Absence of protease-resistant prion protein in the cerebrospinal fluid of Creutzfeldt-Jakob disease

Journal of Pathology

Volumn 194, Issue 1, 2001, Pages 9-14

  Wong, Boon Seng ^a   Green, Alison J E ^b   Li, Ruliang ^a   Xie, Zhiliang ^a   Pan, Tao ^a   Liu, Tong ^a   Chen, Shu G ^a   Gambetti, Pierluigi ^a   Sy, Man Sun ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Cerebrospinal fluid; Creutzfeldt Jakob disease; Epitope mapping; Prion; Proteinase K; Transmissible spongiform encephalopathy

Indexed keywords

ISOPROTEIN; PRION PROTEIN; PROTEINASE;

AGE; ARTICLE; BLOOD; CENTRAL NERVOUS SYSTEM; CEREBELLAR ATAXIA; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION FUNCTION; CREUTZFELDT JAKOB DISEASE; DEATH; DEMENTIA; DISEASE COURSE; DISEASE TRANSMISSION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR FLUID; HUMAN; HUMAN TISSUE; IMMUNOASSAY; MENTAL DISEASE; NEUROLOGIC DISEASE; PLASMA; PRION DISEASE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN VARIANT; SYMPTOM;

CREUTZFELDT-JAKOB SYNDROME; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASE K; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; HUMANS; PRIONS; PROTEIN CONFORMATION; PROTEIN ISOFORMS;

EID: 0035034926     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.872     Document Type: Article

References (24)

1. Prions
2. Diagnosis of new variant Creutzfeldt-Jakob disease
3. Evidence for a secretory form of the cellular prion protein
4. Prion protein biosynthesis in scrapie-infected and uninfected neuroblastoma cells
5. A soluble form of prion-related in human cerebrospinal fluid: Implications for prion-related encephalopathies
6. Pathology of cerebrospinal fluid and interstitial fluid of the CNS: Significance for Alzheimer disease, prion disorders and multiple sclerosis
7. Cerebrospinal fluid
8. Prion diseases blood and the immune system: Concerns and reality
9. Involvement of the immune system in TSE pathogenesis
10. Truncated forms of the human prion protein in normal brain and in prion diseases
11. Identification of an epitope in the C terminus of normal prion protein whose expression is modulated by binding events in the N terminus
12. Differential contribution of superoxide dismutase activity by prion protein in vivo
13. Prion protein expression in different species: Analysis with a panel of new mAbs
14. Increased S100beta in the cerebrospinal fluid of patients with frontotemporal dementia
15. A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform
16. Structure of the recombinant full-length hamster prion protein PrP(29-231): The N terminus is highly flexible
17. Eight prion strains have PrP(Sc) molecules with different conformations
18. Mapping the prion protein using recombinant antibodies
19. Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets
20. Human spongiform encephalopathy: The National Institutes of Health series of 300 cases of experimentally transmitted disease
21. Transmissible and genetic prion diseases share a common pathway of neurodegeneration
22. Protease-resistant prion protein produced in vitro lacks detectable infectivity
23. Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein
24. Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy