Detection of invasion-related chromosomal changes in highly and weakly invasive melanoma cell clones by a modified comparative genomic hybridization approach

Melanoma Research

Volumn 11, Issue 2, 2001, Pages 105-115

  Gunther K ^a   Fleischer, A ^a   Buettner, R ^a   Bosserhoff, A K ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Boyden chamber; CGH; FISH; Invasion; Melanoma; Metastasis

Indexed keywords

ARTICLE; CANCER GROWTH; CANCER INVASION; CELL CLONE; CELL LINE; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DNA HYBRIDIZATION; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; MELANOMA CELL; PHENOTYPE; PRIORITY JOURNAL;

CELL LINE; CHROMOSOME ABERRATIONS; CHROMOSOME MAPPING; DISEASE PROGRESSION; DNA; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MELANOMA; NEOPLASM INVASIVENESS; NUCLEIC ACID HYBRIDIZATION; PHENOTYPE; TUMOR CELLS, CULTURED;

EID: 0035035211     PISSN: 09608931     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008390-200104000-00004     Document Type: Article

References (56)

1. Consistent karyotypic abnormalities in human malignant melanomas
2. Molecular markers of melanocytic tumor progression
3. Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression
4. Chromosomal allele loss in primary cutaneous melanoma is heterogeneous and correlates with proliferation
5. Allelic loss at the p73 locus (1p36.33) is infrequent in malignant melanoma
6. Loss of expression or mutations in the p73 tumour suppressor gene are not involved in the pathogenesis of malignant melanomas
7. The human leukocyte antigen TAP2 gene defines the centromeric limit of melanoma susceptibility on chromosome 6p
8. Isolation and characterization of genes associated with chromosome-6 mediated tumor suppression in human malignant melanoma
9. Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma
10. The putative melanoma tumor-suppressor gene on human chromosome 6q
11. Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6
12. Chromosome 10 allelic loss in malignant melanoma
13. Cytogenetics of melanocytic tumors
14. Possible involvement of the chromosome region 10q24-q26 in early stages of melanocytic neoplasia
15. The chromosome 10 monosomy common in human melanomas results from loss of two separate tumor suppressor loci
16. The PTEN tumour suppressor gene and malignant melanoma
17. Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines
18. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
19. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
20. Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression
21. Homozygous deletions within human chromosome band 9p21 in melanoma
22. Characterization of selected strongly and weakly invasive sublines of a primary human melanoma cell line and isolation of subtractive cDNA clones
23. In vitro modulation of human melanoma cell invasion and proliferation by all-trans-retinoic acid
24. Differences in genetic alterations between primary lobular and ductal breast cancers detected by comparative genomic hybridization
25. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors
26. Quality control of CGH: Impact of metaphase chromosomes and the dynamic range of hybridization
27. Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization
28. In situ hybridization as a tool to study numerical chromosome aberrations in solid bladder tumors
29. The application of comparative genomic hybridization and fluorescence in situ hybridization to the characterization of genotoxicity screening tester strains AHH-1 and MCL-5
30. Genetic alterations in primary breast cancers and their metastases: Direct comparison using modified comparative genomic hybridization
31. Comparative genomic hybridization analysis of chromosomal alterations induced by the development of resistance to thymidylate synthase inhibitors
32. Chromosomal aberrations associated with invasion in papillary superficial bladder cancer
33. Patterns of chromosomal alterations in metastasizing and nonmetastasizing primary head and neck carcinomas
34. Distinct patterns of chromosomal alterations in high- and low-grade head and neck squamous cell carcinomas
35. Genetic alterations in lobular breast cancer by comparative genomic hybridization
36. Comparative genomic hybridization reveals frequent gains of 20q, 8q, 11q, 12p, and 17q, and losses of 18q, 9p, and 15q in pancreatic cancer
37. Cytogenetic follow-up in a case with a primary cutaneous melanoma and five metastatic lesions
38. Cytogenetic findings in 20 melanomas
39. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
40. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
41. Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor
42. Loss of c-kit expression in cultured melanoma cells
43. KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells
44. Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis
45. Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential
46. Cytogenetic studies of human malignant melanoma cell lines
47. Increased chromosome 20 copy number detected by fluorescence in situ hybridization (FISH) in malignant melanoma
48. Molecular characterization of a novel amplicon at 1q21-q22 frequently observed in human sarcomas
49. Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization
50. Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas
51. The p97 antigen is mapped to the q24-qter region of chromosome 3; the same region as the transferrin receptor
52. Nonrandom chromosome changes in malignant melanoma
53. 10q deletions in metastatic cutaneous melanoma
54. Functional localization of a melanoma tumor suppressor gene to a small (< or = 2 Mb) region on 11q23
55. A malignant melanoma tumor suppressor on human chromosome 11
56. Allele loss on chromosome 11q and microsatellite instability in malignant melanoma