Screening for selective thrombin inhibitors in mushrooms

Blood Coagulation and Fibrinolysis

Volumn 12, Issue 2, 2001, Pages 123-128

  Doljak, Bojan ^a   Stegnar, M ^b   Urleb, U ^a   Kreft, S ^a   Umek, A ^a   Ciglaric M ^a   Strukelj B ^a,c   Popoviv T ^c  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^c JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

Extract; Fungi; Inhibitor; Mushrooms; Screening; Thrombin

Indexed keywords

AMANITA VIROSA EXTRACT; BENZOYLARGININE 4 NITROANILIDE; CANTHARELLUS LUTESCENS EXTRACT; CLITOCYBE GIBBA EXTRACT; DEXTRO PHENYLALANYLPIPECOLYLARGININE 4 NITROANILIDE; GLEOPHYLLUM ODORATUM EXTRACT; HYPOLOMA FASCICULARE EXTRACT; LACTARIUS BADIOSANGUINEUS EXTRACT; PLANT EXTRACT; SERINE PROTEINASE; SUILLUS TRIDENTINUS EXTRACT; THROMBIN; THROMBIN INHIBITOR; TRYPSIN; UNCLASSIFIED DRUG;

ANTICOAGULANT THERAPY; ARTICLE; BASIDIOMYCETES; BLOOD CLOT LYSIS; BLOOD CLOTTING; DRUG EFFECT; DRUG MECHANISM; DRUG SAFETY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME ISOLATION; INHIBITION KINETICS; MUSHROOM; NONHUMAN; PRIORITY JOURNAL;

AGARICALES; BASIDIOMYCOTA; BENZOYLARGININE NITROANILIDE; CHROMOGENIC COMPOUNDS; DIPEPTIDES; PLANT EXTRACTS; SPECIES SPECIFICITY; THROMBIN; TRYPSIN; TRYPSIN INHIBITORS;

EID: 0035084552     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-200103000-00006     Document Type: Article

References (15)

1. Neue Wirkstoffe aus Basidiomyceten - New active substances from Basidiomycetes
2. Cysteine proteinase inhibitiors screening of fungal species growing in Slovenia
3. Screening of selected Basidiomycetes for inhibitory activity on neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE)
4. Strategies and progress towards the ideal orally active thrombin inhibitor
5. Thrombin (CLAN SA-S1)
6. Diarylsulfonamides as selective, non-peptidic thrombin inhibitors
7. Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: Implications for drug design
8. Identification of glycyrrhizin as a thrombin inhibitor
9. Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade
10. Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: Mechanism of action and structural studies
11. Untersuchungen zur inhibitorischen wirkung von wässrigen extrakten aus basidiomyceten auf trypsin
12. Trypsininhibitoreaktivität in basidiomyceten
13. The inhibitory properties and primary structure of a novel serine proteinase inhibitor from the fruiting body of the basidiomycete, Lentinus edodes
14. Thrombin inhibitors as antithrombotic agents: The importance of rapid inhibition
15. Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy