메뉴 건너뛰기




Volumn 20, Issue 4, 1999, Pages 657-662

High frequency of codon 61 K-ras A→T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BUTADIENE; CARCINOGEN; CHLOROPRENE; ISOPRENE; RAS PROTEIN;

EID: 0032994402     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.4.657     Document Type: Article
Times cited : (47)

References (49)
  • 1
    • 33847257651 scopus 로고    scopus 로고
    • Toxicology and carcinogenesis studies of chloroprene (CAS no. 126-99-8) in F344/N rats and B6C3F1 mice (inhalation studies)
    • NIH Publication no. 96-3957. NIEHS, Research Triangle Park, NC
    • National Toxicology Program (1996) Toxicology and carcinogenesis studies of chloroprene (CAS no. 126-99-8) in F344/N rats and B6C3F1 mice (inhalation studies). NTP Technical Report 467, NIH Publication no. 96-3957. NIEHS, Research Triangle Park, NC.
    • (1996) NTP Technical Report 467
  • 2
    • 0028032364 scopus 로고
    • Isoprene, an endogenous hydrocarbon and industrial chemical, induces multiple organ neoplasia in rodents after 26 weeks of inhalation exposure
    • Melnick, R.L., Sills, R.C., Roycroft, J.H., Chou, B.J., Ragan, H.A. and Miller, R.A. (1994) Isoprene, an endogenous hydrocarbon and industrial chemical, induces multiple organ neoplasia in rodents after 26 weeks of inhalation exposure. Cancer Res., 54, 5333-5339.
    • (1994) Cancer Res. , vol.54 , pp. 5333-5339
    • Melnick, R.L.1    Sills, R.C.2    Roycroft, J.H.3    Chou, B.J.4    Ragan, H.A.5    Miller, R.A.6
  • 3
    • 0025126209 scopus 로고
    • Inhalation toxicology of isoprene in F344 rats and B6C3F1 mice following two-week exposures
    • Melnick, R.L., Roycroft, J.H., Chou, B.J., Ragan, H.A. and Miller, R.A. (1990) Inhalation toxicology of isoprene in F344 rats and B6C3F1 mice following two-week exposures. Environ. Health Perspect., 86, 93-98.
    • (1990) Environ. Health Perspect. , vol.86 , pp. 93-98
    • Melnick, R.L.1    Roycroft, J.H.2    Chou, B.J.3    Ragan, H.A.4    Miller, R.A.5
  • 4
    • 0023262639 scopus 로고
    • Inhalation toxicity studies with 1,3-butadiene. Two-year toxicity/carcinogenicity studies in rats
    • Owen, P.E., Glaister, J.R., Graunt, I.F. and Pullinger, D.H. (1987) Inhalation toxicity studies with 1,3-butadiene. Two-year toxicity/carcinogenicity studies in rats. Am. Ind. Hyg. Assoc. J., 48, 407-413.
    • (1987) Am. Ind. Hyg. Assoc. J. , vol.48 , pp. 407-413
    • Owen, P.E.1    Glaister, J.R.2    Graunt, I.F.3    Pullinger, D.H.4
  • 5
    • 0004875241 scopus 로고
    • Chloroprene and Polychloroprene, Some Monomers, Plastics and Synthetic Elastomers and Acrolein
    • IARC, Lyon.
    • IARC (1987) Chloroprene and Polychloroprene, Some Monomers, Plastics and Synthetic Elastomers and Acrolein. IARC Monographs vol. 19, IARC, Lyon. pp. 131-156.
    • (1987) IARC Monographs , vol.19 , pp. 131-156
  • 8
    • 0003827210 scopus 로고
    • unpublished provisional data as of July 1, 1990. NIOSH, Cincinnati, OH
    • NIOSH (1990) National occupational exposure survey (1981 to 1983), unpublished provisional data as of July 1, 1990. NIOSH, Cincinnati, OH.
    • (1990) National Occupational Exposure Survey (1981 to 1983)
  • 9
    • 0344817401 scopus 로고
    • The occurrence of lung cancer among people working with chloroprene
    • Khachatrian, E.A. (1972) The occurrence of lung cancer among people working with chloroprene. Vopr. Onkol., 18, 585.
    • (1972) Vopr. Onkol. , vol.18 , pp. 585
    • Khachatrian, E.A.1
  • 10
    • 0024679239 scopus 로고
    • Epidemiologic study of cancer mortality among chloroprene workers
    • Shouqi, L., Quinan, D., Yuqing, L. and Yingfei, L. (1989) Epidemiologic study of cancer mortality among chloroprene workers. Biomed. Environ. Sci., 2, 141-149.
    • (1989) Biomed. Environ. Sci. , vol.2 , pp. 141-149
    • Shouqi, L.1    Quinan, D.2    Yuqing, L.3    Yingfei, L.4
  • 11
    • 0016821395 scopus 로고
    • Tissue-mediated mutagenicity of vinylidene chloride and 2-chlorobutadiene in Salmonella typhimurium
    • Bartsch, H., Malaveille, C., Montesano, R. and Tomatis, L. (1975) Tissue-mediated mutagenicity of vinylidene chloride and 2-chlorobutadiene in Salmonella typhimurium. Nature, 255, 641-643.
    • (1975) Nature , vol.255 , pp. 641-643
    • Bartsch, H.1    Malaveille, C.2    Montesano, R.3    Tomatis, L.4
  • 12
    • 0018345978 scopus 로고
    • Mutagenic and alkylating metabolites of haloethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues: Evidence for oxirane formation by P450-linked microsomal mono-oxygenases
    • Bartsch, H., Malaveille, C., Barbin, A. and Planche, G. (1979) Mutagenic and alkylating metabolites of haloethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues: evidence for oxirane formation by P450-linked microsomal mono-oxygenases. Arch. Toxicol., 41, 249-277.
    • (1979) Arch. Toxicol. , vol.41 , pp. 249-277
    • Bartsch, H.1    Malaveille, C.2    Barbin, A.3    Planche, G.4
  • 13
    • 0028047525 scopus 로고
    • Bacterial mutagenicity of 2-chloro-1,3-butadiene (chloroprene) caused by decomposition products
    • Westphal, G.A., Blaszkewicz, M., Leutbecher, M., Muller, A., Hallier, E. and Bolt, H.M. (1994) Bacterial mutagenicity of 2-chloro-1,3-butadiene (chloroprene) caused by decomposition products. Arch. Toxicol., 68, 79-84.
    • (1994) Arch. Toxicol. , vol.68 , pp. 79-84
    • Westphal, G.A.1    Blaszkewicz, M.2    Leutbecher, M.3    Muller, A.4    Hallier, E.5    Bolt, H.M.6
  • 14
    • 0017735450 scopus 로고
    • Aspects of the toxicology ot chloroprene: Immediate and long-term effects
    • Sanotskii, I.V. (1976) Aspects of the toxicology ot chloroprene: immediate and long-term effects. Environ. Health Perspect., 17, 85-93.
    • (1976) Environ. Health Perspect. , vol.17 , pp. 85-93
    • Sanotskii, I.V.1
  • 16
    • 0025101906 scopus 로고
    • Results of NTP-sponsored mouse cytogenic studies on 1,3-butadiene, isoprene and chloroprene
    • Shelby, M.D. (1990) Results of NTP-sponsored mouse cytogenic studies on 1,3-butadiene, isoprene and chloroprene. Environ. Health Perspect., 86, 71-73.
    • (1990) Environ. Health Perspect. , vol.86 , pp. 71-73
    • Shelby, M.D.1
  • 17
    • 0025048644 scopus 로고
    • Carcinogenicity of 1,3-butadiene in C57BL/6×C3HF1 mice at low exposure concentrations
    • Melnick, R.L., Huff, J., Chou, B.J. and Miller, R.A. (1990) Carcinogenicity of 1,3-butadiene in C57BL/6×C3HF1 mice at low exposure concentrations. Cancer Res., 50, 6592-6599.
    • (1990) Cancer Res. , vol.50 , pp. 6592-6599
    • Melnick, R.L.1    Huff, J.2    Chou, B.J.3    Miller, R.A.4
  • 19
    • 0026096577 scopus 로고
    • Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse
    • Devereux, T.R., Anderson, M.W. and Belinsky, S.A. (1991) Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse. Carcinogenesis, 12, 299-303.
    • (1991) Carcinogenesis , vol.12 , pp. 299-303
    • Devereux, T.R.1    Anderson, M.W.2    Belinsky, S.A.3
  • 21
    • 0023580015 scopus 로고
    • Cellular and molecular mechanisms of multistep carcinogenesis: Relevance to carcinogen risk assessment
    • Barrett, J.C. and Wiseman, R.W. (1987) Cellular and molecular mechanisms of multistep carcinogenesis: relevance to carcinogen risk assessment. Environ. Health Perspect., 76, 65-70.
    • (1987) Environ. Health Perspect. , vol.76 , pp. 65-70
    • Barrett, J.C.1    Wiseman, R.W.2
  • 22
    • 0029938649 scopus 로고    scopus 로고
    • The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: Perspectives, prospects and problems
    • Loechler, E.L. (1996) The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: perspectives, prospects and problems. Carcinogenesis, 17, 895-902.
    • (1996) Carcinogenesis , vol.17 , pp. 895-902
    • Loechler, E.L.1
  • 23
    • 0026658105 scopus 로고
    • Analysis of point mutations in murine c-Ha-ras of skin tumors initiated with dibenz[a,j]anthracene and derivatives
    • Gill, R.D., Beltran, L., Nettikumara, A.N., Harvery, R.G., Koostra, A. and DiGiovanni, J. (1992) Analysis of point mutations in murine c-Ha-ras of skin tumors initiated with dibenz[a,j]anthracene and derivatives. Mol. Carcinogen., 6, 53-59.
    • (1992) Mol. Carcinogen. , vol.6 , pp. 53-59
    • Gill, R.D.1    Beltran, L.2    Nettikumara, A.N.3    Harvery, R.G.4    Koostra, A.5    DiGiovanni, J.6
  • 24
    • 0029665674 scopus 로고    scopus 로고
    • Targeted A→T and G→T mutations induced by site-specific deoxyadenosine and deoxyguanosine adducts, respectively, from the (+)-anti-diol epoxide of dibenz|a,janthracene in M13mp7L2
    • Min, Z., Gill, R.D., Cortez, C., Harvey, R.G., Loechler, E.L. and DiGiovanni, J. (1996) Targeted A→T and G→T mutations induced by site-specific deoxyadenosine and deoxyguanosine adducts, respectively, from the (+)-anti-diol epoxide of dibenz|a,j]anthracene in M13mp7L2. Biochemistry, 35, 4128-4138.
    • (1996) Biochemistry , vol.35 , pp. 4128-4138
    • Min, Z.1    Gill, R.D.2    Cortez, C.3    Harvey, R.G.4    Loechler, E.L.5    DiGiovanni, J.6
  • 25
    • 0028043929 scopus 로고
    • Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors
    • Goodrow, T.L., Nichols, W.W., Storer, R.D., Anderson, M.W. and Maronpot, R.R. (1994) Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors. Carcinogenesis, 15, 2665-2667.
    • (1994) Carcinogenesis , vol.15 , pp. 2665-2667
    • Goodrow, T.L.1    Nichols, W.W.2    Storer, R.D.3    Anderson, M.W.4    Maronpot, R.R.5
  • 26
    • 0031408925 scopus 로고    scopus 로고
    • Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks
    • Hong, H.L., Devereux, T.R., Melnick, R.L., Eldridge, S.R., Greenwell, A., Haseman, J., Boorman, G.A. and Sills, R.C. (1997) Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks. Carcinogenesis, 18, 783-789.
    • (1997) Carcinogenesis , vol.18 , pp. 783-789
    • Hong, H.L.1    Devereux, T.R.2    Melnick, R.L.3    Eldridge, S.R.4    Greenwell, A.5    Haseman, J.6    Boorman, G.A.7    Sills, R.C.8
  • 27
    • 0021338990 scopus 로고
    • The reaction of 3,4-epoxy-1-butene with deoxyguanosine and DNA in vitro: Synthesis and characterization of the main adducts
    • Citti, L., Gervasi, P.G., Turchi, G., Bellucci, G. and Bianchini, R. (1984) The reaction of 3,4-epoxy-1-butene with deoxyguanosine and DNA in vitro: synthesis and characterization of the main adducts. Carcinogenesis, 5, 47-52.
    • (1984) Carcinogenesis , vol.5 , pp. 47-52
    • Citti, L.1    Gervasi, P.G.2    Turchi, G.3    Bellucci, G.4    Bianchini, R.5
  • 29
    • 0010022316 scopus 로고
    • Neoplasms of the integumentary system and Harderian gland
    • Foster, H.L., Small, J.D. and Fox, J.G. (eds) Academic Press, New York, NY
    • Holland, J.M. and Fry, R.J. (1982) Neoplasms of the integumentary system and Harderian gland. In Foster, H.L., Small, J.D. and Fox, J.G. (eds) The Mouse in Biomedical Research, vol. IV. Academic Press, New York, NY, pp. 513-528.
    • (1982) The Mouse in Biomedical Research , vol.4 , pp. 513-528
    • Holland, J.M.1    Fry, R.J.2
  • 30
    • 0025938503 scopus 로고
    • Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents
    • Huff, J., Cirvello, J., Haseman, J. and Bucher, J. (1991) Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents. Environ. Health Perspect., 93, 247-270.
    • (1991) Environ. Health Perspect. , vol.93 , pp. 247-270
    • Huff, J.1    Cirvello, J.2    Haseman, J.3    Bucher, J.4
  • 31
    • 85010439719 scopus 로고
    • A procedure for isolation of deoxyribonucleic acid from microorganisms
    • Marmur, J. (1961) A procedure for isolation of deoxyribonucleic acid from microorganisms. J. Mol. Biol., 3, 208-218.
    • (1961) J. Mol. Biol. , vol.3 , pp. 208-218
    • Marmur, J.1
  • 32
    • 0029039660 scopus 로고
    • Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months
    • Sills, R.C., Hong, H.L., Greenwell, A., Herbert, R.A., Boorman, G.A. and Devereux, T.R. (1995) Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months. Carcinogenesis, 16, 1623-1628.
    • (1995) Carcinogenesis , vol.16 , pp. 1623-1628
    • Sills, R.C.1    Hong, H.L.2    Greenwell, A.3    Herbert, R.A.4    Boorman, G.A.5    Devereux, T.R.6
  • 33
    • 0002538655 scopus 로고
    • Sample preparation from paraffin-embedded tissues
    • Innis, M.A., Gelfand, D.H., Sninsky, J.J. and White, T.J. (eds) Academic Press, San Diego, CA
    • Wright, D.K. and Manos, M.M. (1990) Sample preparation from paraffin-embedded tissues. In Innis, M.A., Gelfand, D.H., Sninsky, J.J. and White, T.J. (eds) PCR Protocols: A Guide to Methods and Applications. Academic Press, San Diego, CA, pp. 153-158.
    • (1990) PCR Protocols: A Guide to Methods and Applications , pp. 153-158
    • Wright, D.K.1    Manos, M.M.2
  • 35
    • 0027314749 scopus 로고
    • Ras proto-oncogene activation in liver and lung tumors from B6C3F1 mice exposed chronically to methylene chloride
    • Devereux, T.R., Foley, J.F. Maronpot, R.R., Kari, F. and Anderson, M.W. (1993) ras proto-oncogene activation in liver and lung tumors from B6C3F1 mice exposed chronically to methylene chloride. Carcinogenesis, 14, 795-801.
    • (1993) Carcinogenesis , vol.14 , pp. 795-801
    • Devereux, T.R.1    Foley, J.F.2    Maronpot, R.R.3    Kari, F.4    Anderson, M.W.5
  • 36
    • 0025092216 scopus 로고
    • Specific patterns of oncogene activation in transplacentally induced tumors
    • Sukumuar, S. and Barbacid, M. (1990) Specific patterns of oncogene activation in transplacentally induced tumors. Proc. Natl Acad. Sci. USA, 87, 718-722.
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 718-722
    • Sukumuar, S.1    Barbacid, M.2
  • 37
    • 0027320778 scopus 로고
    • 'Cold SSCP': A simple, rapid and non-radioactive method for optimized single-strand conformation polymorphism analyses
    • Hongyo, T., Buzard, G.S., Calvert, R.J. and Weghorst, C.M. (1993) 'Cold SSCP': a simple, rapid and non-radioactive method for optimized single-strand conformation polymorphism analyses. Nucleic Acids Res., 21, 3637-3642.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 3637-3642
    • Hongyo, T.1    Buzard, G.S.2    Calvert, R.J.3    Weghorst, C.M.4
  • 38
    • 0024592908 scopus 로고
    • Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (A S52) cells
    • Tindall, K. and Stankowski, L. (1988) Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (A S52) cells. Mutat. Res., 220, 241-253.
    • (1988) Mutat. Res. , vol.220 , pp. 241-253
    • Tindall, K.1    Stankowski, L.2
  • 39
    • 0025372609 scopus 로고
    • Activation of K-ras by codon 13 mutations in C57BL/6×C3H F1 mouse tumors induced by exposure to 1,3-butadiene
    • Goodrow, T. Reynolds, S., Maronpot, R. and Anderson, M. (1990) Activation of K-ras by codon 13 mutations in C57BL/6×C3H F1 mouse tumors induced by exposure to 1,3-butadiene. Cancer Res., 50, 4818-4823.
    • (1990) Cancer Res. , vol.50 , pp. 4818-4823
    • Goodrow, T.1    Reynolds, S.2    Maronpot, R.3    Anderson, M.4
  • 40
    • 0030961941 scopus 로고    scopus 로고
    • Analysis of hprt mutations occurring in human TK6 lymphoblastoid cells following exposure to 1,2,3,4-diepoxybutane
    • Steen, A., Meyer, K.G. and Recio, L. (1997) Analysis of hprt mutations occurring in human TK6 lymphoblastoid cells following exposure to 1,2,3,4-diepoxybutane. Mutagenesis, 12, 61-67.
    • (1997) Mutagenesis , vol.12 , pp. 61-67
    • Steen, A.1    Meyer, K.G.2    Recio, L.3
  • 41
    • 0028026138 scopus 로고
    • Mutagenicity of butadiene and its epoxide metabolites: II. Mutational spectra of butadiene 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from exposed B6C3F1 mice
    • Cochrane, J.E. and Skopek, T.R. (1994) Mutagenicity of butadiene and its epoxide metabolites: II. Mutational spectra of butadiene 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from exposed B6C3F1 mice. Carcinogenesis, 15, 719-723.
    • (1994) Carcinogenesis , vol.15 , pp. 719-723
    • Cochrane, J.E.1    Skopek, T.R.2
  • 42
    • 0028181694 scopus 로고
    • Molecular analysis of lacI mutants from bone marrow of B6C3F1 transgenic mice following inhalation exposure to 1,3-butadiene
    • Sisk, S.S., Pluta, L.J., Bond, J.A. and Recio, L. (1994) Molecular analysis of lacI mutants from bone marrow of B6C3F1 transgenic mice following inhalation exposure to 1,3-butadiene. Carcinogenesis, 15, 471-477.
    • (1994) Carcinogenesis , vol.15 , pp. 471-477
    • Sisk, S.S.1    Pluta, L.J.2    Bond, J.A.3    Recio, L.4
  • 43
    • 0025055769 scopus 로고
    • DNA polymerase action on bulky deoxyguanosine and deoxyadenosine adducts
    • Reardon, D.B., Bigger, C.A.H. and Dipple, A. (1990) DNA polymerase action on bulky deoxyguanosine and deoxyadenosine adducts. Carcinogenesis, 11, 165-168.
    • (1990) Carcinogenesis , vol.11 , pp. 165-168
    • Reardon, D.B.1    Bigger, C.A.H.2    Dipple, A.3
  • 44
    • 0028785807 scopus 로고
    • Relating aromatic hydrocarbon-induced DNA adducts and c-Ha-ras mutations in mouse skin papillomas: The role of apurinic sites
    • Chakravarti, D., Pelling, J.C., Cavalieri, E.L. and Rogan, E.G. (1995) Relating aromatic hydrocarbon-induced DNA adducts and c-Ha-ras mutations in mouse skin papillomas: the role of apurinic sites. Proc. Natl Acad. Sci. USA, 92, 10422-10426.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 10422-10426
    • Chakravarti, D.1    Pelling, J.C.2    Cavalieri, E.L.3    Rogan, E.G.4
  • 45
    • 0027951237 scopus 로고
    • Mutagenicity of butadiene and its epoxide metabolites. I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts
    • Cochrane, J.E. and Skopek, T.R. (1994) Mutagenicity of butadiene and its epoxide metabolites. I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts. Carcinogenesis, 15, 713-717.
    • (1994) Carcinogenesis , vol.15 , pp. 713-717
    • Cochrane, J.E.1    Skopek, T.R.2
  • 46
    • 0021999773 scopus 로고
    • Mutagenicity and chemical reactivity of epoxidic intermediates of the isoprene metabolism and other structurally related compounds
    • Gervasi, P.G., Citti, L., Del Monte, M. Longo, V. and Benetti, D. (1985) Mutagenicity and chemical reactivity of epoxidic intermediates of the isoprene metabolism and other structurally related compounds. Mutat. Res., 156, 77-82.
    • (1985) Mutat. Res. , vol.156 , pp. 77-82
    • Gervasi, P.G.1    Citti, L.2    Del Monte, M.3    Longo, V.4    Benetti, D.5
  • 47
    • 0029616536 scopus 로고
    • Dose-response relationships for carcinogens
    • Swenberg, J.A., La, D.K., Scheller, N.A. and Wu, K. (1995) Dose-response relationships for carcinogens. Toxicol. Lett., 82/83, 751-756.
    • (1995) Toxicol. Lett. , vol.82-83 , pp. 751-756
    • Swenberg, J.A.1    La, D.K.2    Scheller, N.A.3    Wu, K.4
  • 48
    • 0031966274 scopus 로고    scopus 로고
    • The traditional toxicologic paradigm is correct: Dose influences mechanism
    • Goodman, J.I. (1998) The traditional toxicologic paradigm is correct: dose influences mechanism. Environ. Health Perspect., 106, 285-288.
    • (1998) Environ. Health Perspect. , vol.106 , pp. 285-288
    • Goodman, J.I.1
  • 49
    • 0026335731 scopus 로고
    • Dose-dependent differences in the profile of mutations induced by an ultimate carcinogen from benzo[a]pyrene
    • Wei, S.-J.C., Chang, R.L., Wong, C. et al. (1991) Dose-dependent differences in the profile of mutations induced by an ultimate carcinogen from benzo[a]pyrene. Proc. Natl Acad. Sci. USA, 88, 11227-11230.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 11227-11230
    • Wei, S.-J.C.1    Chang, R.L.2    Wong, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.