Intramuscular electroporation delivery of IL-12 gene for treatment of squamous cell carcinoma located at distant site

Cancer Gene Therapy

Volumn 8, Issue 3, 2001, Pages 151-157

  Hanna, E ^a   Zhang, X ^a   Woodlis, J ^a   Breau, R ^a   Suen, J ^a   Li, S ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Electroporation; Gene therapy; IL 12; Muscle; Squamous cell carcinoma

Indexed keywords

INTERLEUKIN 12; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER THERAPY; CONTROLLED STUDY; CORRELATION FUNCTION; ELECTROPORATION; EXPRESSION VECTOR; FEMALE; GENE TARGETING; GENE THERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SQUAMOUS CELL CARCINOMA; T LYMPHOCYTE SUBPOPULATION; TIBIALIS ANTERIOR MUSCLE; TIBIALIS POSTERIOR MUSCLE; TUMOR LOCALIZATION;

ANIMALIA;

EID: 0035052031     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700287     Document Type: Article

References (21)

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2. Canarypox virus-mediated interleukin 12 gene transfer into murine mammary adenocarcinoma induces tumor suppression and long-term antitumoral immunity
3. Cytokines (IFNs, TNF-alpha, IL-2 and IL-12) and animal models of cancer
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7. IL-12 deaths: Explanation and a puzzle
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9. Long-term duration of plasmid DNA and foreign gene expression in mouse muscle
10. Gene transfer into muscle by electroporation in vivo
11. Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation
12. Intratumoral delivery of IL-12 gene by polyvinyl polymeric vector system to murine renal and colon carcinoma results in potent antitumor immunity
13. Increased level and duration of expression in muscle by co-expression of a transactivator
14. Inhibition of growth of a murine squamous cell carcinoma by a cyclooxygenase inhibitor increases leukotriene B4 production
15. Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle
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17. Cytokine-induced tumor immunogenicity: From exogenous cytokines to gene therapy
18. Role of interferon-γ in mediating the antitumor efficacy of interleukin-12
19. Recombinant IL-12 administration induces tumor regression in association with IFN-γ production
20. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN - In vivo
21. CD4 T cells inhibit in vivo the CD8-mediated immune response against murine colon carcinoma cells transduced with interleukin-12 genes