Cardiac toxicity of resibufogenin: Electrophysiological evidence

Acta Pharmacologica Sinica

Volumn 22, Issue 4, 2001, Pages 289-297

  Xie, J T ^a   Dey, L ^a   Wu, J A ^a   Lowell, T K ^a   Yuan, C S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Arrhythmia; Bufanolides; Digitalis; Electrophysiology; Purkinje fibers

Indexed keywords

BUFALIN; BUFOGENIN; BUFOTALIN; CARDIOTONIC AGENT; CINOBUFAGIN; DIGITOXIGENIN; UNCLASSIFIED DRUG;

ANIMAL CELL; CARDIOTOXICITY; CHEMICAL STRUCTURE; CHINESE MEDICINE; DRUG FORMULATION; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HUMAN; HUMAN CELL; NONHUMAN; REVIEW; UNITED STATES;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; ATROPINE; BUFANOLIDES; CARDIOTONIC AGENTS; ELECTROPHYSIOLOGY; HUMANS; PURKINJE FIBERS;

EID: 0035045943     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (55)

1. Biochemical studies on the cardiotonic action of senso
2. Simultaneous determination of bufadienolides in the traditional Chinese medicine preparation, Liu shen wen, by liquid chromatography
3. Bufogenin
4. Determination of resibufogenin and cinobufagin in heart-protecting musk pill by HPLC
5. Falsely elevated serum digitoxin concentrations due to cross-reactivity of waterextractable digitoxin-like immunoreactivity of Chinese medicine Chan SU: Elimination of interference by use of a chemiluminescent assay
6. Positive and negative interference of the Chinese medicine Chan Su in serum digoxin measurement. Elimination of interference by using a monoclonal chemiluminescent digoxin assay or monitoring free digoxin concentration
7. Chansu
8. Digitalis-like and vasoconstrictor effects of endogenous digoxin-like factor(s) from the venom of Bufo marinus toad
9. Metabolism and disposition of kyushin, a drug containing senso (ch'an su)
10. Pharmacological actions of 'Kyushin', a drag containing toad venom: Cardiotonic and arrhythmogenic effects, and excitatory effect on respiration
11. Treatment of toad venom poisoning with digoxin-specific Fab fragments
12. Digitalis toxicity caused by toad venom
13. Biologic intoxication due to digitalis-like substance after ingestion of cooked toad soup
14. Deaths associated with a purported aphrodisiac New York City
15. Identification of a ouabain-like compound in toad skin and plasma as a bufodienolide derivative
16. The First Tianjin Factory for Chinese Herbal Medicine, Dept of Biology, Nankai University. The separation and extraction of resibufogenin
17. Synthesis of bufadienlides, the synthesis of bufalin and RBG
18. Plasma potassium may protect sodium pumps of toad heart from an endogenous inhibitor
19. The chemistry and pharmacology of senso (Ch'an su)
20. Experimental and clinical studies of resibufogenin
21. The effects of resibufogenin on vasopressor and antishock
22. The pharmacological studies of Chinese traditional drug, Resibufogenin
23. Pharmacology of the principles isolated from senso (Ch'an Su), the dried venom of the Chinese toad (V). Action of bufogenins and allied compounds on respiratory, blood pressure and heart
24. Some effects of RBG: An aglycone of animal origin
25. The monophasic action potential technique and its application in cardiac electropharmacology
26. The effect of RBG on the electrophysiologic properties of canine myocardial and Purkinje fibers
27. Effect of RBG on action potential of myocardial fiber of dog and guineapig
28. RBG-induced delayed afterdepolarization in rabbit heart in situ
29. Induction of delayed afterdepolarizations and triggered arrhythmias in isolated Purkinje fibers: Comparison of RBG and acetylstrophanthidin
30. The electrophysiological action of resibufogenin on mammalian cardiac fibers
31. Effects of resibufogenin, from toad venom on isolated Purkinje fibers
32. Mechanism of triggered arrhythmias
33. Introduction
34. Afterdepolarizations and triggered activity
35. Extrastimulus-related shortening of the first postpacing interval in digitalis-induced ventricular tachycardia: Observations during programmed electrical stimulation in the conscious dog
36. Delayed afterdepolarizations in heart muscle: Mechanisms and relevance
37. Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibers
38. Transient depolarization and spontaneous fluctuations in isolated single cells from guinea pig ventricles. Calcium-mediated membrane potential fluctuations
39. Triggered activity in the heart: Cellular mechanisms of early afterdepolarizations
40. Role of calcium ions in transient inward current and afterdepolarizations induced by strophanthidin in cardiac Purkinje fibers
41. Lonic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibers
42. Voltage-clamp studies of transient inward current and mechanical oscillations induced by ouabain in ferret papillary muscle
43. Fluctuation in membrane current driven by intracellular calcium in cardiac Purkinje fibers
44. Effects of sodium substitutes on transient inward current and tension in guinea-pig and ferret papillary muscle
45. + -ATPase
46. Effect of strophanthidin or intracellular Na ion activity and twitch tension in constantly driven canine cardiac Purkinje fibers
47. Relation between intracellular sodium and twitch tension in sheep cardiac Purkinje strands exposed to cardiac glycosides
48. Effects of bufadienolides and some kinds of cardiotonics on guinea pig hearts
49. Chronic blood pressure effects of bufalin, a sodium-potassium ATP-ase in hibitor, in rats
50. Toad toxicity
51. Digoxin-like immunoreactivity in Chinese medicine
52. Metabolism and disposition of Kyushin, a drug containing senso (Ch'an Su)
53. Determination of resibufogenin and cinobufagin in heart-protecting musk pill by HPLC
54. Neutralization of cardiac toxins oleandrin, oleandrigenin, bufalin, and cinobufotalin by digibind: Monitoring the effect by measuring free digitoxin concentrations
55. Efficacy of Digoxin specific Fab fragments (Digiband) in the treatment of toad venom poisoning