lincoln, S.9
Hardy, J.10
Gwinn, K.11
Somer, M.12
Paetau, A.13
Kalimo, H.14
Ylikoski, R.15
Poyhonen, M.16
Kucera, S.17
Haltia, M.18
-
16
-
-
0031456947
-
Structure of the recombinant full-length hamster prion protein PrP (29-231): The N terminus is highly flexible
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13452-13457
-
-
Donne, D.G.1
Viles, J.H.2
Groth, D.3
Mehlhorn, I.4
James, T.L.5
Cohen, F.E.6
Prusiner, S.B.7
Wright, P.E.8
Dyson, J.H.9
-
17
-
-
0033780472
-
Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
-
(2000)
Nat Cell Biol
, vol.2
, pp. 1-7
-
-
Esler, W.P.1
Kimberly, W.T.2
Ostaszewski, B.L.3
Diehl, T.S.4
Moore, C.L.5
Tsai, J.Y.6
Rahmati, T.7
Xia, W.8
Selkoe, D.J.9
Wolfe, M.S.10
-
19
-
-
0026496257
-
Fatal familial insomnia and Familial Creutzfeldt Jakob disease: Disease phenotype determined by a DNA polymorphism
-
(1992)
Science
, vol.258
, pp. 806-808
-
-
Goldfarb, L.G.1
Petersen, R.B.2
Tabaton, M.3
Brown, P.4
LeBlanc, A.C.5
Montagna, P.6
Cortelli, P.7
Julien, J.8
Vital, C.9
Pendlebury, W.W.10
Haltia, M.11
Willis, P.R.12
Hauw, J.J.13
McKeever, P.E.14
Monari, L.15
Schrank, B.16
Swergold, G.D.17
Autilio-Gambetti, L.18
Gajdusek, C.19
Lugaresi, E.20
Gambetti, P.21
more..
-
21
-
-
0002442331
-
Klinische und anatomische Untersuchungen über eine eigenartige organische Erkrankung des Zentralnervensystems im Praesenium
-
(1929)
Z Gesamte Neurol Psychiat
, vol.18
, pp. 49-114
-
-
Heidenhain, A.1
-
23
-
-
0027195933
-
Seeding one-dimensional crystallization of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
-
(1993)
Cell
, vol.73
, pp. 1055-1058
-
-
Jarrett, J.T.1
Lansbury, P.T.2
-
24
-
-
0030613755
-
Sc)-specific epitope defined by a monoclonal antibody
-
(1997)
Nature
, vol.390
, pp. 74-77
-
-
Korth, C.1
Stierli, B.2
Streit, P.3
Moser, M.4
Schaller, O.5
Fischer, R.6
Schulz-Schaeffer, W.7
Kretzschmar, H.8
Raeber, A.9
Braun, U.10
Ehrensperger, F.11
Hornemann, S.12
Glockshuber, R.13
Riek, R.14
Billeter, M.15
Wuthrich, K.16
Oesch, B.17
-
25
-
-
0034621824
-
Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
-
(2000)
Nature
, vol.405
, pp. 689-694
-
-
Li, Y.M.1
Xu, M.2
Lai, M.T.3
Huang, Q.4
Catro, J.L.5
DiMuzio-Mower, J.6
Harrison, T.7
Lellis, C.8
Nadin, A.9
Neduvelil, J.G.10
Register, R.B.11
Sardana, M.K.12
Shearman, M.S.13
Smith, A.L.14
Shi, X.P.15
Yin, K.C.16
Shafer, J.A.17
Gardeli, S.J.18
-
26
-
-
9044239670
-
Familial and sporadic Alzheimer's disease: Neuropathology cannot exclude a final common pathway
-
(1996)
Neurology
, vol.46
, pp. 406-412
-
-
Lippa, C.F.1
Saunders, A.M.2
Smith, T.W.3
Swearer, J.M.4
Drachman, D.A.5
Ghetti, B.6
Nee, L.7
Pulaski-Salo, D.8
Dickson, D.9
Robitaille, Y.10
Bergeron, C.11
Brain, B.12
Benson, M.D.13
Farlow, M.14
Hyman, B.T.15
St. George-Hyslop, P.16
Roses, A.D.17
Pollen, D.A.18
-
27
-
-
0033609035
-
Solution structure of Syrian hamster prion protein
-
(1999)
Biochemistry
, vol.27
, Issue.38
, pp. 5362-5377
-
-
Liu, H.1
Farr-Jones, S.2
Ulyanov, N.B.3
Llinas, M.4
Marqusee, S.5
Groth, D.6
Cohen, F.E.7
Prusiner, S.B.8
James, T.L.9
-
28
-
-
0028351904
-
Fatal Familial Insomnia and Familial Creutzfeldt-Jakob disease: Different prion proteins determined by a DNA polymorphism
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 2839-2842
-
-
Monari, L.1
Chen, S.C.2
Brown, P.3
Parchi, P.4
Petersen, R.B.5
Mikol, J.6
Gray, F.7
Cortelli, P.8
Montagna, P.9
Ghetti, B.10
Goldfarb, L.G.11
Gajdusek, D.C.12
Lugaresi, E.13
Gambetti, P.14
Autilio-Gambetti, L.15
-
29
-
-
0027332116
-
Conversion of α-helices into β-sheets features in the formation of the scrapie prion proteins
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 10962-10966
-
-
Pan, K.M.1
Baldwin, M.2
Nguyen, J.3
Gasset, M.4
Serban, A.5
Groth, D.6
Mehlhorn, I.7
Huang, Z.8
Fletterick, R.J.9
Cohen, F.E.10
Prusiner, S.B.11
-
30
-
-
0030953939
-
Typing prion isoforms
-
(1997)
Nature
, vol.386
, pp. 232-233
-
-
Parchi, P.1
Capellari, S.2
Chen, S.G.3
Petersen, R.B.4
Gambetti, P.5
Kopp, N.6
Brown, P.7
Kitamoto, T.8
Tateishi, J.9
Giese, A.10
Kretzschmar, H.11
-
31
-
-
0032976574
-
A subtype of sporadic prion disease mimicking fatal familial insomnia
-
(1999)
Neurology
, vol.52
, pp. 1757-1763
-
-
Parchi, P.1
Capellari, S.2
Chin, S.3
Schwartz, H.B.4
Schecter, N.P.5
Butts, J.D.6
Hudkins, P.7
Burns, D.K.8
Powers, J.M.9
Gambetti, P.10
-
32
-
-
8944259890
-
Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease
-
(1996)
Ann Neurol
, vol.39
, pp. 767-778
-
-
Parchi, P.1
Castellani, R.2
Capellari, S.3
Ghetti, B.4
Young, K.5
Chen, S.G.6
Farlow, M.7
Dickson, D.W.8
Sima, A.A.F.9
Trojanowski, J.Q.10
Petersen, R.B.11
Gambetti, P.12
-
34
-
-
0032816292
-
Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects
-
(1999)
Annals of Neurology
, vol.46
, pp. 224-133
-
-
Parchi, P.1
Giese, A.2
Capellari, S.3
Brown, P.4
Schulz-Schaeffer, W.5
Windl, O.6
Zerr, I.7
Budka, H.8
Kopp, N.9
Piccardo, P.10
Poser, S.11
Rojiani, A.12
Streichemberger, N.13
Julien, J.14
Vital, C.15
Ghetti, B.16
Gambetti, P.17
Kretzschmar, H.18
-
35
-
-
12944253111
-
Genetic influence on structural variations of the abnormal prion protein
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10168-10172
-
-
Parchi, P.1
Zou, W.Q.2
Capellari, S.3
Brown, P.4
Wang, W.5
Ghetti, B.6
Kopp, N.7
Schulz-Schaeffer, W.8
Kretzschmar, H.9
Head, M.W.10
Ironside, J.W.11
Gambetti, P.12
Chen, S.G.13
-
38
-
-
13044309464
-
Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15598-15602
-
-
Russo, C.1
Angelini, G.2
Dapino, D.3
Piccini, A.4
Piombo, G.5
Schettini, G.6
Chen, S.7
Teller, J.K.8
Zaccheo, D.9
Gambetti, P.10
Tabaton, M.11
-
40
-
-
18744435477
-
Presenilin-1 mutations in Alzheimer's disease
-
(2000)
Nature
, vol.405
, pp. 531-532
-
-
Russo, C.1
Schettini, G.2
Saido, T.C.3
Hulette, C.4
Lippa, C.5
Lannfelt, L.6
Ghetti, B.7
Gambetti, P.8
Tabaton, M.9
Teller, J.K.10
-
46
-
-
13344293701
-
Presence of soluble β-peptide precedes amyloid plaques formation in Down's syndrome
-
(1996)
Nature Med
, vol.2
, pp. 93-95
-
-
Teller, J.K.1
Russo, C.2
De Busk, L.3
Angelini, G.4
Zaccheo, D.5
Dagna-Bricarelli, F.6
Scartezzini, P.7
Bertolini, S.8
Mann, D.M.A.9
Tabaton, M.10
Gambetti, P.11
-
51
-
-
0034255029
-
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9299-9304
-
-
Xia, W.1
Ray, W.J.2
Ostaszewski, B.L.3
Rahmati, T.4
Kimberly, W.T.5
Wolfe, M.S.6
Zhang, J.7
Goate, A.M.8
Selkoe, D.J.9
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