Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila

Journal of Neuroscience

Volumn 18, Issue 19, 1998, Pages 7662-7673

  Reist, Noreen E ^a   Buchanan, Joann ^b   Li, Jing ^b   DiAntonio, Aaron ^b   Buxton, Elizabeth M ^a   Schwarz, Thomas L ^b  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Drosophila; Electron microscopy; Synaptic vesicles; Synaptotagmin; Vesicle docking; Vesicle recycling

Indexed keywords

MUTANT PROTEIN; SYNAPTOTAGMIN;

ANIMAL CELL; ARTICLE; CELL ULTRASTRUCTURE; DROSOPHILA; ELECTRON MICROSCOPY; GENE MUTATION; MOTOR NERVE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SYNAPSE VESICLE;

EID: 0032188811     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-19-07662.1998     Document Type: Article

References (5)

1. Bale M, Martinez Arias A, Editors (1993) The development of Drosophila melanogaster. Plainview, NY: Cold Spring Harbor Laboratory.
2. Bennett MK, Calakos N, Scheller RH (1992) Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science 257:255-259.
3. Bommert K, Charlton MP, DeBello WM, Chin GJ, Betz H, Augustine GJ (1993) Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis. Nature 363:163-165.
4. Broadie K, Bellen HJ, DiAntonio A, Littleton JT, Schwarz TL (1994) Absence of synaptotagmin disrupts excitation - secretion coupling during synaptic transmission. Proc Natl Acad Sci USA 91:10727-10731.
5. Broadie K, Prokop A, Bellen HJ, O'Kane CJ, Schulze KL, Sweeney ST (1995) Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila. Neuron 15:663-673.