Heterogeneity of p53 mutational status in intramucosal carcinoma of tha colorectum

Japanese Journal of Cancer Research

Volumn 92, Issue 2, 2001, Pages 161-166

  Yamada, Satoshi ^a   Ajioka, Yoichi ^a   Watanabe, Hidenobu ^a   Hashidate, Hideki ^a   Takaku, Hideya ^a   Kazama, Shinsuke ^a   Yokoyama, Junji ^a   Nishikura, Ken ^a   Fujiwara, Takato ^a   Asakura, Hitoshi ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

Colorectal carcinoma; Heterogeneity; Intramucosal carcinoma; P53 gene

Indexed keywords

PROTEIN P53;

ARTICLE; CANCER STAGING; CLINICAL ARTICLE; CODON; COLON MUCOSA; COLORECTAL CARCINOMA; CONTROLLED STUDY; ENDOSCOPIC SURGERY; EXON; GENE MUTATION; GENE SEQUENCE; GENETIC HETEROGENEITY; HUMAN; HUMAN TISSUE; HYPOTHESIS; INVASIVE CARCINOMA; MOLECULAR CLONING; PRIORITY JOURNAL; RECTUM MUCOSA; SEQUENCE ANALYSIS; SUBMUCOSA; TUMOR SUPPRESSOR GENE;

CARCINOMA; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; GENES, P53; HUMANS; INTESTINAL MUCOSA; MUTATION; TUMOR SUPPRESSOR PROTEIN P53; VARIATION (GENETICS);

EID: 0035081568     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2001.tb01078.x     Document Type: Article

References (31)

1. A genetic model for colorectal tumorigenesis
2. Genetic alterations during colorectal-tumor development
3. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
4. Identification of FAP locus genes from chromosome 5q21
5. Identification of a chromosome 18q gene that is altered in colorectal cancers
6. Mutations in the p53 gene occur in diverse human tumor types
7. p53 mutations in human cancers
8. Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients
9. Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas
10. Somatic mutations detected by mini- and microsatellite DNA markers reveal clonal intratumor heterogeneity in gastrointestinal cancers
11. Clonal analysis of colorectal tumors using K-ras and p53 gene mutations as markers
12. Mutation of p53 gene precedes aneuploid clonal divergence in colorectal carcinoma
13. Relationship between DNA heterogeneity and genetic alterations in colorectal carcinomas
14. A frequent alteration of p53 gene in carcinoma in adenoma of colon
15. Alteration of p53 clonality accompanying colorectal cancer progression
16. Relationship of colorectal adenoma and colorectal carcinoma: Based on the author's diagnostic criteria
17. Effect of K-ras mutation on morphogenesis of colorectal adenomas and early cancers: Relationship to distribution of proliferating cells
18. The proliferating cell nuclear antigen (PCNA) index correlates with the grade of cytologic atypia in well-differentiated early adenocarcinomas of the large intestine
19. p53 immunostaining distinguishes malignant from benign lesions of the gall-bladder
20. Archival analysis of p53 protein overexpression and genetic mutation in esophageal squamous cell carcinoma
21. p53 accumulation in colorectal cancer with hepatic metastasis
22. Microdissection and polymerase chain reaction amplification of genomic DNA from histological tissue sections
23. The clonal evolution of tumor cell populations
24. A detailed analysis of the role of K-ras gene mutation in the progression of colorectal adenoma
25. Heterogeneity of mutant versus wild-type Ki-ras in primary and metastatic colorectal carcinomas, and association of codon-12 valine with early mortality
26. Genetic heterogeneity in sporadic colorectal adenomas
27. Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas
28. Intratumoral regional heterogeneity of DNA ploidy patterns in colorectal carcinomas
29. Microsatellite instability in young patients with colorectal cancer
30. Importance of grade of cytological atypia for well differentiated adenocarcinoma of the colo-rectum