Molecular organization of the genes required for the synthesis of type 1 capsular polysaccharide of Streptococcus pneumoniae: Formation of binary encapsulated pneumococci and identification of cryptic dTDP-rhamnose biosynthesis genes

Molecular Microbiology

Volumn 25, Issue 1, 1997, Pages 79-92

  Muñoz, Rosario ^a   Mollerach, Marta ^a,b   López, Rubens ^a   García, Ernesto ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL POLYSACCHARIDE; RHAMNOSE; THYMIDINE DIPHOSPHATE;

ARTICLE; BACTERIAL MEMBRANE; GENE LOCUS; GENE STRUCTURE; GENETIC ORGANIZATION; MEMBRANE FORMATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; STREPTOCOCCUS PNEUMONIAE;

ALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PNEUMOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

EID: 0030748254     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1997.4341801.x     Document Type: Article

References (39)

1. Arrecubieta, C., López, R., and García, E. (1994) Molecular characterization of cap3A, a gene from the operon required for the synthesis of the capsule of Streptococcus pneumoniae type 3: sequencing of mutations responsible for the unencapsulated phenotype and localization of the capsular cluster on the pneumococcal chromosome. J Bacteriol 176: 6375-6383.
2. Arrecubieta, C., García, E., and López, R. (1995) Sequence and transcriptional analysis of a DNA region involved in the production of capsular polysaccharide in Streptococcus pneumoniae type 3. Gene 167: 1-7.
3. Arrecubieta, C., García, E., and López, R. (1996a) Demonstration of UDP-glucose dehydrogenase activity in cell extracts of Escherichia coli expressing the pneumococcal cap3A gene required for the synthesis of type 3 capsular polysaccharide. J Bacteriol 178: 2971-2974.
4. Arrecubieta, C., López, R., and García, E. (1996b) Type 3-specific synthase of Streptococcus pneumonias (Cap3B) directs type 3 polysaccharide biosynthesis in Escherichia coli and in pneumococcal strains of different serotypes. J Exp Med 184: 449-455.
5. Austrian, R., and Bernheimer, H.P. (1959) Simultaneous production of two capsular polysaccharides by pneumococcus. I. Properties of a pneumococcus manifesting binary capsulation. J Exp Med 110: 571-584.
6. Austrian, R., Bernheimer, H.P., Smith, E.E.B., and Mills, G.T. (1959) Simultaneous production of two capsular polysaccharides by pneumococcus. II. The genetic and biochemical bases of binary capsulation. J Exp Med 110: 585-602.
7. Avery, O.T., MacLeod, C.M., and McCarty, M. (1944) Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a deoxyribonucleic acid fraction isolated from pneumococcus type III. J Exp Med 79: 137-158.
8. Behr, T., Fischer, W., Peter-Katalinic, J., and Egge, H. (1992) The structure of pneumococcal lipoteichoic acid. Improved preparation, chemical and mass spectrometric studies. Eur J Biochem 207: 1063-1075.
9. Bernheimer, H.P., and Wermundsen, I.E. (1969) Unstable binary capsulated transformants in pneumococcus. J Bacteriol 98: 1073-1079.
10. Bernheimer, H.P., and Wermundsen, I.E. (1972) Homology in capsular transformation reactions in Pneumococcus. Mol Gen Genet 116: 68-83.
11. Díaz, E., and García, J.L. (1990) Construction of a broad-host-range pneumococcal promoter-probe plasmid. Gene 90: 163-167.
12. Dillard, J.P., and Yother, J. (1991) Analysis of Streptococcus pneumoniae sequences cloned into Escherichia coli: effect of promoter strength and transcription terminators. J Bacteriol 173: 5105-5109.
13. Dillard, J., Vandersea, M.W., and Yother, J. (1995) Characterization of the cassette containing genes for the type 3 capsular polysaccharide biosynthesis in Streptococcus pneumoniae. J Exp Med 181: 973-983.
14. Fischer, W., Behr, T., Hartmann, R., Peter-Katalinic, J., and Egge, H. (1993) Teichoic acid and lipoteichoic acid of Streptococcus pneumoniae possess identical chain structures. A reinvestigation of teichoic acid (C polysaccharide). Eur J Biochem 215: 851-857.
15. García, E., and López, R. (1997) Molecular biology of the capsular genes of Streptococcus pneumoniae. FEMS Microbiol Lett 149: 1-10.
16. García, E., García, P., and López, R. (1993) Cloning and sequencing of a gene involved in the synthesis of the capsular polysaccharide of Streptococcus pneumoniae type 3. Mol Gen Genet 239: 188-195.
17. Griffith, F. (1928) The significance of pneumococcal types. J Hyg 27: 113-159.
18. Guidolin, A., Morona, J.K., Morona, R., Hansman, D., and Paton, J.C. (1994) Nucleotide sequence analysis of genes essential for capsular polysaccharide biosynthesis in Streptococcus pneumoniae type 19F. Infect Immun 62: 5384-5396.
19. Guy, R.C.E., How, M.J., Stacey, M., and Heidelberger, M. (1967) The capsular polysaccharide of type 1 pneumococcus. I. Purification and chemical modification. J Biol Chem 242: 5106-5111.
20. Henrichsen, J. (1995) Six newly recognized types of Streptococcus pneumonias. J Clin Microbiol 33: 2759-2762.
21. Karakawa, W.W., Kane, J.A., and Austrian, R. (1974) Filamentous capsulated streptococci from the human respiratory tract. Infect Immun 8: 962-968.
22. Kroll, U.S., Loynds, B.M., and Moxon, E.R. (1991) The Haemophilus influenzae capsulation gene cluster: a compound transposon. Mol Microbiol 5: 1549-1560.
23. Lacks, S., and Hotchkiss, R.D. (1960) A study of the genetic material determining an enzyme activity in Pneumococcus. Biochim Biophys Acta 39: 508-517.
24. Lee, C.Y. (1995) Association of staphylococcal type-1 capsule-encoding genes with a discrete genetic element. Gene 167: 115-119.
25. Lindberg, B., Lindqvist, B., Lönngren, J., and Powell, D.A. (1980) Structural studies of the capsular polysaccharide from Streptococcus pneumoniae type 1. Carbohydr Res 78: 111-117.
26. Liu, H-W., and Thorson, J.S. (1994) Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria. Annu Rev Microbiol 48: 223-256.
27. Lund, E., and Henrichsen, J. (1978) Laboratory diagnosis, serology and epidemiology of Streptococcus pneumoniae. Meth Microbiol 12: 241-262.
28. Mäkelä, P.H., and Stocker, B.A.D. (1969) Genetics of polysaccharide biosynthesis. Annu Rev Genet 3: 291-322.
29. Martin, B., Humbert, O., Cámara, M., Guenzi, E., Walker, J., Mitchell, T., Andrew, P., Prudhomme, M., Alloing, G., Hakenbeck, R., Morrison, D.A., Boulnois, G.J., and Claverys, J.-P. (1992) A highly conserved repeated DNA element located in the chromosome of Streptococcus pneumoniae. Nucleic Acids Res 20: 3479-3483.
30. Mills, G.T., and Smith, E.E.B. (1965) Biosynthesis of capsular polysaccharides in the pneumococcus. Bull Soc Chim Biol 47: 1751-1765.
31. Morona, J.K., Guidolin, A., Morona, R., Hansman, D., and Paton, J.C. (1994) Isolation, characterization, and nucleotide sequence of IS1202, an insertion sequence of Streptococcus pneumoniae. J Bacteriol 176: 4437-4443.
32. Morona, J.K., Morona, R., and Paton, J.C. (1997) Characterization of the locus encoding the Streptococcus pneumoniae type 19F capsular polysaccharide biosynthetic pathway. Mol Microbiol 23: 751-763.
33. Petering, H., Hammerschmidt, S., Frosch, M., van Putten, J.P.M., Ison, C.A., and Robertson, B.D. (1996) Genes associated with the meningococcal capsule complex are also found in Neisseria gonorrhoeae. J Bacteriol 178: 3342-3345.
34. Romero, A., López, R., and García, P. (1990) Sequence of the Streptococcus pneumoniae bacteriophage HB-3 amidase reveals high homology with the major host autolysin. J Bacteriol 172: 5064-5070.
35. Ronda, C., García, J.L., and López, R. (1988) Characterization of genetic transformation in Streptococcus oralis NCTC 11427. Expression of pneumococcal amidase in S. oralis using a new shuttle vector. Mol Gen Genet 215: 53-57.
36. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. 2nd edn. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
37. Smith, E.E.B., Mills, G.T., Bernheimer, H.P., and Austrian, R. (1958) The presence of an uronic acid epimerase in a strain of pneumococcus type I. Biochim Biophys Acta 29: 640-641.
38. Xiang, S.-H., Hobbs, M., and Reeves, P.R. (1994) Molecular analysis of the rfb gene cluster of a group D2 Salmonella enterica strain: evidence for its origin from an insertion sequence-mediated recombination event between group E and D1 strains. J Bacteriol 176: 4357-4365.
39. Zhou, L., Hui, F.M., and Morrison, D.A. (1995) Characterization of IS1167, a new insertion sequence in Streptococcus pneumoniae. Plasmid 33: 127-138.