Within the hemopoietic system, LAR phosphatase is a T cell lineage-specific adhesion receptor-like protein whose phosphatase activity appears dispensable for T cell development, repertoire selection and function

European Journal of Immunology

Volumn 31, Issue 3, 2001, Pages 832-840

  Terszowski, Grzegorz ^a,b   Jankowski, Adam ^b   Hendriks, Wiljan J A J ^c   Rolink, Antonius G ^a   Kisielow, Pawel ^a,d  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b WROCLAW MEDICAL UNIVERSITY   (Poland)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

Author keywords

Hemopoietic system; LAR; Phosphatase; T cell; Thymocyte

Indexed keywords

CD19 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; HERMES ANTIGEN; HOMEODOMAIN PROTEIN; LEUKOCYTE ANTIGEN; PROTEIN TYROSINE PHOSPHATASE; STEM CELL FACTOR; TRANSCRIPTION FACTOR PAX5; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL ADHESION; CELL LINEAGE; CELL MATURATION; CELL SELECTION; CELL SPECIFICITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REPRESSION; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEMATOPOIETIC CELL; HEMATOPOIETIC SYSTEM; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; T LYMPHOCYTE; THYMOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BONE MARROW CELLS; CELL LINEAGE; CELLS, CULTURED; CLONE CELLS; CLONING, MOLECULAR; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PRECIPITIN TESTS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SEQUENCE DELETION; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0035077088     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200103)31:3<832::AID-IMMU832>3.0.CO;2-D     Document Type: Article

References (31)

1. The next wave: Protein tyrosine phosphatases enter T cell antigen receptor signalling
2. A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen
3. Form, function, and regulation of protein tyrosine phosphatases and their involvement in human diseases
4. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases
5. MPTP1540;, a putative murine homolog of HPTP1540;, is expressed in specialized regions of the brain and in the B cell lineage
6. Cloning and expression of two structurally distinct receptor-linked protein-tyrosine phosphatases generated by RNA processing from a single gene
7. A novel receptor tyrosine phosphatase-sigma that is highly expressed in the nervous system
8. Neural cell adhesion molecule: Structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing
9. Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR
10. Crystal structure of the tandem phosphatase domains of RPTP LAR
11. The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions
12. Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex
13. Phosphorylation and free pool of β-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration
14. The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR
15. Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation
16. Partial loss of cholinergic neurons and hippocampal innervation in mice lacking LAR tyrosine phosphatase activity
17. Impaired mammary gland development and function in mice lacking LAR receptor-like tyrosine phosphatase activity
18. The transmembrane protein-tyrosine phosphatase LAR modulates signaling by multiple receptor tyrosine kinases
19. Overexpression of the transmembrane tyrosine phosphatase LAR activates the caspase pathway and induces apoptosis
20. Transmembrane tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas
21. Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTP1540; and RPTP5; Sta in the mouse
22. The LAR/PTP1540;/PTP subfamily of transmembrane protein-tyrosine phosphatases: Multiple human LAR, PTP1540;, and PTP isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1
23. Identification of a T cell lineage-specific RNA/DNA helicase and its cell surface expression during intrathymic education of αβ and r; γδ T cells
24. Correction to: Identification of a T cell lineage-specific RNA/DNA helicase and its cell surface expression during intrathymic education of αβ and γδ T cells
25. A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors
26. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
27. Long-term in vivo reconstitution of T cell development by PAX5-deficient B cell progenitors
28. Long-term proliferating early pre-B cell lines and clones with the potential to develop to surface-Ig positive, mitogen-reactive B cells in vitro and in vivo
29. Role of thymic selection in the development of thymic lymphomas in TCR transgenic mice
30. Essential functions of PAX5 (BSAP) in pro-B cell development: Difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus
31. Expression of the receptor-linked protein tyrosine phosphatase LAR: Proteolytic cleavage and shedding of the CAM-like extracellular region