The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo

Development

Volumn 128, Issue 6, 2001, Pages 849-858

  Bauer, H ^a   Lele, Z ^a   Rauch, G J ^a   Geisler, R ^a   Hammerschmidt, M ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

Alk8; Bmp2b; Bmp7; Dorsoventral patterning; Lost a fin; Morpholino antisense oligonucleotides; Smad5; Zebrafish

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE; ANTISENSE OLIGONUCLEOTIDE; ARGININE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; CYSTEINE; GENE PRODUCT; MEMBRANE RECEPTOR; MESSENGER RNA; OSTEOGENIC PROTEIN 1; PROTEIN SERINE THREONINE KINASE RECEPTOR; SMAD PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ECTODERM; EMBRYO; EMBRYO PATTERN FORMATION; GENE MUTATION; INJECTION; MESODERM; MOTHER; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ZEBRA FISH; ZYGOTE;

ACTIVIN RECEPTORS; ANIMALS; BODY PATTERNING; BONE MORPHOGENETIC PROTEINS; CLONING, MOLECULAR; CROSSES, GENETIC; EMBRYO, NONMAMMALIAN; GENOTYPE; LINKAGE (GENETICS); MUTAGENESIS; PHENOTYPE; PHYLOGENY; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; ZEBRAFISH; ZEBRAFISH PROTEINS;

ANIMALIA; DANIO RERIO; VERTEBRATA;

EID: 0035072578     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. The ALK-2 and ALK-4 activin receptors transduce distinct mesoderm-inducing signals during early Xenopus development but do not cooperate to establish thresholds
2. Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors
3. A transforming growth factor β type I receptor that signals to activate gene expression
4. Follistatin and Noggin are excluded from the zebrafish organizer
5. Cleavage of the BMP-4 antagonist Chordin by zebrafish Tolloid
6. Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila
7. A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, mothers against dpp and the BMP-7 homologue, 60A
8. Determinants of specificity in TGF-β signal transduction
9. Smad1 recognition and activation by the ALK1 group of transforming growth factor-β family receptors
10. The role of tolloid/minifin in dorsoventral pattern formation of the zebrafish embryo
11. Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover
12. Bone morphogenetic protein 4: A ventralizing factor in early Xenopus development
13. Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo
14. Determination of type I receptor specificity by the type II receptors for TGF-beta or activin
15. A radiation hybrid map of the zebrafish genome
16. Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo
17. Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila
18. dino and mercedes, two genes regulating dorsal development in the zebrafish embryo
19. Genetic analysis of dorsoventral pattern formation in the zebrafish: Requirement of a BMP-like ventralizing activity and its dorsal repressor
20. Strategies to perturb zebrafish development
21. Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction
22. β-catenin signaling activity dissected in early Xenopus embryos: A novel antisense approach
23. The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo
24. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
25. DVR-4 (bone morphogenetic protein-4) as a posterior ventralizing factor in Xenopus mesoderm induction
26. TGFβ/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing
27. The molecular nature of swirl: BMP2 function is essential during early dorsoventral patterning
28. A microsatellite genetic linkage map for zebrafish (Danio rerio)
29. The TGF-β mediator Smad1 is directly phosphorylated and functionally activated by the BMP receptor kinase
30. Human type II receptor for bone morphogenic proteins (BMPs): Extension of the two-kinase receptor model to the BMPs
31. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
32. A truncated bone morphogenetic protein receptor alters the fate of ventral mesoderm to dorsal mesoderm: Roles of animal pole tissue in the development of the ventral mesoderm
33. TGF-β signal transduction
34. Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation
35. Genes establishing dorsoventral pattern formation in the zebrafish embryo: The ventral specifying genes
36. Effective targeted gene knockdown in zebrafish
37. Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic
38. Spatially restricted activation of the SAX receptor by SCW modulates DPP/TKV signaling in Drosophila dorsalventral patterning
39. Interpretation of a BMP activity gradient in Drosophila embryos depends on synergistic signaling by two type I receptors, SAX and TKV
40. Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes
41. Conservation of BMP signaling in zebrafish mesoderm patterning
42. In vivo analysis using variants of zebrafish BMPR-1A: Range of action and involvement of BMP in ectoderm patterning
43. Restricted expression of the receptor serine/threonine kinase BMPR-IB in zebrafish
44. cDNA sequence of zebrafish (Brachydanio rerio) translation elongation factor-1 alpha: Molecular phylogeny of eukaryotes based on elongation factor-1 alpha protein sequences
45. Cloning of the zebrafish krox-20 (krx-20) and its expression during hindbrain development
46. A possible molecular mechanism for Spemann organizer function: Inhibition of ventral signals by direct binding of Chordin to BMP-4
47. Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity
48. A polymorphic zebrafish line for genetic mapping using SSLPs on high-percentage agarose gels
49. Xenopus embryos regulate the nuclear localization of XMyoD
50. Equivalent genetic roles of bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation
51. Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo
52. The zebrafish organizer requires chordino
53. Mutations affecting cell fates and cellular rearrangements during gastrulation in the zebrafish
54. A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo
55. Identification of type I receptors for Osteogenic Protein-1 and Bone Morphogenetic Protein-4
56. GS domain mutations that constitutively activate TβR-1, a downstream signaling component in the TGFβ receptor complex
57. Induction of epidermis and inhibition of neural fate by Bmp-4
58. Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex
59. Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
60. zALK-8, a novel type I serine/threonine kinase receptor, is expressed throughout early zebrafish development