The potential role of tocopherol in asthma and allergies: Modification of the leukotriene pathway

BioDrugs

Volumn 15, Issue 2, 2001, Pages 81-86

  Centanni, S ^a   Santus, P ^a   Dimarco, F ^a   Fumagalli, F ^a   Zarini, S ^a   Sala, A ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; FORMYLMETHIONYLLEUCYLPHENYLALANINE; HYDROPEROXIDE; ICOSATETRAENOIC ACID; LEUKOTRIENE; LEUKOTRIENE B4; LEUKOTRIENE C4; LEUKOTRIENE D4; LEUKOTRIENE E4; PEPTIDOLEUKOTRIENE; PHOSPHOLIPASE A2; TOCOPHEROL;

ALLERGY; ARACHIDONIC ACID METABOLISM; ASTHMA; HUMAN; LEUKOCYTE ACTIVATION; NONHUMAN; OXIDATION REDUCTION STATE; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

EID: 0035046628     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-200115020-00002     Document Type: Review

References (57)

1. 2
2. Prostaglandins and thromboxane
3. 5-Lipoxygenase
4. Arachidonate 15-lipoxygenase
5. Identification and isolation of a membrane protein necessary for leukotriene production
6. Leukotriene C: A slow reacting substance (SRS) from murine mastocytoma cells
7. Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro
8. 4
9. Leukotrienes are potent constrictors of human bronchi
10. Slow reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle
11. 4 on isolated human airway smooth muscle
12. Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxy eicosanoic acid
13. Transformation of arachidonic acid and homo-τ-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxyacids from novel lipoxygenases
14. 4) on the guinea-pig lung
15. 4, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes
16. Leukotrienes promote plasma leakage and leukocyte adhesion in post capillary venules: In vivo effects with relevance to the acute inflammatory response
17. 4 - A stereospecific stimulator for release of lysosomal enzymes from neutrophils
18. 4
19. 4 in the immune system
20. 4 enhances IL-4-induced IgE production from normal human lymphocytes
21. 4 in normal and asthmatic subjects
22. The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin
23. Indirect evidence of nasal inflammation assessed by titration of inflammatory mediators and enumeration of cells in nasal secretion of patients with chronic rhinitis
24. 4 release in upper respiratory mucosa during natural exposure to ragweed in ragweed-sensitive children
25. Prostaglandins, leukotrienes and other arachidonic acid metabolites in nasal polyps and nasal mucosa
26. Petpide leukotriene release after antigen challenge in patients sensitive to ragweed
27. 4 in allergic rhinitis
28. 4 in grass pollen-induced rhinitis
29. Acute chronic effects of a 5-lipoxygenase inhibitor in asthma: A 6-month randomized multicenter trial
30. Lung function improvement in asthma with a cysteinyl-leukotriene receptor antagonist
31. Enhanced alveolar cell luminol-dependent chemiluminescence in asthma
32. Eosinophil and neutrophil chemiluminescence in patients with atopic asthma and in healthy subjects
33. Increased oxygen species generation in blood monocytes of asthmatic patients
34. Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients
35. Altered lung antioxidant status in patients with mild asthma
36. Lowered glutathione peroxidase activity in asthmatic patients with food and aspirin intolerance
37. Selenium status in relation to glutathione peroxidase activity in aspirin-sensitive asthma
38. Reduced selenium status of patients with asthma
39. Reduced selenium in asthmatic subjects in New Zeland
40. New concepts in the pathogenesis of bronchial hyperresponsiveness and asthma
41. Selenium, glutathione peroxidase and asthma
42. 4 synthase activities
43. Vitamin E and free radical peroxidation of lipids
44. Biochemical function of selenium and its relation to vitamin E
45. Mechanism of action of selenium and vitamin E in protection of biological membranes
46. Vitamin E modulates the lipoxygenation of arachidonic acid in leukocytes
47. Consequences of vitamin E deficiency on the phagocytic and oxidative functions of the rat polymorphonuclear leukocyte
48. Vitamin E: An inhibition of the platelet release reaction
49. The measurement of nanograms of tocopherol from needle aspiration biopsies of adipose tissue: Normal and abetalipoproteinemic subjects
50. Vitamin E and vitamin C inhibit arachidonate-induced aggregation of human peripheral blood leukocytes in vitro
51. Inhibition of 5-lipoxygenase by vitamin E
52. 2 activity in rat lung and liver
53. Tocopherol inhibits leukotriene production by human neutrophils in asthmatic subjects
54. 4
55. 4 from human leukocytes
56. 4 excretion in genetic vitamin E deficiency
57. 4 and 11-dehydro-TXBZ excretion in asthmatic patients