The cytoplasmic domains of complement regulatory protein CD46 interact with multiple kinases in macrophages

Journal of Leukocyte Biology

Volumn 62, Issue 6, 1997, Pages 892-900

  Wong, Timothy C ^a   Yant, Stephen ^a   Harder, Brandon J ^a   Korte Sarfaty, Jennifer ^a   Hirano, Akiko ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Fusion proteins; Measles virus; Monocytes

Indexed keywords

GLUTATHIONE TRANSFERASE; MEMBRANE COFACTOR PROTEIN; PHOSPHOTRANSFERASE;

ANIMAL CELL; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOMODULATION; MACROPHAGE; MEASLES VIRUS; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; VIRUS CELL INTERACTION;

EID: 0031469642     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.62.6.892     Document Type: Article

References (46)

1. Liszewski, K. M., Post, T. W., Atkinson, J. P. (1991) Membrane cofactor protein (MCH or CD46): newest member of the regulators of complement activation gene cluster. Annu. Rev. Immunol. 9, 431-455.
2. Seya, T. (1995) Human regulator of complement activation (RCA) gene family proteins and their relationship to microbial infection. Microbiol. Immunol. 39, 295-305.
3. Dorig, R. E., Marcil, A., Chopra, A., Richardson, C. D. (1993) The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75, 295-305.
4. Naniche, D., Varior-Krishnan, G., Cervoni, F., Wild, T. F., Rossi, B., Rabourdin-Combe, C., Gerlier, D. (1993a) Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J. Virol. 67, 6025-6032.
5. Griffin, D. E., Ward, B. J., Esolen, L. M. (1994) Pathogenesis of measles virus infection: a hypothesis for altered immune responses. J. Infect. Dis. 170, S24-S31.
6. Naniche, D, Wild, T. F., Rabourdin-Combe, C., Gerlier, D. (1993b) Measles virus haemagglutinin induces down-regulation of gp/57/67, a molecule involved in virus binding. J. Gen. Virol. 74, 1073-1079.
7. Hirano, A., Yant, S., Iwata, K., Korte-Sarfaty, J., Seya, T., Nagasawa, S., Wong, T. C. (1996) Human cell receptor CD46 is down regulated through recognition of a membrane-proximal region of the cytoplasmic domain in persistent measles virus infection. J. Virol. 70, 6929-6936.
8. Schnorr, J. J., Dunster, L. M., Nanan, R., Schneider-Shaulies, J., ter Meulen, V. (1995) Measles virus-induced down regulation of CD46 is associated with enhanced sensitivity to complement-mediated lysis of infected cells. Eur. J. Immunol. 25, 976-984.
9. Schlender, J., Schnorr, J.-J., Spielhoffer, P., Cathomen, T., Cattaneo, R., Billeter, M. A., ter Meulen, V., Schneider-Schaulies, S. (1996) Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in vitro. Proc. Natl. Acad Sci. USA 93, 13194-13199.
10. Schnorr, J.-J., Xanthakos, S., Keikavoussi, P., Kampgen, E., ter Meulen, V., Schneider-Schaulies, S. (1997) Induction of maturation of human blood cell precursors by measles virus is associated with immunosuppression. Proc. Natl. Acad. Sci. USA 94, 5326-5331.
11. Karp, C. L., Wysocka, M., Wahl, L. M., Ahearn, J. M., Cuomo, P. J., Sherry, B., Trinchieri, G., Griffin, D. E. (1996) Mechansim of suppression of cell-mediated immunity by measles virus. Science 273, 228-231.
12. Trinchieri, G. (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridges innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13, 251-276.
13. Lublin, D. M., Liszewski, M. K., Post, T. W., Arce, M. A., Le Beau, M. M., Rebentisch, M. B., Lemons, R. S., Seya, T., Atkinson, J. P. (1988) Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). J. Exp. Med. 168, 181-194.
14. Post, T. W., Liszewski, M. K., Adams, E. M., Tredja, I., Miller, E. A., Atkinson, J. P. (1991) Membrane cofactor protein of the complement system: alternative splicing of the serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype. J. Exp. Med. 174, 93-102.
15. Purcell, D. F. J., Russell, S. M., Deacon, N. J., Brown, M. A., Hooker, D. J., MeKenzie, I. F. C. (1991) Alternatively spliced RNAs encode several isoforms of CD6 (MCP), a regulator of complement activation. Immunogenetics 33, 335-344.
16. Adams, E. M., Brown, M. C., Nunge, M., Krych, M., Atkinson, J. P. (1991) Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity. J. Immunol. 147, 3005-3011.
17. Manchester, M., Valsamakis, A., Kaufman, R., Liszewski, M. K., Alvarez, J., Atkinson, J. P., Lublin, D. M., Oldstone, M. B. A. (1995) Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46). Proc. Natl. Acad. Sci. USA 92, 2303-2307.
18. Iwata, K., Seya, T., Yanagi, Y., Pesando, J. M., Johnson, P. M., Okabe, M., Ueda, S., Ariga, H., Nagasawa, S. (1995) Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD46. J. Biol. Chem. 270, 1-5.
19. Lublin, D. M., Coyne, K. E. (1991) Phospholipid-anchored and transmembrane versions of either decay-accelerating factor or membrane cofactor protein show equal efficiency in protection from complement-mediated cell damage. J. Exp. Med. 174, 35.
20. Varior-Krishnan, G., Trescol-Biemont, M.-C., Naniche, D., Rabourdin-Combe, C., Gerlier, D. (1994) Glycosyl-phosphatidylinositol-anchored and transmembrane forms of CD46 display similar measles virus receptor properties: virus binding, fusion, and replication: down-regulation by hemagglutinin; and virus uptake and endocytosis for antigen presentation by major histocompatibility complex class II molecules. J. Virol. 68, 7891-7899.
21. Maisner, A., Liszewski, M. K., Atkinson, J. P., Schwartz-Albiez, R., Herrler, G. (1996) Two different cytoplasmic tails direct isoforms of the membrane cofactor protein (CD46) to the basolateral surface of Madin-Darby canine kidney cells. J. Biol. Chem. 271, 18853-18858.
22. Yant, S., Hirano, A., Wong, T. C. (1997) Identification of a cytoplasmic Tyr-X-X-Leu motif essential for down regulation of the human cell receptor CD46 in persistent measles virus infection. J. Virol. 71, 766-770.
23. Peters, C., Braun, M., Weber, B., Wendland, M., Schmidt, B., Pohlmann, R., Waheed, A., von Figura, K. (1990) Targeting of a lysosomal membrane protein: a tyrosine containing endocytosis signal in the cytoplasmic tail of lysosomal acid phosphatase is necessary and sufficient for targeting to lysosomes. EMBO J. 9, 3497-3506.
24. Williams, M. A., Fakuda, M. (1990) Accumulation of membrane glycoproteins in lysosomes requires a tyrosine residue at a particular position in the cytoplasmic tail. J. Cell Biol. 111, 955-966.
25. Honing, S., Griffith, J., Geuze, H. J., Hunziker, W. (1996) The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles. EMBO J. 15, 5230-5239.
26. Isakov, N. (1997) Immunoreceptor tyrosine-based activation motif (ITAM), a unique module linking antigen and Fc receptors to their signaling cascades. J. Leukoc. Biol. 61, 6-16.
27. Samelson, L. E., Klausner, R. D. (1992) Tyrosine kinases and tyrosine-based activation motifs. J. Biol. Chem. 267, 24913-24916.
28. Sefton, B. M., Taddie, J. A. (1994) Role of tyrosine kinases in lymphocyte activation. Curr. Op. Immunol. 6, 372-379.
29. Indik, Z. K., Park, J. G., Hunter, S., Schreiber, A. D. (1995) Structure/ function relationships of Fc gamma receptors in phagocytosis. Semin. Immunol. 7, 45-54.
30. Park, J. G., Schreiber, A. D. (1995) Determinants of the phagocytic signal mediated by the type IIIA Fc gamma receptor. FcγRIIIA: sequence requirements and interaction with protein-tyrosine kinases. Proc. Natl. Acad. Sci. USA 92, 7381-7385.
31. Shaw, A. S., Gauen, L. K. T., Zhu, Y. (1995) Interactions of TCR tyrosine based activation motifs with tyrosine kinases. Semin. Immunol. 7, 13-20.
32. Flaswinkel, H., Barner, M., Reth, M. (1995) The tyrosine activation motif as a target of protein tyrosine kinases and SH2 domains. Semin. Immunol. 7, 21-27.
33. Russell, S. M., Loveland, B. E., Johnstone, R. W., Thorley, B. R., McKenzie, I. F. (1992) Functional characterization of alternatively spliced CD46 cytoplasmic tails. Transplant. Proc. 24, 2329-2330.
34. Weinstein, S. L., Gold, M. R., DeFranco, A. L. (1991) Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages. Proc. Natl. Acad. Sci. USA 88, 4148-4152.
35. Sherman, M. Y., Goldberg, A. L. (1992) Involvement of the chaperonin dnak in the rapid degradation of a mutant protein in Escherichia coli. EMBO J. 11, 71-77.
36. Ferrell, J. E., Jr., Martin, G. S. (1991) Assessing activities of blotted protein kinases. Meth. Enzymol. 200, 430-435.
37. Feller, S. M., Ren, R., Hanafusa, H., Baltimore, D. (1994) SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl. Trends Biochem. Sci. 19, 453-458.
38. Pawson, T. (1994) SH2 and SH3 domains in signal transduction. Adv. Cancer Res. 64, 87-110.
39. Seya, T., Kurita, M., Iwata, K., Yanagi, Y., Tanaka, K., Shida, K., Hatanaka, M., Matsumoto, M., Jun, S., Hirano, A., Ueda, S., Nagasawa, S. (1997) The CD46 transmembrane domain is required for efficient formation of measles virus-mediated syncytium. Biochemistry 322, 135-144.
40. Liszewski, M. K., Tedja, I., Atkinson, J. P. (1994) Membrane cofactor protein (CD46) of complement. Processing differences related to alternatively spliced cytoplasmic domains. J. Biol. Chem. 269, 10776-10779.
41. Buchholz, C. J., Gerlier, D., Hu, A., Cathomen, T., Liszewski, M. K., Alkinson, I. P., Cattaneo, R. (1996) Selective expression of a subset of measles virus receptor-competent CD46 isoforms in human brain. Virology 217, 349-355.
42. Sweet, M. J., Hume, D. A. (1996) Endotoxin signal transduction in macrophages. J. Leukoc. Biol. 60, 8-26.
43. Songyang, Z., Shoelson, S. E., Chaudhuri, M., Gish, G., Pawson, T., Haser, W. G., King, F., Roberts, T., Ratnofsky, S., Lechleider, R. J., Neel, B. G., Birge, R. B., Fajardo, J. E., Chou, M. M., Hanafusa, H., Schaffhausen, B., Cantley, L. C. (1993) SH2 domains recognize specific phosphopeptide sequences. Cell 72, 767-778.
44. Alonso, G., Koegl, M., Mazurenko, N., Courtneidge, S. A. (1995) Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors. J. Biol. Chem. 270, 9840-9848.
45. Schneider-Schaulies, J., Dunster, L. M., Schwartz-Albiez, R., Krohne, G., ter Meulen, V. (1995) Physical association of moesin and CD46 as a receptor complex for measles virus. J. Virol. 69, 2248-2256.
46. Carpen, O., Pallai, P., Staunton, D. E., Springer, T. A. (1992) Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and α-actinin. J. Cell Biol. 118, 1223-1234.