Angiostatin gene therapy inhibits the growth of murine squamous cell carcinoma in vivo

Oral Oncology

Volumn 37, Issue 4, 2001, Pages 369-378

  Matsumoto, G ^a   Ohmi, Y ^a   Shindo, J ^a  

^a KANAGAWA DENTAL COLLEGE   (Japan)

Author keywords

Angiostatin; Gene therapy

Indexed keywords

ANGIOSTATIN; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL DESTRUCTION; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENE THERAPY; GENE TRANSFER; GENETIC CODE; IN VIVO STUDY; MOUSE; MOUTH CARCINOMA; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TUMOR GROWTH; TUMOR VASCULARIZATION; VASCULAR ENDOTHELIUM;

ANGIOSTATINS; ANIMALS; ANTIGENS, CD31; APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; DNA, COMPLEMENTARY; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; LYMPHOKINES; MICE; MICE, INBRED C3H; PEPTIDE FRAGMENTS; PLASMINOGEN; POLYMERASE CHAIN REACTION; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035040894     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1368-8375(00)00100-7     Document Type: Article

References (33)

1. Head and neck cancer
2. The implication of angiogenesis for the biology and therapy of cancer metastases
3. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
4. Angiogenesis in cancer, vascular, rhumatoid and other disease
5. Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma
6. Molecular and biological properties of the vascular endothelial cell growth factor family of proteins
7. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
8. A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1
9. Control of angiogenesis in fibroblasts by p53 regulation of Thrombospondin-1
10. p53 mutations in human head and neck cancer cell lines
11. p53 gene mutations in sequential oral epithelial dysplasias and squamous cell carcinomas
12. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis Lung Carcinoma
13. Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis Lung Carcinoma
14. Angiostatin-mediated suppression of cancer metastases by primary neoplasms engineered to produce glanulocyte/macrophage colony-stimulating factor
15. Monoclonal antibodies specific for endotherial cells of mouse blood vessels
16. Expression of angiostatin cDNA in murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases
17. Angiostatin gene transfer: Inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest
18. Viral vector-targeted gene therapy utilizing an angiostatin complementary DNA
19. Kringle domeins of human angiostatin
20. Vascular permeability factor (VPF, VEGF) in tumor biology
21. Up-regulation of vascular endothelial growth factor and its cobnate receptors in a rat glioma model of tumor angiogenesis
22. Angiostatin suppresses malignant glioma growth in vivo
23. Tumor induction of VEGF promoter activity in stromal cells
24. Vascular endothelial growth facto (VEGF) and its receptors
25. Identification of a new endothelial growth factor receptor tyrosine kinase
26. FLT4, a novel class III receptor tyrosine kinase in chromosome5q33-qter
27. The fibroblast growth factor family
28. Differential signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
29. Increased expression of vascular permeality factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas
30. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract
31. Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis
32. Ischemia-and cytokine induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
33. Endothelial progenitor cells as putative targets for angiostatin