Osteogenic protein 1 stimulates cell-associated matrix assembly by normal human articular chondrocytes: Up-regulation of hyaluronan synthase, CD44, and aggrecan

Arthritis and Rheumatism

Volumn 43, Issue 1, 2000, Pages 206-214

  Nishida, Yoshihiro ^a   Knudson, Cheryl B ^a   Eger, Wolfgang ^b   Kuettner, Klaus E ^a   Knudson, Warren ^a  

^a RUSH MEDICAL COLLEGE   (United States)

^b Orthopedic Hospital Rummelsberg   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; HERMES ANTIGEN; HYALURONIC ACID; MESSENGER RNA; OSTEOGENIC PROTEIN 1;

ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; QUANTITATIVE DIAGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGGRECANS; ANTIGENS, CD44; BONE MORPHOGENETIC PROTEINS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; EXTRACELLULAR MATRIX PROTEINS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; GLYCOSYLTRANSFERASES; HUMANS; HYALURONIC ACID; KINETICS; LECTINS, C-TYPE; MEMBRANE PROTEINS; POLYMERASE CHAIN REACTION; PROTEOGLYCANS; RNA, MESSENGER; TRANSFERASES; TRANSFORMING GROWTH FACTOR BETA; XENOPUS PROTEINS;

EID: 0034042705     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200001)43:1<206::AID-ANR25>3.0.CO;2-1     Document Type: Article

References (47)

1. Kuettner KE. Osteoarthritis: cartilage integrity and homeostasis. In: Klippel JH, Dieppe PA, editors. Rheumatology. St. Louis: Mosby-Year Book Europe Limited; 1994. p. 6.1-6.16.
2. Knudson CB. Hyaluronan receptor-directed assembly of chondrocyte pericellular matrix. J Cell Biol 1993;120:825-34.
3. Knudson W, Aguiar DJ, Hua Q, Knudson CB. CD44-anchored hyaluronan-rich pericellular matrices: an ultrastructural and biochemical analysis. Exp Cell Res 1996;228:216-28.
4. Chow G, Nietfeld JJ, Knudson CB, Knudson W. Antisense inhibition of chondrocyte CD44 expression leading to cartilage chondrolysis. Arthritis Rheum 1998;41:1411-9.
5. Urist MR. Bone: formation by auto-induction. Science 1965;273: 893-9.
6. Reddi AH, Huggins C. Biochemical sequences in the transformation of normal fibroblasts in adolescent rats. Proc Natl Acad Sci U S A 1972;69:1601-5.
7. Wang EA, Rosen V, Cordes P, Hewick RM, Kriz MJ, Luzenberg DP, et al. Purification and characterization of other distinct bone-inducing factors. Proc Natl Acad Sci U S A 1988;85:9484-8.
8. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, et al. Novel regulators of bone formation: molecular clones and activities. Science 1988;242:1528-34.
9. Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, et al. Identification of transforming growth factor-β family members present in bone-inductive protein purified from bovine tissue. Proc Natl Acad Sci U S A 1990;87:9843-7.
10. Luyten FP, Cunningham NS, Ma S, Muthukkumaran N, Hammonds RG, Nevins WS, et al. Purification and partial amino acid sequence of osteogenin, a protein initiating bone differentiation. J Biol Chem 1989;263:13377-80.
11. Sampath TK, Coughlin JE, Whetstone RM, Banach D, Corbett C, Ridge RJ, et al. Bovine osteogenic protein 1 is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-β superfamily. J Biol Chem 1990;265:13198-205.
12. Ozkaynak E, Rueger DC, Drier EA, Corbett C, Ridge RJ, Sampath TK, et al. OP-1 cDNA encodes an osteogenic protein in the TGF-β family. EMBO J 1990;9:2085-93.
13. Ozkaynak E, Schnegelsberg PNJ, Jin DF, Clifford GM, Waren FD, Drier EA, et al. Osteogenic protein-2. J Biol Chem 1992;267:25220-7.
14. Reddi AH. Cell biology and biochemistry of endochondral bone development. Collagen Relat Res 1981;1:209-26.
15. Sampath TK, Maliakal JC, Hauschka PV, Jones WK, Sasak H, Tucker RF, et al. Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J Biol Chem 1992;67:20352-62.
16. Takuwa YC, Ohse C, Wang EA, Wozney JM, Yamashita K. Bone morphogenetic protein-2 stimulates ALP activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1. Biochem Biophys Res Commun 1991;174:96-101.
17. Chen TL, Bates RL, Dudley ARG, Hammonds J, Amento EP. Bone morphogenetic protein-2b stimulation of growth and osteogenic phenotype in rat osteoblast-like cells: comparison with TGF-β. J Bone Miner Res 1991;6:1387-93.
18. Asahina I, Sampath TK, Hauschka PV. Human osteogenic protein-1 induces chondroblastic, osteoblastic and/or adipocytic differentiation of clonal murine target cells. Exp Cell Res 1996;222:38-47.
19. Yamaguchi A, Katagiri T, Ikeda T, Wozney JM, Rosen V, Wang EA, et al. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J Cell Biol 1991;113:681-7.
20. Katagiri T, Yamaguchi A, Ikeda T, Yoshiki S, Wozney JM, Rosen V, et al. The non-osteogenic mouse pluripotent cell line C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem Biophys Res Commun 1990;172:295-9.
21. Thies RS, Bauduy M, Ashton BA, Kurzberg L, Wozney JM, Rosen V. Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology 1992;130:1318-24.
22. Iwasaki M, Nakahara H, Nakase T, Kimura T, Takaoka K, Caplan AI, et al. Bone morphogenetic protein-2 stimulates osteogenesis, but does not affect chondrogenesis in osteochondrogenic differentiation of periosteum-derived cells. J Bone Miner Res 1994;9: 1195-204.
23. Vukicevic S, Luyten FP, Reddi AH. Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin. Proc Natl Acad Sci U S A 1989;86:8793-7.
24. Chen P, Carrington JL, Hammonds RG, Reddi AH. Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2B (BMP-2B) and modulation by transforming growth factor β1 and β2. Exp Cell Res 1991;195:509-15.
25. Luyten FP, Yu YM, Yanagishita M, Vukicevic S, Hammonds RG, Reddi AH. Natural bovine osteogenin and recombinant human bone morphogenic protein-2B are equipotent in the maintenance of proteoglycans in bovine articular cartilage explant cultures. J Biol Chem 1992;264:3691-5.
26. Dieudonne SC, Semeins CM, Goci SW, Vukicevic S, Nulend JK, Sampath TK, et al. Opposite effects of osteogenic protein and transforming growth factor-β on chondrogenesis in cultured long bone rudiments. J Bone Miner Res 1994;9:771-80.
27. Chen P, Vukicevic S, Sampath TK, Luyten FP. Bovine articular chondrocytes do not undergo hypertrophy when cultured in the presence of serum and osteogenic protein-1. Biochem Biophys Res Commun 1993;197:1253-9.
28. Lietman SA, Yanagishita M, Sampath TK, Reddi AH. Stimulation of proteoglycan synthesis in explants of porcine articular cartilage by recombinant osteogenic protein-1 (bone morphogenetic protein-7). J Bone Joint Surg Am 1997;79-A:1132-7.
29. Flechtenmacher J, Huch K, Thonar EJMA, Mollenhauer J, Davies SR, Schmid TM, et al. Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes. Arthritis Rheum 1996;39:1896-904.
30. Aydelotte MB, Kuettner KE. Differences between subpopulations of cultured bovine articular chondrocytes. Connect Tissue Res 1988;18:223-34.
31. Hauselmann HJ, Aydelotte MB, Schumacher BL, Kuettner KE, Gitelis SH, Thonar EJMA. Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads. Matrix 1992;12:130-6.
32. Mok SS, Masuda K, Hauselmann HJ, Aydelotte MB, Thonar EJMA. Aggrecan synthesized by mature bovine chondrocytes suspended in alginate. J Biol Chem 1994;269:33021-7.
33. Masuda K, Shirota H, Thonar EJMA. Quantification of 35S-labeled proteoglycans complexed to alcian blue by rapid filtration in multiwell plates. Anal Biochem 1994;217:167-75.
34. Chow G, Knudson CB, Homandberg G, Knudson W. Increased CD44 expression in bovine articular chondrocytes by catabolic cellular mediators. J Biol Chem 1995;270:27734-41.
35. Diviacco S, Norio P, Zentilin L, Menzo S, Clementi M, Biamonti G, et al. A novel procedure for quantitative polymerase chain reaction by coamplification of competitive templates. Gene 1992; 122:313-20.
36. Celi F, Zenilman M, Shuldiner A. A rapid and versatile method to synthesize internal standards for competitive PCR. Nucleic Acids Res 1993;21:1047.
37. Haapala J, Lammi MJ, Inkinen R, Parkkinen JJ, Agren UM, Arokoski J, et al. Coordinated regulation of hyaluronan and aggrecan content in the articular cartilage of immobilized and exercised dogs. J Rheumatol 1996;22:1586-93.
38. Knudson W, Knudson CB. Assembly of a chondrocyte-like pericellular matrix on non-chondrogenic cells. J Cell Sci 1991;99:227-35.
39. Knudson W, Bartnik E, Knudson CB. Assembly of pericellular matrices by COS-7 cells transfected with CD44 homing receptor genes. Proc Natl Acad Sci U S A 1993;90:4003-7.
40. Itano N, Kimata K. Expression cloning and molecular characterization of HAS protein, eukaryotic hyaluronan synthase. J Biol Chem 1996;271:9875-8.
41. Itano N, Kimata K. Molecular cloning of human hyaluronan synthase. Biochem Biophys Res Commun 1996;222:816-20.
42. Shyjan AM, Heldin P, Butcher EC, Yoshino T, Briskin MJ. Functional cloning of the cDNA for a human hyaluronan synthase. J Biol Chem 1996;271:23395-9.
43. Spicer AP, Augustine ML, McDonald JA. Molecular cloning and characterization of a putative mouse hyaluronan synthase. J Biol Chem 1996;271:23400-6.
44. Watanabe K, Yamaguchi Y. Molecular identification of a putative human hyaluronan synthase. J Biol Chem 1996;271:22945-8.
45. Spicer AP, Olson JS, McDonald JA. Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase. J Biol Chem 1997;272:8957-61.
46. Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, et al. Chromosomal localization of the human and mouse hyaluronan synthase genes. Genomics 1997;41:493-7.
47. Nishida Y, Knudson CB, Nietfeld JJ, Margulis A, Knudson W. Antisense inhibition of hyaluronan synthase-2 in human articular chondrocytes inhibits proteoglycan retention and matrix assembly. J Biol Chem 1999; 274:21893-9.