Assessment of the effect of 2-chloroadenosine in normal rat brain using spin-labeled MRI measurement of perfusion

Magnetic Resonance in Medicine

Volumn 45, Issue 5, 2001, Pages 924-929

  Kochanek, Patrick M ^a   Hendrich, Kristy S ^a   Robertson, Courtney L ^a   Williams, Donald S ^a   Melick, John A ^a   Ho, Chien ^a   Marion, Donald W ^b   Jackson, Edwin K ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine; Brain; Cerebral blood flow; Hyperemia; Purine

Indexed keywords

BLOOD; HEMODYNAMICS; IMAGE SEGMENTATION; RATS;

ADENOSINE; CEREBRAL BLOOD FLOW; DOSE RESPONSE RELATIONSHIPS; DOSE-DEPENDENT; HYPEREMIA; PURINE; REGION OF INTEREST; SPRAGUE-DAWLEY RATS;

BRAIN;

2 CHLOROADENOSINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; DOSE RESPONSE; DRUG DISTRIBUTION; DRUG POTENCY; IMAGING SYSTEM; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; RAT STRAIN; SPIN LABELING; VASODILATATION;

EID: 0035041099     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1123     Document Type: Article

References (22)

1. Release of adenosine from ischemic brain. Effect on cerebral vascular resistance and incorporation into cerebral adenine nucleotides
2. The effect of local infusion of adenosine and adenosine analogues on local cerebral blood flow
3. Regional cerebral blood flow after controlled cortical impact injury in rats
4. 2 reactivity after controlled cortical impact by perfusion magnetic resonance imaging using arterial spin labeling in rats
5. Early perfusion after controlled cortical impact in rats: Quantification by arterial spin-labeled MRI and the influence of spin-lattice relaxation time heterogeneity
6. Dissociation of adenosine levels from bioenergetic state in experimental brain trauma: Potential role in secondary injury
7. An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus
8. Adenosine and acute treatment of cerebral ischemia and stroke - "Put out more flags."
9. Therapeutic potential for adenosine receptor activation in ischemic brain injury
10. Perfusion imaging
11. Magnetic resonance imaging of perfusion using spin inversion of arterial water
12. Multi-slice MRI of rat brain perfusion during amphetamine stimulation using arterial spin labeling
13. Measurement of rat brain perfusion by NMR using spin labeling of arterial water: In vivo determination of the degree of spin labeling
14. Stimulate: A GUI based fMRI analysis software package
15. NMR measurement of perfusion using arterial spin labeling without saturation of macromolecular spins
16. Adenosine receptors of cerebral microvessels and choroid plexus
17. Role of adenosine and its receptors in the vasodilation induced in the cerebral cortex of the rat by systemic hypoxia
18. Effect of topical adenosine deaminase treatment on the functional hyperemic and hypoxic responses of cerebrocortical microcirculation
19. The protective effect of 2-chloroadenosine against the development of amygdala-kindled seizures
20. Adenosine receptors in the central nervous system: Relationship to the central actions of methylxanthines
21. Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes
22. A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice