Inflammatory macrophage nuclear factor-κB and proteasome activity are inhibited following exposure to inhaled isobutyl nitrite

Journal of Leukocyte Biology

Volumn 69, Issue 4, 2001, Pages 639-644

  Ponnappan, Usha ^a   Soderberg, Lee S F ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

AIDS; Immunosuppression; Inhalant; Kaposi's sarcoma; Signal transduction

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOBUTYL NITRITE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEASOME;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KAPOSI SARCOMA; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PERITONEUM EXUDATE; PRIORITY JOURNAL;

ADMINISTRATION, INHALATION; ANIMALS; BUTANES; CYSTEINE ENDOPEPTIDASES; CYTOTOXICITY, IMMUNOLOGIC; DEPRESSION, CHEMICAL; DISEASE SUSCEPTIBILITY; FEMALE; HIV INFECTIONS; IMMUNITY, CELLULAR; IMMUNOLOGIC DEFICIENCY SYNDROMES; INFLAMMATION; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MULTIENZYME COMPLEXES; NF-KAPPA B; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROTEASOME ENDOPEPTIDASE COMPLEX; RISK FACTORS; SARCOMA, KAPOSI; SUBSTANCE-RELATED DISORDERS; TUMOR CELLS, CULTURED;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0035073227     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. National case-control study of Kaposi's sarcoma and Pneumocystis carnii pneumonia in homosexual men: Part 1. Epidemiologic results
2. Correlates of condom failure in a sexually active cohort of men who have sex with men
3. Risk factors for human immunodeficiency virus (HIV) infections in homosexual men
4. The relation between nitrite inhalants, unprotected receptive anal intercourse, and the risk of human immunodeficiency virus infection
5. Nitrite inhalants: History, epidemiology, and possible links to AIDS
6. Measuring inhalant nitrite exposure in gay men: Implications for elucidating the etiology of AIDS-related Kaposi's sarcoma
7. Leukopenia and altered hematopoietic activity in mice exposed to the abused inhalant, isobutyl nitrite
8. Inhaled isobutyl nitrite compromises T-dependent, but not T-independent antibody induction
9. T cell functions are impaired by inhaled isobutyl nitrite through a T-independent mechanism
10. Inhalation exposure to isobutyl nitrite inhibits macrophage tumoricidal activity and modulates inducible nitric oxide
11. Increased tumor growth in mice exposed to inhaled isobutyl nitrite
12. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
13. Induction and regulation of NF-kB during aging: Role of protein kinases
14. Low environmental pH is responsible for the induction of nitric-oxide synthase in macrophages. Evidence for involvement of nuclear factor-kappaB activation
15. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages
16. Evidence for lowered induction of nuclear factor kappa B in activated human T lymphocytes during aging
17. The ubiquitin-proteasome pathway is required for processing the NFkB1 precursor protein and the activation of NFkB
18. Skeletal muscle proteasome can degrade proteins in an ATP-dependent process that does not require ubiquitin
19. Elevated TNF-α and inducible nitric oxide production by alveolar macrophages after exposure to a nitrite inhalant
20. Acute inhalation exposure to isobutyl nitrite causes nonspecific blood cell destruction
21. Inhibition of IkappaB-α and IkappaB-β proteolysis by calpain inhibitor I blocks nitric oxide synthesis
22. Nitric oxide inhibits HIV Tat-induced NF-kappaB activation
23. Nitrite inhalants spontaneously liberate nitric oxide, which is not responsible for the immunotoxicity in C57BL/6 mice
24. Acute exposure to the abused inhalant, isobutyl nitrite, reduced T cell responsiveness and spleen cellularity
25. Inhibition of NF-kappaB and HIV-1 long terminal repeat transcriptional activation by inducible nitric oxide synthase 2 activity