Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers

Anesthesiology

Volumn 88, Issue 3, 1998, Pages 601-610

  Ebert, Thomas J ^b   Frink Jr , Edward J ^c   Kharasch, Evan D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c NONE

Author keywords

General anesthesia; Low flow; Nephrotoxicity; Volatile anesthetics

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; BILIRUBIN; CREATINE; FLUORIDE; GLUCOSE; GLUTATHIONE TRANSFERASE; N ACETYL BETA GLUCOSAMINIDASE; NITROGEN; PROTEIN; SEVOFLURANE; UREA;

ADULT; ARTICLE; BLOOD ANALYSIS; CLINICAL TRIAL; CONTROLLED STUDY; DRUG SAFETY; HUMAN; INHALATION ANESTHESIA; INHALATIONAL DRUG ADMINISTRATION; KIDNEY FUNCTION TEST; LIVER FUNCTION TEST; LIVER TOXICITY; MALE; MINIMUM LUNG ALVEOLUS CONCENTRATION; MULTICENTER STUDY; NEPHROTOXICITY; NORMAL HUMAN; PRIORITY JOURNAL; URINALYSIS;

ADULT; ALANINE TRANSAMINASE; ANESTHETICS, INHALATION; BODY TEMPERATURE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHERS; GLUTATHIONE TRANSFERASE; GLYCOSURIA; HUMANS; HYDROCARBONS, FLUORINATED; KIDNEY; KIDNEY DISEASES; LIVER; LIVER DISEASES; METHYL ETHERS; PROTEINURIA; VOLUNTARY WORKERS;

EID: 0031886943     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199803000-00008     Document Type: Article

References (28)

1. Cousins MJ, Mazze RI: Methoxyflurane nephrotoxicity: A study of dose-response in man. JAMA 1973; 225:1611-6
2. Mazze RI, Calverley RK, Smith NT: Inorganic fluoride nephrotoxicity: prolonged enflurane and halothane anesthesia in volunteers. ANESTHESIOLOGY 1977; 46:265-71
3. Frink EJ Jr, Malan TP Jr, Isner RJ, Brown EA, Morgan SB, Brown BR Jr: Renal concentrating function with prolonged sevoflurane or enflurane anesthesia in volunteers. ANESTHESIOLOGY 1994; 80:1019-25
4. Munday IT, Stoddart PA, Jones RM, Lytle J, Cross MR: Serum fluoride concentration and urine osmolality after entlurane and sevoflurane anesthesia in male volunteers, Anesth Analg 1995; 81:553-9
5. Eger EI II, Koblin DD, Rowland T, Ionescu P, Laster MJ, Fang X, Gong D, Sonner J, Weiskoph RB: Nephrotoxicity of sevoflurane versus desflurane anesthesia in volunteers. Anesth Analg 1997; 84:160-8
6. Kharasch ED, Thorning DT, Garton K, Hankins DC, Kilty CG: Role of renal cysteine conjugate b-lyase in the mechanism of compound A nephrotoxicity in rats. ANESTHESIOLOGY 1997; 86:160-71
7. Keller KA, Callan C, Prokocimer P, Delgado-Herrera MS, Friedman MB, Huffman GM, Wooding WL, Cusick PK, Krasula RW: Inhalation toxicology study of a haloalkene degradant of sevoflurane, compound A (PIPE), in Sprague-Dawley rats. ANESTHESIOLOGY 1995; 85:1220-52
8. 2 absorbants during low-flow anesthesia in surgical patients. ANESTHESIOLOGY 1992; 77:1064-9
9. Bito H, Ikeda K: Renal and hepatic function in surgical patients after low-flow sevoflurane or isoflurane anesthesia. Anesth Analg 1996; 82:173-6
10. 2 absorbents during lowflow sevoflurane anesthesia in surgical patients. J Anesth 1995; 9:1-5
11. Bito H, Ikeda K: Closed-circuit anesthesia with sevoflurane in humans. Effects on renal and hepatic function and concentrations of breakdown products with soda lime in the circuit. ANESTHESIOLOGY 1994; 80:71-6
12. Eger EI II, Martin JL, Tinker JH: The safety of sevoflurane has not been adequately established. Anesth Analg 1996; 82:431-2
13. Kharasch ED, Frink EJ Jr, Zager R, Bowdle TA, Artru A, Nogami WM: Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity. ANESTHESIOLOGY 1997; 86:1238-53
14. Bito H, Ikeuchi Y, Ikeda K: Effects of low-flow sevoflurane anesthesia on renal function. Comparison with high-flow sevoflurane anesthesia and low-flow isoflurane anesthesia. ANESTHESIOLOGY 1997; 86:1231-7
15. Bito H, Ikeda K: Long-duration, low-flow sevoflurane anesthesia using two carbon dioxide absorbents. Quantification of degradation products in the circuit. ANESTHESIOLOGY 1994; 81:340-5
16. Munday JT, Ward PM, Foden ND, Jones RM, Van Pelt FNAM, Kenna JG: Sevoflurane degradation by soda lime in a circle breathing system. Anaesthesia 1996; 51:622-6
17. Fang ZX, Kandel L, Laster MJ, Ionescu P, Eger EI II: Factors affecting production of compound A from the interaction of sevoflurane with Baralyme and soda lime. Anesth Analg 1996; 82:775-81
18. Gonsowski CT, Laster MJ, Eger EI II, Ferrell LD, Kerschmann RL: Toxicity of compound A in rats. Effect of increasing duration of administration. ANESTHESIOLOGY 1994; 80:566-73
19. Jin L, Baillie TA, Davis MR, Kharasch ED: Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: Evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate betalyase. Biochem Biophys Res Commun 1995; 210:498-506
20. Frink EJ Jr, Ghantous H, Malan TP, Morgan S, Fernando J, Gandolfi AJ, Brown BR Jr: Plasma Inorganic fluoride with sevoflurane anesthesia: Correlation with indices of hepatic and renal function, Anesth Analg 1992; 74:231-5
21. Levine MF, Sarner J, Lerman J, Davis P, Sikich N, Maloney K, Motoyama E, Cook DR: Plasma inorganic fluoride concentrations after sevoflurane anesthesia in children. ANESTHESIOLOGY 1996; 84:348-53
22. Conzen PF, Nuscheler M, Melotte A, Verhaegen M, Leupolt T, Van Aken H, Peter K: Renal function and strum fluoride concentrations in patients with stable renal insufficiency after anesthesia with sevoflurane or enflurane. Anesth Analg 1995; 81:569-75
23. Kharasch ED, Hankins DC, Thummel KE: Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. ANESTHESIOLOGY 1995; 82:689-99
24. Robinson RR: Isolated proteinuria in asymptomatic patients. Kidney Int 1980; 18:395-406
25. Vittinghus E, Mogensen CE: Graded exercise and protein excretion in diabetic man and the effect of insulin treatment. Kidney Int 1982; 21:725-9
26. Levitt JI: The prognostic significance of proteinuria in young college students. Ann Intern Med 1967; 66:685-96
27. Price RG: Urinary enzymes, nephrotoxicity and renal disease. Toxicology 1982; 23:99-134
28. Iton Y, Numata Y, Morita A, Asano Y, Kawai T: Varied value of urinary N-ucetyl-b-D-glucosaminidase isoenzyme B in males of reproductive age. Kidney Int 1994; 47(Suppl):38-42