Occupational exposure to volatile anaesthetics: Epidemiology and approaches to reducing the problem

CNS Drugs

Volumn 15, Issue 3, 2001, Pages 197-215

  Byhahn, C ^a   Wilke, H J ^a   Westphal, K ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DESFLURANE; ENFLURANE; HALOTHANE; INHALATION ANESTHETIC AGENT; ISOFLURANE; PROPOFOL; SEVOFLURANE;

AIR CONDITIONING; ANESTHETIC EQUIPMENT; BIRTH DEFECT; BRONCHOSCOPY; COGNITIVE DEFECT; DNA DAMAGE; HEALTH CARE PERSONNEL; HUMAN; INTENSIVE CARE; LAMINAR AIRFLOW; LIVER TOXICITY; LONG TERM EXPOSURE; MAXIMUM ALLOWABLE CONCENTRATION; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; OPERATING ROOM; PRIORITY JOURNAL; REVIEW; SPONTANEOUS ABORTION; TERATOGENICITY; WORKPLACE;

EID: 0035070309     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-200115030-00004     Document Type: Review

References (152)

1. Über die beseitigung der narkosedämpfe aus dem operationssaale
2. Schutz der am operationstisch beschäftigten vor schädigung durch die narkosegase
3. Halothane anesthesia as a possible cause of massive hepatic necrosis
4. Hepatic necrosis associated with halothane anesthesia
5. Liver necrosis after halothane anesthesia: Cause or coincidence?
6. Halothane hepatitis in an anaesthetist
7. Recurrent hepatitis attributable to halothane sensitization in an anesthetist
8. Halothane biotransformation in man: A quantitative study
9. Biodegradation and organ toxicity of new volatile anesthetics
10. Is enflurane hepatotoxic?
11. Nephrotoxicity of sevoflurane versus desflurane anesthesia in volunteers
12. High carboxyhemoglobin concentrations occur in swine during desflurane anesthesia in the presence of partially dried carbon dioxide absorbents
13. Biotransformation of halothane, enflurane, isoflurane, and desflurane to trifluoroacetylated liver proteins: Association between protein acylation and hepatic injury
14. Hepatic dysfunction after isoflurane anesthesia
15. The biotransformation of ethrane in man
16. Resistance of isoflurane to biotransformation in man
17. Metabolism of I-653 and isoflurane in swine
18. Biotransformation of sevoflurane
19. Halothane hepatitis in a laboratory technician
20. Occupational hazard of halothane
21. Hepatic damage after exposure to halothane in medical personnel
22. A nurse with liver injury associated with occupational exposure to halothane in a recovery unit
23. Halothane related liver affection in an anaesthetist
24. Chemical hepatitis associated with occupational exposure to halothane in a research laboratory
25. Antimitochondrial antibodies in jaundice following drug administration
26. Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis
27. Oxidative metabolism of halothane in the production of altered hepatocyte membrane antigens in acute halothane-induced hepatic necrosis
28. A report of hepatic necrosis and death following isoflurane anesthesia
29. Mortality experience among anesthesiologists 1954-1976
30. Studies of the toxicity of I-653, halothane, and isoflurane in enzyme-induced, hypoxic rats
31. Hepatocellular integrity in swine after prolonged desflurane (I-653) and isoflurane anesthesia: Evaluation of plasma alanine aminotransferase activity
32. Desflurane versus isoflurane in patients with chronic hepatic and renal disease
33. Serum glutathione S-transferase concentrations and creatinine clearance after sevoflurane anaesthesia
34. Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers
35. Mutagenicity of the combination of a volatile anaesthetic and nitrous oxide
36. Sister chromatid exchanges in cigarette smokers: Effects of halothane, isoflurane or subarachnoid blockade
37. Mutagenicity of inhaled anesthetics in Drosophila melanogaster
38. Sister chromatid exchanges and structural chromosome aberrations in lymphocytes in operating room personnel
39. Lack of mutagenic effects of halothane in mammals in vivo
40. Sister chromatid exchanges in lymphocytes after anaesthesia with halothane or enflurane
41. Mutagenicity studies with halothane in Drosophila melanogaster
42. Sister chromatid exchanges induced by inhaled anesthetics
43. A study of the mutagenicity of anesthetics and their metabolites
44. Lack of mutagenic effect of halothane or chloroform on cultured cells using the azaguanine test system
45. Mutagenicity of volatile anesthetics: Halothane
46. Sister chromatid exchanges in lymphocyte cultures exposed to halothane and sevoflurane
47. Mutagenicity studies with volatile metabolites of halothane
48. Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane
49. Evaluation of the mutagenic potential of enflurane and isoflurane by sister chromatid exchange
50. Sister chromatid exchanges in lymphocytes of humans anaesthetized with isoflurane
51. Sister chromatid exchange in human lymphocytes exposed to isoflurane and nitrous oxide in vitro
52. Waste anaesthetic gases induce sister chromatid exchanges in lymphocytes of operating room personnel
53. Genetic damage in operating room personnel exposed to isoflurane and nitrous oxide
54. Mutagenicity of experimental inhalational anesthetic agents: Sevoflurane, synthane, dioxychlorane, and dioxyflurane
55. Compound A induces sister chromatid exchanges in Chinese hamster ovary cells
56. The teratogenicity of halothane in the rat
57. The action of halothane in causing abortion
58. Ultrastructural studies on the pathological change in the neonatal kidney following in utero exposure to halothane
59. Lack of teratogenic dangers with halothane
60. Behavioral consequences in rats from chronic exposure to 10 ppm halothane during early development
61. Pathological changes in the nervous system following in utero exposure to halothane
62. Reproductive and teratologic studies with halothane
63. Analysis of fetal development in rats following maternal exposure to subanesthetic concentrations of halothane
64. Behavioral and neurochemical effects of prenatal halothane
65. Review of effects of chronic exposure to low levels of halothane
66. Behavioral effects of exposure to halothane during early development in the rat: Sensitive period during pregnancy
67. Embryotoxicity and fertility study with halothane subanaesthetic concentrations in rats
68. Decreased myelin synthesis in developing rats following repeated pre- and perinatal exposure to subanesthetic amounts of halothane
69. A halothane-related effect on rat brain myelination: A comparison of chronic prenatal or postnatal exposure
70. Maternal and paternal chronic exposure to enflurane and halothane: Fetal and histological changes in the rat
71. Fetotoxicity in rats following chronic exposure to halothane, nitrous oxide, or methoxyflurane
72. Effects of halothane on the development of rat brain: A Golgi study of dendritic growth
73. Effects of halothane on synaptogenesis and learning behaviour in rats
74. Reproductive and teratogenic effects of nitrous oxide, halothane, isoflurane, and enflurane in Sprague-Dawley rats
75. Effect of halothane on brain 2′,3′-cyclic nucleotide 3′-phosphodiesterase during neurodevelopment in the rat
76. Cleft palate induced by halothane anesthesia in C-57 black mice
77. Murine fertility unaffected by traces of halothane
78. Fertility, reproduction and postnatal survival in mice chronically exposed to halothane
79. Fetal morphology in mice exposed to halothane
80. Behavioral effects in mice exposed to nitrous oxide or halothane: Prenatal vs. postnatal exposure
81. Reproductive and teratologic studies with isoflurane
82. Chronic exposure of rats to enflurane 200 ppm: No evidence of toxicity or teratogenicity
83. Toxicity and teratogenicity of inhaled anesthetics in Drosophila melanogaster
84. Reproductive and teratogenic effects of nitrous oxide, isoflurane, and their combination in Sprague-Dawley rats
85. Working conditions in surgery and their effect on the health of anesthesiologists
86. Levels of consciousness in volunteers breathing sub-MAC concentrations of isoflurane
87. Subjective, psychomotor, cognitive, and analgesic effects of subanesthetic concentrations of sevoflurane and nitrous oxide
88. Psychological studies of human performance as affected by traces of enflurane and nitrous oxide
89. Effects of trace anaesthetic gases on behavioural performance of volunteers
90. Neurotoxicity in operating room personnel working with gaseous and nongaseous anesthesia
91. Immunological disturbances in anaesthetic personnel chronically exposed to high occupational concentrations of nitrous oxide and halothane
92. Age-dependent haematological disturbances in anaesthetic personnel exposed to high occupational concentrations of halothane and nitrous oxide
93. Exposure of the workplace and the environment by narcotic gases
94. Sick building syndrome. Medical evaluation of two work forces
95. Neurobehavioral functions in operating theatre personnel exposed to anesthetic gases
96. Neurobehavioral functions in operating theatre personnel: A multicenter study
97. Operating room nurses' psychomotor and driving skills after occupational exposure to halothane and nitrous oxide
98. Trace anesthetic effects on perceptual, cognitive, and motor skills
99. Effect of halothane on motor skills and memory in anaesthetists
100. Occupational disease among operating room personnel: A national study
101. Critique: Occupational disease among operating room personnel
102. Trace concentrations of anesthetic gases: A critical review of their disease potential
103. Health effects associated with exposure to anaesthetic gases in Ontario hospital personnel
104. Work in operating rooms and pregnancy outcome among nurses
105. Occupational exposure to sevoflurane during sedation of adult patients
106. Halothane content in recovery room air
107. On the question of health impairment to anaesthetists due to chronic inhalation of halothane and methoxyflurane
108. The concentrations of halothane in the operating theatre and its dependence on various methods of removal
109. Infrared spectrometry and gas chromatography for determination of halothane in operation rooms
110. Sevoflurane contamination during paediatric bronchoscopy
111. Inhalational induction with sevoflurane in adults - Efficacy, safety, patient preference and occupational exposure
112. Room air contamination with halothane during pediatric bronchoscopy
113. Occupational exposure during mask induction and use of different types of endotracheal tubes
114. Occupational exposure to nitrous oxide and desflurane during ear-nose-throat-surgery
115. Surgeon's occupational exposure to nitrous oxide and sevoflurane during pediatric surgery
116. Pollution with nitrous oxide using laryngeal mask or face mask
117. Isoflurane waste gas exposure during general anaesthesia: The laryngeal mask compared with tracheal intubation
118. Low flow anaesthesia reduces occupational exposure to inhalation anaesthetics
119. Waste gas exposure during desflurane and isoflurane anaesthesia
120. Occupational exposure to waste anesthetic gases during ENT surgery
121. Occupational exposure to the inhalational anesthetic agents nitrous oxide and desflurane during pediatric strabism surgery
122. Occupational exposure to enflurane and nitrous oxide in operating rooms
123. Occupational exposure to sevoflurane and nitrous oxide in operating room personnel
124. Occupational exposure with inhalation anesthetics during cardiac surgery
125. Occupational exposure to sevoflurane, halothane and nitrous oxide during paediatric anaesthesia
126. Distribution of waste anesthetic gases in the operation room air
127. Exposure of pregnant recovery room and surgical intensive-care unit personnel to inhalational anaesthetics
128. Exposure of postoperative nurses to exhaled anesthetic gases
129. Exposure of intensive-care unit personnel to isoflurane in long-term sedation
130. Occupational exposure to anaesthetic gases during paediatric surgery
131. Exposure to sevoflurane and nitrous oxide during four different methods of anesthetic induction
132. Exposure of anesthetists to sevoflurane and nitrous oxide during inhalational anesthetic induction in pediatric anesthesia
133. Environmental monitoring during geseous induction with sevoflurane
134. Control of occupational exposure to nitrous oxide in the dental operatory
135. Toxicity of bone marrow in dentists exposed to nitrous oxide
136. Reduced fertility among women employed as dental assistants exposed to high levels of nitrous oxide
137. Nitrous oxide sedation: Understanding the benefits and risks
138. Nitrous oxide and spontaneous abortion in female dental assistants
139. Isoflurane for prolonged sedation in the intensive care unit; efficacy and safety
140. Occupational exposure and environmental pollution: The role of inhalation anaesthetics with special consideration of sevoflurane
141. The double mask a new local scavenging system for anaesthetic gases and volatile agents
142. Assessment of a new scavenging device for use in paediatric anaesthesia
143. Concentration and elimination of anaesthetic gases in recovery rooms
144. Tropospheric lifetimes of halogenated anaesthetics
145. Propofol (Diprivan) pharmacokinetics and metabolism - An overview
146. Environmental and work site contamination in anesthesia