Comparative analysis of ras proto-oncogene mutations in selected mammalian tumors

Molecular Carcinogenesis

Volumn 30, Issue 4, 2001, Pages 190-198

  Watzinger, F ^a   Mayr, B ^a   Gamerith, R ^a   Vetter, C ^a  

^a ST ANNA CHILDREN S HOSPITAL   (Austria)

Author keywords

And human single strand conformation polymorphisms; Canine; Feline; Mutation analysis

Indexed keywords

DNA FRAGMENT;

ARTICLE; CARCINOGENESIS; CAT; CODON; CONTROLLED STUDY; DOG; EXON; GENE ACTIVATION; GENE AMPLIFICATION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; MELANOMA; NEOPLASM; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; PATHOGENESIS; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM;

ANIMALS; CATS; DNA PRIMERS; DNA, NEOPLASM; DOGS; EXONS; FEMALE; GENES, RAS; HUMANS; NEOPLASMS; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTO-ONCOGENE PROTEINS P21(RAS); SEQUENCE ANALYSIS, DNA; TUMOR CELLS, CULTURED;

EID: 0035041737     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.1027     Document Type: Article

References (57)

1. Ras in signal transduction
2. Ras and human tumors
3. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
4. K-ras codon 12 point mutations occur very frequently in pancreatic adenomas
5. K-ras mutations in colorectal cancer: Relations to patient age, sex and tumour location
6. Ras oncogene activation in benign and malignant colorectal tumors
7. Ras oncogenes: Their role in neoplasia
8. Multiple point mutation of N-ras and K-ras oncogenes in myelodysplastic syndrome and acute myelogenous leukemia
9. N-ras gene mutations in acute myeloid leukemia: Accurate detection by solid-phase mini-sequencing
10. Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia
11. Activated ras genes in human seminoma: Evidence for tumor heterogeneity
12. K-ras oncogene codon 12 point mutations in testicular cancer
13. Oncogene activation in malignant transformation: A study of H- ras in human breast cancer
14. Incidence of activating ras oncogene mutations associated with primary and metastatic human breast cancer
15. Incidence of ras gene mutations in neuroblastomas
16. Activated N-ras oncogenes in human neuroblastoma
17. Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene
18. Ras activation in experimental carcinogenesis
19. K-ras activation in non-small cell lung cancer in the dog
20. p53, erbB-2 and K-ras gene alterations are rare in spontaneous and plutonium-239-induced canine lung neoplasia
21. Rapid detection of K-ras gene mutations in canine lung cancer using single-strand conformational polymorphism analysis
22. The molecular progression of plutonium-239-induced rat lung carcinogenesis: Ki-ras expression and activation
23. High frequency of codon 61 K-fas A → T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1, 3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1, 3-butadiene
24. Prognostic value of loss of heterozygosity and KRAS2 mutations in lung adenocarcinoma
25. Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer
26. Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer
27. Frequency of ras mutations in liver neoplasms from B6C3F1 mice exposed to tetrafluoroethylene for two years
28. Detection and identification of activated oncogenes in spontaneously occurring benign and malignant hepatocellular tumors of the B6C3F1 mouse
29. Ras gene analysis in mammary tumors of dogs by means of PCR-SSCP and direct genomic analysis
30. Cytogenetic alterations in eight mammary tumors and tumor-suppressor gene p53 mutation in one mammary tumor from dogs
31. c-N-ras is activated infrequently in canine malignant lymphoma
32. Kinetics of chimerism during the early post-transplant period in pediatric patients with malignant and non-malignant hematologic disorders: Implications for timely detection of engraftment, graft failure and rejection
33. Prevention of product carry-over by single tube two round (ST-2R) PCR: Application to BCR-ABL analysis in chronic myelogenous leukemia
34. High sequence similarity within ras exons 1 and 2 in different mammalian species and phylogenetic divergence of the ras gene family
35. Absence of N-ras mutations in myeloid and lymphoid blast crisis of chronic myeloid leukemia
36. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
37. Ras genes
38. Detection of transforming genes by transfection of primary soft tissue tumors
39. Genomic organization of the canine p53 gene and its mutational status in canine mammary neoplasia
40. Single somatic ras gene point mutation in soft tissue malignant fibrous histiocytomas
41. H-ras and K-ras gene mutations in primary human soft tissue sarcoma: Concomitant mutations of the ras genes
42. Malignant fibrous histiocytomas and H-ras-1 oncogene point mutations
43. H-ras and K-ras mutations in soft tissue sarcoma: Comparative studies of sarcomas from Korean and American patients
44. Oncogene activation in human benign tumors of the skin (keratoa-canthomas): Is H-RAS involved in differentiation as well as proliferation
45. Ras gene mutation and amplification in human nonmelanoma skin cancers
46. Codon 12 Harvey-ras mutations are rare events in non-melanoma human skin cancer
47. Low incidence of Ha-ras oncogene mutations in human epidermal tumors
48. H-ras-1 gene mutations in basal cell carcinoma: Automated direct sequencing of clinical specimens
49. N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin
50. Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma
51. Mutation analysis of the N-ras proto-oncogene in active and remission phase of human acute leukemias
52. Analysis of ras gene mutations and methylation state in human leukemias
53. N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis
54. The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing
55. Analysis of RAS oncogene mutations in human lymphoid malignancies