Increased vitamin D receptor level enhances 1,25-dihydroxyvitamin D3-mediated gene expression and calcium transport in Caco-2 cells

Journal of Bone and Mineral Research

Volumn 16, Issue 4, 2001, Pages 615-624

  Shao, A ^a   Wood, R J ^a   Fleet, J C ^b  

^a TUFTS UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

1,25 dihydroxyvitamin D3; 24 hydroxylase; Calbindin D9k; Calcium transport; Enterocyte; Vitamin D receptor

Indexed keywords

CADMIUM; CALBINDIN; CALCIFEDIOL; CALCITRIOL; CALCIUM ION; COMPLEMENTARY DNA; MESSENGER RNA; METALLOTHIONEIN; VITAMIN D RECEPTOR;

ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE CELL; METAL BINDING; MOLECULAR CLONING; VITAMIN D METABOLISM;

CACO-2 CELLS; CADMIUM; CALCITRIOL; CALCIUM; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; DNA, COMPLEMENTARY; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENES, SYNTHETIC; HUMANS; ION TRANSPORT; METALLOTHIONEIN; PROMOTER REGIONS (GENETICS); RECEPTORS, CALCITRIOL; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; STIMULATION, CHEMICAL; TRANSFECTION; TRANSGENES; ZINC;

EID: 0035076409     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.4.615     Document Type: Article

References (58)

1. Current understanding of the molecular actions of vitamin D
2. Intestinal calcium absorption: A vitamin D-hormone-mediated adaptive response
3. Calcium and osteoporosis
4. Nutrition, osteoporosis, and aging
5. Genetics, calcium intake and osteoporosis
6. 3 is impaired in elderly compared to young women
7. 2 vitamin D
8. Effect of age on calcium and phosphate absorption. Role of 1,25-dihydroxyvitamin D
9. The influence of age on the intestinal absorption of 47-Ca absorption in postmenopausal osteoporosis
10. Increased intestinal vitamin D receptor in genetic hypercalciuric rats
11. Estrogen increases 1,25-dihydroxyvitamin D receptors expression and bioresponse in the rat duodenal mucosa
12. In vivo effect of 17 beta-estradiol on intestinal calcium absorption in rats
13. Advancing age results in reduction of intestinal and bone 1,25-dihydroxyvitamin D receptor
14. 3 receptors in Wistar rats
15. Expression of calbindin-D decreases with age in intestine and kidney
16. 3 receptor and vitamin D-dependent calcium binding protein in aged Wistar rats
17. 3 and intestinal vitamin D receptor concentrations in normal women
18. Association between intestinal vitamin D receptor, calcium absorption, and serum 1,25 dihydroxyvitamin D in normal young and elderly women
19. Prediction of bone density from vitamin D receptor alleles
20. A vitamin D receptor gene polymorphism in the translation initiation codon: Effect on protein activity and relation to bone mineral density in Japanese women
21. Vitamin D receptor (VDR) and parathyroid hormone messenger ribonucleic acid levels correspond to polymorphic VDR alleles in human parathyroid tumors
22. 3 receptor levels and augments bioresponses in rat osteoblast-like cells
23. Evidence that estrogens modulate activity and increase the number of 1,25-dihydroxyvitamin D receptors in osteoblast-like cells (ROS 17/2.8)
24. 3 in human osteosarcoma-derived osteoblast-like cells
25. 3 in cultured mouse osteoblast-like cells - Modulation by changes in receptor level
26. 3-mediated regulation of transcellular calcium transport in caco-2 cells
27. Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity
28. Cloning and expression of full-length cDNA encoding human vitamin D receptor
29. Human metallothionein genes - Primary structure of the metallothionein-II gene and a related processed gene
30. Key role of the Cd×2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation
31. Distribution of vitamin D-dependent calcium-binding protein messenger ribonucleic acid in rat placenta and duodenum
32. Cytotoxic effect of cis-parinaric acid in cultured malignant cells
33. 3 in Caco-2 cells
34. 3 analogs with minimal in vivo calcemic activity can stimulate significant transepithelial calcium transport and mRNA expression in vitro
35. Triiodothyronine stimulates the expression of sucrase-isomaltase in Caco-2 cells cultured in serum-free medium
36. Vitamin D-regulated calcium transport in Caco-2 cells: Unique in vitro model
37. Non-saturable Ca transport in the rat intestine is via the paracellular pathway
38. 3 analog KH1060
39. 3. A new characteristic of genetic hypercalciuric stone-forming rats
40. 3 in bone from genetic hypercalciuric rats
41. Effect of age on intestinal calcium absorption and adaptation to dietary calcium
42. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: Formal histomorphometric and biomechanical analyses
43. 3 24-hydroxylase cDNA
44. 3 are differently modified by 9-cis-retinoic acid
45. 3 receptors by parathyroid hormone in osteoblastic cells: Role of second messenger pathways
46. 3 in homotypic macrophage adhesion
47. Stable expression of the nuclear vitamin D receptor in the human prostatic carcinoma cell line JCA-1: Evidence that the antiproliferative effects of 1,25-dihydroxyvitamin D3 are mediated exclusively through the genomic signaling pathway
48. Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture
49. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
50. Characterization of the vitamin D receptor from the Caco-2 human colon carcinoma cell line: Effect of cellular differentiation
51. Calcium transport across epithelia
52. 3 decrease with age
53. Increasing the complexity of coactivation in nuclear receptor signaling
54. Nongenomic actions of the steroid hormone 1 alpha,25-dihydroxyvitamin D3
55. Phosphorylation of the human vitamin D receptor by protein kinase C. Biochemical and functional evaluation of the serine 51 recognition site
56. 3) reverses age-dependent alterations of intestinal calcium uptake in rat enterocytes
57. Molecular cloning of the full-length cDNA encoding the human calbindin-D9k
58. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family