Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it

Chemico-Biological Interactions

Volumn 110, Issue 3, 1998, Pages 139-158

  Vermeulen, N P E ^a   Commandeur, J N M ^a   Groot, E J ^a   Wormhoudt, L W ^a   Ramnatshing, S ^a   Li, Q J ^b   Brakenhoff, J P G ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Chemoprotection; DEP isocyanate; Ebselen; Fotemustine; Glutathione; Hepatocyte; Mechanisms of cytotoxicity; Metabolism; N acetyl L cysteine; Vitamin E

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; EBSELEN; FOTEMUSTINE; GLUTATHIONE; ISOCYANATE; NITROSOUREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROTECTION; CYTOTOXICITY; DNA ALKYLATION; DRUG METABOLISM; DRUG POTENCY; ENZYME ACTIVITY; LIPID PEROXIDATION; LIVER TOXICITY; MELANOMA; NEPHROTOXICITY; NONHUMAN; RAT; THROMBOCYTOPENIA;

ACETYLCYSTEINE; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL SURVIVAL; CELLS, CULTURED; GLUTATHIONE; GLUTATHIONE DISULFIDE; KINETICS; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; LIVER; MALE; NITROSOUREA COMPOUNDS; ORGANOPHOSPHORUS COMPOUNDS; RATS; RATS, WISTAR; SULFHYDRYL REAGENTS; VITAMIN E;

EID: 0032478592     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(98)00004-0     Document Type: Article

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