Allelic losses as prognostic markers for breast cancers

International Journal of Clinical Oncology

Volumn 6, Issue 1, 2001, Pages 6-12

  Hirano, A ^a   Utada, Y ^a   Haga, S ^b   Kajiwara, T ^b   Sakamoto, G ^c   Kasumi, F ^c   Nakamura, Y ^d   Emi, M ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c CANCER INSTITUTE   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Breast cancer; Loss of heterozygosity; Postoperative survival; Prognostic marker; Tumor suppressor gene

Indexed keywords

DNA;

ADULT; AGED; ALLELE; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER MORTALITY; CANCER SURVIVAL; CHROMOSOMAL LOCALIZATION; CHROMOSOME 13Q; CHROMOSOME 17P; CHROMOSOME 17Q; CHROMOSOME 1P; CHROMOSOME 3P; CHROMOSOME 8P; CONTROLLED STUDY; FEMALE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; REVIEW; TUMOR SUPPRESSOR GENE;

EID: 0035076366     PISSN: 13419625     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00012082     Document Type: Review

References (58)

1. Staging and prognostic factors
2. Prognostic factors and treatment decision in axillary node-negative breast cancers
3. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
4. Alterations to either c-erbB2 or c-myc proto-oncogenes in breast carcinoma correlate with poor short-term prognosis
5. HER-2/new amplification predicts poor survival in node-positive breast cancer
6. Prevalence of amplification of the oncogenes c-myc, HER2/neu, and int-2 in 1000 human breast tumours: Correlation with steroid receptors
7. p53 gene mRNA expression and chromosome 17p allele loss in breast cancer
8. Loss of heterozygosity and p53 gene mutations in breast cancer
9. Decreased levels of the cell-cycle inhibitor p27-Kip1 protein: Prognostic implications in primary breast cancer
10. Expression of cell-cycle regulators p27-kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
11. Mutations in human breast cancer: An overview
12. Anti-oncogenes and human cancer
13. Allelic loss at 1p34, 13q12, 17p13.3, and 17q21.1 correlates with poor postoperative prognosis in breast cancer
14. Allelic loss at the 8p22 region as a prognostic factor in large and estrogen receptor negative breast carcinomas
15. Allelic loss at 1p34-36 predicts poor prognosis in node-negative breast cancer
16. Loss of heterozygosity at 3p24-p25 as a prognostic factor in breast cancer
17. Localization of breast cancer tumor-suppressor gene to a 3-cM interval within chromosomal region 16q22
18. A comprehensive genetic map of the human genome based on 5264 microsatellites
19. Allelotype of breast cancer: Cumulative allele losses promote tumor progression in primary breast cancer
20. Genetic studies of 457 breast cancers. Clinicopathologic parameters compared with genetic alterations
21. Association of genetic alterations on chromosome 17 and loss of hormone receptors in breast cancer
22. Two distinct commonly deleted regions on chromosome 13q suggest involvement of BRCA2 and retinoblastoma genes in sporadic breast carcinomas
23. Detailed deletion mapping of chromosome arm 3p in breast cancers: A 2-cM region on 3p14.3-21.1 and a 5-cM region on 3p24.3-25.1 commonly deleted in tumors
24. Mapping of breast cancer tumor suppressor gene locus to a 4-cM interval on chromosome 18q21
25. Allelic loss on chromosome 1p is associated with progression and lymph node metastasis of primary breast carcinoma
26. Mapping of a new target region of allelic loss to a 2-cM interval at 22q13.1 in primary breast cancer
27. Frequent allelic loss at the TOC locus on 17q25.1 in primary breast cancers
28. Localization of a tumor suppressor gene associated with the progression of human breast carcinoma within a 1-cM interval of 8p22-p23.1
29. Mapping of target regions of allelic loss in primary breast cancers to 1-cM intervals on genomic contigs at 6q21 and 6q25.3
30. Loss of heterozygosity at chromosome 1p in different solid human tumours: Association with survival
31. Deletion mapping defines different regions in 1p34.2-pter that may harbor genetic information related to human colorectal cancer
32. Frequent genetic alterations at the distal region of chromosome 1p in human hepatocellular carcinomas
33. Infrequent loss of chromosomal heterozygosity in human stomach cancer
34. Significance of chromosome 1p loss of heterozygosity in neuroblastoma
35. Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1p-arm deletions
36. Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression
37. Deletion mapping of chromosome 1p and 22q in pheochromocytoma
38. p73 is a human p53-related protein that can induce apoptosis
39. High levels of allele loss at the FHIT and ATM genes in non-comedo ductal carcinoma in situ and tubular invasive breast cancers
40. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t (3:8) breakpoint, is abnormal in digestive tract cancers
41. The FHIT gene at 3p14.2 is abnormal in lung cancer
42. The FHIT gene at 3p14.2 is abnormal in breast carcinomas
43. Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer
44. Allelic loss at chromosome band 8p21.3-p22 is associated with progression of hepatocellular carcinoma
45. Deletion mapping of the short arms of chromosome 8 in non-small cell lung carcinoma
46. Localization of a tumor suppressor gene associated with progression of human prostate cancer within a 1.2Mb region of 8p22-p21.3
47. Evidence for the presence of two tumor suppressor genes on chromosome 8p for colorectal carcinoma
48. Frequent allelic losses at 11q24.1-q25 in young women with breast cancer: Association with poor survival
49. Loss of heterozygosity at chromosome 11q in lung adenocarcinoma: Identification of three independent regions
50. Identification of a region of frequent loss of heterozygosity at 11q24 in colorectal cancer
51. Refinement of two chromosome 11q regions of loss of heterozygosity in ovarian cancer
52. Mapping loss of heterozygosity at chromosome 13q: Loss at 13q12-q13 is associated with breast tumour progression and poor prognosis
53. Patterns of loss of heterozygosity at loci from chromosome arm 13q suggest a possible involvement of BRCA2 in sporadic breast tumors
54. Deletion within the D17S34 locus in a primitive neuroectodermal tumor
55. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor
56. Prognostic significance of p53 gene mutations in node-negative breast cancer
57. Multiplex mutation screening of the BRCA1 gene in 1000 Japanese breast cancers
58. Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: Correlation with disease characteristics