Genetic susceptibility to multiple sclerosis: Detection of polymorphic nucleotides and an intron in the 3′ untranslated region of the major histocompatibility complex class II transactivator gene

Human Immunology

Volumn 62, Issue 4, 2001, Pages 371-377

  Rasmussen, H B ^a   Kelly, M A ^b   Clausen, J ^a  

^a ROSKILDE UNIVERSITY   (Denmark)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

3 untranslated exon; Class II transactivator; Genetic variation; Multiple sclerosis

Indexed keywords

DNA FRAGMENT; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; INTRON; MONONUCLEAR CELL; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 0035045191     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(01)00215-4     Document Type: Article

References (18)

1. The genetic epidemiology of multiple sclerosis
2. Multiple sclerosis: Relevance of class I and class II MHC-expressing cells to lesion development
3. Regulation of MHC class II genes: Lessons from a disease
4. Quantitative control of MHC class II expression by the transactivator CIITA
5. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)
6. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA
7. New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
8. Genetic susceptibility to multiple sclerosis in a Shanghai Chinese population. The role of the HLA class II genes
9. Screening of multiple DNA samples for detection of sequence changes
10. RNA splice junctions of different classes of eukaryotes: Sequence statistics and functional implications in gene expression
11. Analysis of CIITA encoding AIR-1 gene promoters in insulin-dependent diabetes mellitus and rheumatoid arthritis patients from the northeast of Italy: Absence of sequence variability
12. Identification of distinct regions of 5′ flanking DNA that mediate constitutive, IFN-gamma, STAT1, and TGF-beta-regulated expression of the class II transactivator gene
13. Diversity of cytoplasmic functions for the 3′ untranslated region of eukaryotic transcripts
14. A rule for termination-codon position within intron-containing genes: When nonsense affects RNA abundance
15. Nonsense-mediated mRNA decay in health and disease
16. Regulation of AUF1 expression via conserved alternatively spliced elements in the 3′ untranslated region
17. Several mRNAs with variable 3′ untranslated regions and different stability encode the human PR264/SC35 splicing factor