Evidence for prolonged cell-surface contact of acetyl-LDL before entry into macrophages

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 7, 1997, Pages 1421-1431

  Zha, Xiaohui ^a   Tabas, Ira ^a   Leopold, Philip L ^a   Jones, Nancy L ^c   Maxfield, Frederick R ^b  

^a New York Presbyterian Columbia University Medical Center   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Endocytosis; Microvilli; Scavenger receptors

Indexed keywords

ACETYL LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ARTICLE; CELL SURFACE; CELL TRANSPORT; ELECTRON MICROSCOPY; ENDOSOME; FEMALE; LIPID TRANSPORT; LYSOSOME; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030804676     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.7.1421     Document Type: Article

References (8)

1. Gerrity RG. The role of the monocyte in atherogenesis, I: transition of blood-borne monocytes into foam cells in fatty streak formation. Am J Pathol. 1981;103:181-190.
2. Faggioto A, Ross R, Harker L. Studies of hypercholesterolemia in the nonhuman primate, I: changes that lead to fatty streak formation. Atherosclerosis. 1984;4:323-340.
3. Brown MS, Goldstein JL. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem. 1983;52:223-261.
4. Mahley RM, Innerarity T, Brown MS, Ho YK, Goldstein JL. Cholesteryl ester synthesis in macrophages: stimulation by β-VLDL from cholesterol-fed animals of several species. J Lipid Res. 1980;21:970-980.
5. Goldstein JL, Brown MS. Lipoprotein metabolism in macrophages: implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem. 1977;46:890-930.
6. Tabas I. The stimulation of the cholesterol esterification pathway by atherogenic lipoproteins in macrophages. Curr Opin Lipidol. 1995;6:260-268.
7. Chang CCY, Doolittle GM, Chang TY. Cycloheximide sensitivity in regulation of acyl coenzyme A:cholesterol acyltransferase activity in Chinese hamster ovary cells, I: effect of exogenous sterols. Biochemistry. 1986;25:1693-1699.
8. Chang CCY, Chang TY. Cycloheximide sensitivity in regulation of acyl coenzyme A:cholesterol acyltransferase activity in Chinese hamster ovary cells, II: effect of sterol endogenously synthesized. Biochemistry. 1986;25:1700-1706.