(+)-p-([18F]fluorobenzyl)spirotrozamicol {(+)-[18F]spiro-FBT}: Synthesis and biological evaluation of a high-affinity ligand for the vesicular acetylcholine transporter (VAChT)

Nuclear Medicine and Biology

Volumn 26, Issue 2, 1999, Pages 189-192

  Efange, S M N ^a   Nader, M A ^b   Ehrenkaufer, R L E ^b   Khare, A B ^a   Smith, C R ^b   Morton, T E ^b   Mach, R H ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Acetylcholine; Synaptic vesicles; Transporter; Vesamicol analogue

Indexed keywords

[4 HYDROXY 1 (4 FLUOROBENZYL)PIPERIDIN 3 YL]SPIRO[1 INDENE 1,4' PIPERIDINE]; FLUORODEOXYGLUCOSE F 18; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG; VESICULAR ACETYLCHOLINE TRANSPORTER; 1' (4 HYDROXY 1 (4 FLUOROBENZYL)PIPERIDIN 3 YL)SPIRO(1H INDENE 1,4' PIPERIDINE); 1'-(4-HYDROXY-1-(4-FLUOROBENZYL)PIPERIDIN-3-YL)SPIRO(1H-INDENE-1,4'-PIPERIDINE); ACETYLCHOLINE; CARRIER PROTEIN; DIAGNOSTIC AGENT; FLUORINE; SLC18A3 PROTEIN, RAT; SPIRO COMPOUND; VESICULAR TRANSPORT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; DRUG SYNTHESIS; LIGAND BINDING; MEMBRANE BINDING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SYNAPSE VESICLE; TISSUE DISTRIBUTION; ANIMAL; BRAIN; CHEMICAL STRUCTURE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; EVALUATION; MACACA; MALE; METABOLISM; RADIOASSAY; SPRAGUE DAWLEY RAT; SYNTHESIS;

ACETYLCHOLINE; ANIMALS; BRAIN; CARRIER PROTEINS; EVALUATION STUDIES; FLUORINE RADIOISOTOPES; MACACA MULATTA; MALE; MEMBRANE TRANSPORT PROTEINS; MOLECULAR STRUCTURE; PIPERIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; SPIRO COMPOUNDS; SYNAPTIC VESICLES; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS; VESICULAR TRANSPORT PROTEINS;

EID: 0032587154     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(98)00090-0     Document Type: Article

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