Metabolism and disposition of kyushin, a drug containing senso (ch'an su)

American Journal of Chinese Medicine

Volumn 24, Issue 3-4, 1996, Pages 289-303

  Hirai, Yasuharu Shimizu Née ^a   Morishita, Shin Ichi ^a  

^a Kyushin Pharmaceutical Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUFADIENOLIDE DERIVATIVE; BUFALIN; BUFOGENIN; CARDIOTONIC AGENT; CINOBUFAGIN;

ARTICLE; CHINESE MEDICINE; HUMAN; MALE; METABOLISM;

BUFANOLIDES; CARDIOTONIC AGENTS; HUMANS; MALE; MEDICINE, CHINESE TRADITIONAL;

EID: 0030339113     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/s0192415x96000359     Document Type: Article

References (30)

1. Aoki, K., M. Aoki, Y. Hirai and Y. Kuroiwa. Enzyme immunoassay for cinobufagin. Chemical Pharmaceutical Bulletin 34: 1184-1188, 1986.
2. Endo, T., S. Kano, N. Sakai and K. Katabami. Pharmacokinetics of Kyushin a drug containing toad venom, in healthy volunteers. Tokyoikadaigaku Zassi 50: 569-576, 1992 (Abstract in English).
3. Endo, Y. and K. Miyai. Assay systems (B/F separation, translated by author), In: Kousomenekisokuteihou, Tanpakusitu Kakusan Kouso (Suppl.) 31: edited by T. Kitagawa, T. Nambara and A. Tsuji. Tokyo: Kyoritsu Shuppan, 1987, pp. 13-26 (in Japanese).
4. Gsell, L. and C.H. Tamm. Magnetische protoneresonanz-spektroskopie der bufadienolide (steroidartigen krötengfte). Helvetica Chimica Acta 52: 551-568, 1969 (Abstract in English).
5. Hirai, Y., S. Toma, M. Shoji, Y. Oguni, C. Sugimoto, S. Morishita and C. Ito. Enzyme immunoassay forbufalin. The Japanese Journal of 'Pharmacology 55: (Suppl.) 308p, 1991.
6. Hosoda, H., Y. Sakai, H. Yoshida, S. Miyairi, K. Ishu and T. Nambara. The preparation of steroid N-hydroxysuccinimide esters and their reactivities with bovine serum albumin. Chemical Pharmaceutical Bulletin 27: 742-746, 1979a.
7. Hosoda, H., Y. Sakai, H. Yoshida, H. and T. Nambara. Enzyme labeling steroids by the activated ester method. Chemical Pharmaceutical Bulletin 27: 2147-2150, 1979b.
8. Ishibashi, M. and T. Motoya. Metabolism and disposition of drugs (7) (translated by author). Yakkyoku 38: 1061-1068, 1987 a (in Japanese).
9. Ishibashi, M. and T. Motoya. Metabolism and disposition of drugs (8) (translated by author). Yakkyoku 38: 1197-1205, 1987b (in Japanese).
10. Ishikawa, E. Method for enzyme labeling (translated by author). In: Kousomenekisokuteilwit 3rd ed., edited by E. Ishikawa, T. Kawai and K. Miyai. Tokyo: Igakushoin, 1987a, pp. 84-86 (in Japanese).
11. Ishikawa, E. Method for enzyme assay (translated by author). In: Koitsomenekisokuteilwu 3rd ed, edited by E. Ishikawa, T. Kawai and K. Miyai. Tokyo: Igakushoin, 1987b, pp. 57-58 (in Japanese).
12. Kawashima, K. and S. Takahashi. A clinical study of resibufogenin. Shinyaku To Rinsho 13: 1-8, 1964 (in Japanese).
13. Kominami, G., H. Matsumoto, R. Nishimura, T. Yamaguchi, R. Nonaka, K. Sugeno, K. Hirai and M. Kono. Combined high-performance liquid chromatography and enzyme immunoassay for active metabolites of a sleep inducer (rilmazafore) a ring-opened derivative of benzodiazepines, in human plasma. Journal of Chromatography 417:216-222, 1987.
14. Komatsu, M. and T. Okano. Separation of bufo-steroids by eluting dry column chromatography on silica gel. Yakugakit Zassi 87: 712-718, 1967 (in Japanese).
15. Lowry, O. H., N. J. Rosebrough, A. L. Fan and R. J. Randall. Protein measurement with the Polin phenol reagent. 77i
16. Morishita, S. T. Saito, Y. Mishima, A. Mizutani, Y. Hirai and M. Kawakami. Pharmacological studies of Senso (Ch'an Su) containing drugs. Folia Pliarmacol. Japon. 87: 361-378, 1986 (Abstract in English).
17. Morishita, S., M. Shoji, Y. Oguni, C. Ito, K. Noguchi and M. Sakanashi. Effects of Kyushin, a drug containing toad venom, on experimental congestive heart failure in rabbits. Am J Chin Med. 20: 83-89, 1992a.
18. Morishita, S., M. Shoji, Y. Oguni, C. Ito, M. Higuchi and M. Sakanashi. Pharmacological actions of Kyushin, a drug containing toad venom, on experimental congestive heart failure in rabbits. Am J Chin Med. 20: 245-256, 1992b.
19. Morishita, S., C. Sugimoto, M. Shoji, Y. Hirai, Y. Oguni, C. Ito, M. Higuchi and M. Sakanashi. Pharmacological actions of Kyushin, a drug containing toad venom (3): Effects on experimentally induced arrhythmia. Am J Chin Med. 21: 139-149, 1993.
20. Pettit, G. R. and Y. Kamano. Bufadienolides 21 : Synthesis of cinobufagin from bufotalin. Journal of Organic Chemistry, 37: 4040-4044, 1972.
21. Sakanashi, M., K. Noguchi, T. Chibana, Y. Ojiri and M. Shoji. Effects of intraduodenal administration of Kyushin, a Senso (toad venom)-containing drug, on systemic hemodynamics, cardiac function and myocardial oxygen consumption in anesthetized dogs. Am J Chin Med. 21:7-16, 1993.
22. Shoji, M., Y. Oguni, H. Sato, S. Morishita, C. Ito, M. Higuchi and M. Sakanashi. Pharmacological actions of Kyushin, a drug containing toad venom (2): Effects on urinary volume and electrolyte excretion. Am J Chin Med. 21: 17-31, 1993.
23. Suga, T. Chemistry and pharmacology of Ch'an Su (Senso) (translated by author). Taisya 10:762-774, 1973 (in Japanese).
24. Takada, K. Pharmacokinetics of drugs by two-compartment model (translated by author). In: Seibutsuyakitzaigakujikkenhoit, edited by T. Mochida and R. Arita. Tokyo: Nankoudo, 1984, pp. 147-155 (in Japanese).
25. Toma, S., S. Morishita, K. Kuronuma, Y. Mishima, Y. Hirai and M. Kawakami. Metabolism and pharmacokinetics of cinobufagin. Xenobiotica 17: 1195-1202, 1987.
26. Toma, S., Y. Hirai, C. Sugimoto, M. Shoji, Y. Oguni, S. Morishita, C. Ito and M. Horie. Pharmacokinetics of bufalin in rats. Yakugaku Zassi 111: 676-686, 199 la (Abstract in English).
27. Toma, S., Y. Hirai, C. Sugimoto, M. Shoji, Y. Oguni, S. Morishita, C. Ito and M. Horie. Metabolism and disposition of bufalin and cinobufagin, constituents of Ch'an Su (Senso). Yakugahi Zassi 111, 687-694, 1991b (Abstract in English).
28. Tsuji, A. and M. Maeda. Detection method for immunoassay (translated by author). In: Koitsomenekisokuteihou, Tanpakusitu Kakusan Kouso (Suppl.) 31: edited by T. Kitagawa, T. Nambara and A. Tsuji. Tokyo: Kyoritsu shuppan, 1987, pp. 51-63 (in Japanese).
29. Zang, L. S., K. Aoki, T. Yoshida and Y. Kuroiwa. Simultaneous determinations of cinobufagin and its metabolites by reverse-phase high performance liquid chromatography. Journal of Liquid Chromatography 13: 3515-3530, 1990.
30. Zang, L. S., T. Yoshida, K, Aoki and Y. Kuroiwa. Metabolism of cinobufagin in rat liver microsomes. Drug Metabolism and Disposition 19:917-919, 1991.