Targeted disruption of fibronectin-integrin interactions in human gingival fibroblasts by the RI protease of Porphyromonas gingivalis W50

Infection and Immunity

Volumn 67, Issue 4, 1999, Pages 1837-1843

  Scragg, M A ^a   Cannon, S J ^a   Rangarajan, M ^a   Williams, D M ^a   Curtis, M A ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN; INTEGRIN; PROTEINASE;

ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; CELL INVASION; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; PATHOGENESIS; PERIODONTAL DISEASE; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

EID: 0033068080     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.4.1837-1843.1999     Document Type: Article

References (33)

1. Aduse-Opoku, J., J. Muir, J. M. Slaney, M. Rangarajan, and M. A. Curtis. 1995. Characterization, genetic analysis, and expression of a protease antigen (PrpR1) of Porphyromonas gingivalis W50. Infect. Immun. 63:4744-4754.
2. Birkedal-Hansen, H., R. E. Taylor, J. J. Zambon, P. K. Barwa, and M. E. Neiders. 1988. Characterization of collagenolytic activity from strains of Bacteroides gingivalis. J. Periodontal Res. 23:258-264.
3. Birkedal-Hansen, H., B. R. Wells, H. Y. Lin, P. W. Caulfield, and R. E. Taylor. 1984. Activation of keratinocyte-mediated collagen (type I) breakdown by suspected human periodontopathogen. Evidence of a novel mechanism of connective tissue breakdown. J. Periodontal Res. 19:645-650.
4. Bretscher, M. S. 1989. Endocytosis and recycling of the fibronectin receptor in CHO cells. EMBO J. 8:1341-1348.
5. Collinson, L. M., M. Rangarajan, and M. A. Curtis. 1998. Altered expression and modification of proteases from an avirulent mutant of Porphyromonas gingivalis W50 (W50/BE1). Microbiology 144:2487-2496.
6. Cridland, J. C., V. Booth, F. P. Ashley, M. A. Curtis, R. F. Wilson, and P. Shepherd. 1994. Preliminary characterisation of antigens recognised by monoclonal antibodies raised to Porphyromonas gingivalis and by sera from patients with periodontitis. J. Periodontal Res. 19:645-650.
7. Curtis, M. A. 1997. Analysis of the protease and adhesin domains of the PrpR1 of Porphyromonas gingivalis. J. Periodontal Res. 32:133-139.
8. Curtis, M. A., J. Aduse-Opoku, J. M. Slaney, M. Rangarajan, V. Booth, J. Cridland, and P. Shepherd. 1996. Characterization of an adherence and antigenic determinant of the ArgI protease of Porphyromonas gingivalis which is present on multiple gene products. Infect. Immun. 64:2532-2539.
9. Curtis, M. A., M. Ramakrishnan, and J. M. Slaney. 1993. Characterization of the trypsin-like enzymes of Porphyromonas gingivalis W83 using a radio-labelled active-site-directed inhibitor. J. Gen. Microbiol. 139:949-955.
10. DeCarlo, A. A., L. J. Windsor, M. K. Bodden, G. J. Harber, B. Birkedal-Hansen, and H. Birkedal-Hansen. 1997. Activation and novel processing of matrix metalloproteinases by a thiol-proteinase from the oral anaerobe Porphyromonas gingivalis. J. Dent. Res. 76:1260-1270.
11. 1-integrin but lack an intracellular pool of mature subunit. Eur. J. Biochem. 199:25-33.
12. Fletcher, H. M., H. A. Schenkein, R. M. Morgan, K. A. Bailey, C. R. Berry, and F. L. Macrina. 1995. Virulence of a Porphyromonas gingivalis W83 mutant defective in the prtH gene. Infect. Immun. 63:1521-1528.
13. Isberg, R. R., and G. Tran Van Nhieu. 1994. Binding and internalization of microorganisms by integrin receptors. Trends Microbiol. 2:10-14.
14. Kodawaki, T., M. Yoneda, K. Okamoto, K. Maeda, and K. Yamamoto. 1994. Purification and characterization of a novel arginine-specific cysteine proteinase (argingipain) involved in the pathogenesis of periodontal disease from the culture supernatant of Porphyromonas gingivalis. J. Biol. Chem. 269:21371-21378.
15. Kontani, M., S. Kimura, I. Nakagawa, and S. Hamada. 1997. Adherence of Porphyromonas gingivalis to matrix proteins via a fimbrial cryptic receptor exposed by its own arginine-specific protease. Mol. Microbiol. 24:1179-1187.
16. Kontani, M., H. Ono, H. Shibata, Y. Okamura, T. Tanaka, T. Fujiwara, S. Kimura, and S. Kamada. 1996. Cysteine protease of Porphyromonas gingivalis 381 enhances binding of fimbriae to cultured human fibroblasts and matrix proteins. Infect. Immun. 64:756-762.
17. Marsh, P. D., A. S. McKee, A. S. McDermid, and A. B. Dowsett. 1989. Ultrastructure and enzyme activities of a virulent and an avirulent variant of Bacteroides gingivalis W50. FEMS Microbiol. Lett. 59:181-186.
18. McKee, A. S., A. S. McDermid, R. Wait, A. Baskerville, and P. D. Marsh. 1988. Isolation of colonial variants of Bacteroides gingivalis W50 with a reduced virulence. J. Med. Microbiol. 27:59-64.
19. Patti, J. M., B. L. Allen, M. J. McGavin, and M. Höök. 1994. MSCRAMM-mediated adherence of microorganisms to host tissues. Annu. Rev. Microbiol. 48:585-617.
20. Pike, R. N., J. Potempa, W. McGraw, T. H. T. Coetzer, and J. Travis. 1996. Characterization of the binding activities of proteinase-adhesin complexes from Porphyromonas gingivalis. J. Bacteriol. 178:2876-2882.
21. Potempa, J., R. Pike, and J. Travis. 1995. The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain. Infect. Immun. 63:1176-1182.
22. Rangarajan, M., J. Aduse-Opoku, J. M. Slaney, K. A. Young, and M. A. Curtis. 1997. The prpR1 and prR2 arginine-specific protease genes of Porphyromonas gingivalis W50 produce five biochemically distinct enzymes. Mol. Microbiol. 23:955-965.
23. Rangarajan, M., S. J. M. Smith, S. U, and M. A. Curtis. 1997. Biochemical characterization of the arginine-specific proteases of Porphyromonas gingivalis W50 suggests a common precursor. Biochem. J. 323:701-709.
24. Scragg, M. A., S. J. Cannon, and D. M. Williams. 1996. The secreted products of Porphyromonas gingivalis alter human gingival fibroblast morphology by selective damage to integrin-substrate interactions. Microb. Ecol. Health Dis. 9:167-179.
25. Shah, H. N., S. V. Seddon, and S. E. Gharbia. 1989. Studies on the virulence properties and metabolism of pleiotropic mutants of Porphyromonas gingivalis (Bacteroides gingivalis) W50. Oral Microbiol. Immunol. 4:19-23.
26. Slots, J., and M. A. Listgarten. 1988. Bacteroides gingivalis, Bacteroides intermedius and Actinobacillus actinomycetemcomitans in human periodontal diseases. J. Clin. Periodontol. 15:85-93.
27. Smalley, J. W., A. J. Birss, and C. A. Shuttleworth. 1988. The degradation of type 1 collagen and human plasma fibronectin by the trypsin-like enzyme and extracellular membrane vesicles of Bacteroides gingivalis W50. Arch. Oral Biol. 33:323-329.
28. Sorsa, T., T. Ingman, K. Suomalainen, M. Haapasalo, Y. T. Konttinen, O. Lindy, H. Saari, and V.-J. Ditto. 1992. Identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases. Infect. Immun. 60:4491-4495.
29. Travis, J., R. Pike, T. Imamura, and J. Potempa. 1997. Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis. J. Periodontal Res. 32:120-125.
30. Ditto, V.-J., M. Haapasalo, T. Laasko, and T. Salo. 1988. Degradation of basement membrane collagen by proteases from some anaerobic oral microorganisms. Oral Microbiol. Immunol. 3:97-102.
31. Uitto, V.-J., H. Larjava, J. Heino, and T. Sorsa. 1989. A protease of Bacteroides gingivalis degrades cell surface and matrix glycoproteins of cultured gingival fibroblasts and induces secretion of collagenase and plasminogen activator. Infect. Immun. 57:213-218.
32. Werb, Z., P. M. Tremble, O. Behrendtsen, E. Crowley, and C. H. Damsky. 1989. Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J. Cell Biol. 109:877-889.
33. Van Winkelhoff, A. J., T. J. M. Van Steenbergen, and J. de Graaff. 1988. The role of black-pigmented Bacteroides in human oral infections. J. Clin. Periodontol. 15:145-155.