Actions of the systemically active metabotropic glutamate antagonist MPEP on sensory responses of thalamic neurones

Neuropharmacology

Volumn 40, Issue 5, 2001, Pages 639-644

  Binns, K E ^a   Salt, T E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Electroencephalogram; In vivo electrophysiology; Metabotropic glutamate receptors; Pain; Somatosensory synapses; Ventrobasal thalamus

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST; RECEPTOR SUBTYPE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG RECEPTOR BINDING; HEART RATE; MALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SLOW BRAIN WAVE; THALAMUS; THERMAL STIMULATION;

ACTION POTENTIALS; ANIMALS; ELECTROENCEPHALOGRAPHY; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; HEART RATE; MALE; NEURONS, AFFERENT; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, KAINIC ACID; RECEPTORS, METABOTROPIC GLUTAMATE; THALAMUS;

EID: 0035049968     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00202-1     Document Type: Article

References (34)

1. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction
2. Distribution and developmental changes in metabotropic glutamate receptor messenger RNA expression in the rat lumbar spinal cord
3. Anti-hyperalgesic effects of the novel metabotropic glutamate receptor 5 antagonist Methylphenylethynlpyridine, in rat models of inflammatory pain
4. Evaluation of the activity of a novel metabotropic glutamate receptor antagonist (±)-2-amino-2-(3-cis and trans-carboxycyclobutyl-3-(9-thioxanthyl acid) in the in vitro neonatal spinal cord and in an in vivo pain model
5. Pharmacology and functions of metabotropic glutamate receptors
6. (R,S)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5 but not mGlu1 receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus
7. Thalamic NMDA receptors and nociceptive sensory synaptic transmission
8. Mediation of thalamic sensory responses in vivo by ACPD-activated excitatory amino acid receptors
9. The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception
10. In vivo antinociceptive activity of anti-rat mGluR(1) and mGluR(5) antibodies in rats
11. 2-Methyl-6-(Phenylethynyl)-Pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
12. Neurones responding to noxious stimulation in VB complex and caudal adjacent regions in the thalamus of the rat
13. Metabotropic glutamate receptors in superficial laminae of the rat dorsal horn
14. Neuronal activity in the ventrobasal complex of the thalamus and in trigeminal main sensory nucleus during EEG desynchronization in anesthetized rats
15. Responses of neurons in primate ventral posterior lateral nucleus to noxious stimuli
16. Molecular diversity of glutamate receptors and implications for brain function
17. Differential distribution of metabotropic glutamate receptor subtype mRNAs in the thalamus of the rat
18. Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons
19. Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells
20. Involvement of the rat ventrobasal thalamic complex in the sensory-discriminative aspects of pain: Electrophysiological and anatomical data
21. Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain
22. Excitatory amino acid receptors and synaptic transmission in the rat ventrobasal thalamus
23. Contributions of mGlu1 and mGlu5 receptors to interactions with N-methyl-D-aspartate receptor-mediated responses and nociceptive sensory responses of rat thalamic neurones
24. The function of metabotropic excitatory amino acid receptors in synaptic transmission in the thalamus: Studies with novel phenylglycine antagonists
25. Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel mGluR1 selective antagonist (S) 2-methyl-4-carboxy-phenylglycine
26. Antagonism of thalamic metabotropic glutamate (mGlu) receptor and nociceptive responses by the novel mGlu5 antagonist MPEP
27. Antagonism of group I metabotropic glutamate receptor and sensory responses by novel selective mGlu5 and mGlu1 antagonists in the thalamus
28. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain
29. Basic mechanisms of cerebral rhythmic activities
30. Thalamocortical oscillations in the sleeping and aroused brain
31. mGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord: A developmental study
32. Nociceptive body representation in the nucleus ventralis posterolateralis of cat thalamus
33. Antisense ablation of type I metabotropic glutamate receptor mGluR(1) inhibits spinal nociceptive transmission