Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: Identification of domains important for bacterial adherence

Cellular Microbiology

Volumn 3, Issue 3, 2001, Pages 133-143

  Källström, Helena ^a,b   Gill, Darcy Blackmer ^c   Albiger, Barbara ^a,b   Liszewski, M Kathryn ^c   Atkinson, John P ^c   Jonsson, Ann Beth ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; COMPLEMENT CONTROL PROTEIN REPEAT 3; ISOPROTEIN; MEMBRANE COFACTOR PROTEIN; PROLINE; REGULATOR PROTEIN; SERINE; THREONINE; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIUM ADHERENCE; BACTERIUM PILUS; BINDING SITE; CELL INTERACTION; CELL LINE; CELL STRAIN; CHO CELL; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOPLASM; EPITHELIUM CELL; GENE CONSTRUCT; GENE DELETION; GENETIC TRANSFECTION; HOST CELL; HUMAN; HUMAN CELL; MOLECULE; NEISSERIA GONORRHOEAE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; REGULATORY MECHANISM;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD46; BACTERIAL ADHESION; BLOTTING, WESTERN; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; CRICETINAE; EPITHELIAL CELLS; FIMBRIAE, BACTERIAL; GONORRHEA; HUMANS; MEMBRANE GLYCOPROTEINS; NEISSERIA GONORRHOEAE; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

ANIMALIA; BACTERIA (MICROORGANISMS); NEISSERIA GONORRHOEAE;

EID: 0035076258     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1462-5822.2001.00095.x     Document Type: Article

References (44)

1. Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity
2. Crystal structure of two CD46 domains reveals an extended measles virus-binding surface
3. CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins
4. Adherence of pilus- Opa+ gonococci to epithelial cells in vitro involves heparan sulphate
5. Mapping of epitopes, glycosylation sites, and complement regulatory domains in human decay accelerating factor
6. The human CD46 molecule is a receptor for measles virus (Edmonston Strain)
7. CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes
8. Use of site-specific mutagenesis and monoclonal antibodies to map regions of CD46 that interact with measles virus H protein
9. Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD46
10. Polymorphic expression of CD46 protein isoforms due to tissue-specific RNA splicing
11. Phase variation of gonococcal pili by frame shift mutation in pilC, a novel gene for pilus assembly
12. Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria
13. Cell signaling by the type IV pili of pathogenic Neisseria
14. Mechanism of suppression of cell-mediated immunity by measles virus
15. Neisseria gonorrhoeae. II. Colonial variation and pathogenicity during 35 month in vitro
16. Membrane cofactor protein (MCP; CD46): Isoforms differ in protection against the classical pathway of complement
17. Membrane cofactor protein (MCP or CD46): Newest member of the regulators of complement activation gene cluster
18. Membrane cofactor protein (CD46) of complement: Processing differences related to alternatively-spliced cytoplasmic domains
19. Control of the complement system
20. Membrane cofactor protein: Importance of N-linked and O-glycosylation for complement regulatory function
21. Dissecting sites important for complement regulatory activity in membrane cofactor protein (MCP; CD46)
22. Phospholipid anchored and transmembrane version of either decay accelerating factor or membrane co-factor protein show equal efficiency in protection from complement mediated cell damage
23. Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46)
24. Measles virus recognized its receptor, CD46, via two distinct binding domains within SCR1-2
25. A 3D model for the measles virus receptor CD46 based on homology modelling. Monte Carlo simulations, and hemagglutination binding studies
26. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus
27. Interactions of pathogenic Neisseria with host cells. Is it possible to assemble the puzzle?
28. Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus
29. Structural and functional studies of the measles virus hemagglutinin: Identification of a novel site required for CD46 interaction
30. Membrane cofactor protein of the complement system: Alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotypes
31. The meningococcal PilT protein is required for induction of intimate attachment to epithelial cells following pilus-mediated adhesion
32. Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation
33. Binding of syndecan-like cell surface proteoglycan receptors is required for Neisseria gonorrhoeae entry into human mucosal cells
34. Neisseria PilC protein identified as type-4 pilus tip-located adhesin
35. CD46 is a cellular receptor for human herpes virus 6
36. Role of decay-accelerating factor in internalization of Dr-fimbriated Escherichia coli
37. CD46 (membrane cofactor protein of complement, measles virus receptor): Structural and functional divergence among species
38. Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1
39. - changes in Neisseria gonorrhoeae
40. The N-domain of the human CD66a adhesion molecule is a target for Opa proteins of Neisseria meningitidis and Neisseria gonorrhoeae
41. Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae
42. Type IV pili and cell motility
43. Membrane cofactor protein: Isoform specific tyrosine phosphorylation
44. The cytoplasmic domains of complement regulatory protein CD46 interact with multiple kinases in macrophages