A single amino-acid in the TM1 domain is an important determinant of the desensitization kinetics of recombinant human and guinea pig α-homomeric 5-hydroxytryptamine type 3 receptors

Molecular Pharmacology

Volumn 59, Issue 4, 2001, Pages 844-851

  Lobitz, N ^a   Gisselmann, G ^a   Hatt, H ^a   Wetzel, C H ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN 3 AGONIST; SEROTONIN 3 RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; CHANNEL GATING; DESENSITIZATION; GUINEA PIG; HUMAN; HUMAN CELL; NEUROPROTECTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SYNAPTIC TRANSMISSION;

EID: 0035057060     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.4.844     Document Type: Article

References (35)

1. A molecular scheme for the reaction between gamma-aminobutyric acid and the most abundant chloride channel on crayfish deep extensor abdominal muscle
2. 3 receptor in mammalian brain: A new target for the development of psychotropic drugs?
3. 3 receptor in CNS disorders
4. 3 receptor gating
5. 3 β-subunit is a major determinant of serotonin-receptor function
6. 3 receptors are membrane ion channels
7. Desensitization of acetylcholine receptors in BC3H-1 cells
8. Rapid activation and desensitization of transmitter-liganded receptor channels by pulses of agonists
9. Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities
10. Backbone mutations in transmembrane domains of a ligand-gated ion channel: Implications for the mechanism of gating
11. Desperately seeking subunits: Are native 5-HT3 receptors really homomeric complexes?
12. Kinetic constants of the acetylcholine (ACh) receptor reaction deduced from the rise in open probability after steps in ACh concentration
13. Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic
14. Mammalian cell expression
15. 3A receptors
16. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
17. 3 receptors in rodents
18. 3 receptor A subunit
19. Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization
20. Functional properties of a cloned 5-hydroxy-tryptamine ionotropic receptor subunit: Comparison with native mouse receptors
21. Acceleration of GABA-dependent desensitization by mutating threonine 266 to alanine of the alpha 6 subunit of rat GABAA receptors
22. 3 subtype of serotonin receptor in primary cultures of rodent hippocampus
23. 3 receptor cDNA and its splice variants from guinea pig
24. Both open and closed NMDA receptor channels desensitize
25. 3 receptor, a serotonin-gated ion channel
26. Comparison of fast responses to serotonin and 2-methyl-serotonin in voltage-clamped N1E-115 neuroblastoma cells
27. 3 receptor: Heterogeneity in distribution and function among species
28. 3 receptors
29. Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor
30. 3 receptors in developing visual cortex
31. 3 receptor gene and functional expression of two splice variants
32. 3 receptors as cation channels
33. Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes
34. 3 receptor
35. 3 receptor channels in dissociated rat superior cervical ganglion neurons