Mutation screening of the hepatocyte nuclear factor (HNF)-6 gene in Japanese subjects with diabetes mellitus

Diabetes Research and Clinical Practice

Volumn 52, Issue 3, 2001, Pages

  Zhu, Q ^a   Yamagata, K ^a   Tsukahara, Y ^a   Yang, Q ^a   Liu, W ^a   Hanafusa, T ^b   Miyagawa, J ^a   Matsuzawa, Y ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Genetics; HNF 6; MODY

Indexed keywords

TRANSCRIPTION FACTOR;

ADULT; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE PREDISPOSITION; DNA POLYMORPHISM; GENE MUTATION; GENETIC VARIABILITY; HUMAN; JAPAN; JUVENILE DIABETES MELLITUS; MAJOR CLINICAL STUDY; MUTATION;

ADOLESCENT; ADULT; AGE OF ONSET; ASIAN CONTINENTAL ANCESTRY GROUP; DIABETES MELLITUS, TYPE 2; FAMILY; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HEPATOCYTE NUCLEAR FACTOR 6; HOMEODOMAIN PROTEINS; HUMANS; JAPAN; MIDDLE AGED; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANS-ACTIVATORS; VARIATION (GENETICS);

EID: 0035033775     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(01)00222-4     Document Type: Article

References (13)

1. HNF-1, a member of a novel class of dimerizing homeodomain proteins
2. HNF1, a homeoprotein member of the hepatic transcription regulatory network
3. Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain
4. Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
5. Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)
6. Mutation in hepatocyte nuclear factor-1β gene (TCF2) associated with maturity-onset diabetes of the young
7. Identification of mutations in the hepatocyte nuclear factor-1α gene in Japanese subjects with early-onset NIDDM and functional analysis of the mutant proteins
8. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3
9. Loci on chromosome 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans
10. Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3α, 3β, 3γ and 6
11. Hepatocyte nuclear factor-6: associations between genetic variability and Type II diabetes and between genetic variability and estimates of insulin secretion
12. Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3β and mutation screening in Japanese subjects with MODY