β-amyloid: Friend or foe

Medical Hypotheses

Volumn 56, Issue 3, 2001, Pages 388-391

  Campbell, A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; COMPLEMENT; CYCLOOXYGENASE 2; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEOCHONDROITIN SULFATE;

AGING; ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; DEFENSE MECHANISM; HUMAN; IMMUNITY; INFLAMMATION; MENINX; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN PROCESSING; SENILE PLAQUE;

EID: 0035033516     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.2000.1212     Document Type: Article

References (40)

1. Aging-associated changes in human brain
2. Penetration of solutes, viruses, and cells across the blood-brain barrier
3. Brain aluminum in aging and Alzheimer's disease
4. Reactive microgliosis
5. Glial reaction in the hippocampal formation is highly concentrated with aging in human brain
6. Function and activation of NF-κB in the immune system
7. NF-κB and the innate immune response
8. An ancient system of host defense
9. Strong nuclear factor -κB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex
10. The involvement of amyloid associated proteins in the formation of β-protein filaments in Alzheimer's disease
11. Amyloid precursor protein protect neurons of transgenic mice against acute and chronic excitation injuries in vivo
12. The role of the amyloid protein precursor (APP) in Alzheimer's disease. Does the normal function of APP explain the topography of neurodegeneration?
13. Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice
14. Post-ischemic changes in the expression of Alzheimer's APP isoforms in rat cerebral cortex
15. Translation of the Alzheimer's amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences
16. β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
17. Uptake, degradation, release of fibrillar and soluble forms of Alzheimer's Amyloid β-peptide by microglial cells
18. 1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
19. Inhibition of Alzheimer's β-amyloid induced vasoactivity and proinflammatory response in microglia by cGMP-dependent mechanism
20. Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease
21. The molecular basis of amyloidosis
22. Beta-amyloid of Alzheimer's disease induces reactive gliosis that inhibits axonal outgrowth
23. Regional differences in reactive gliosis induced by substrate-bound β-amyloid
24. Amyloid peptides are toxic via a common oxidative mechanism
25. Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress
26. 2 forming NADPH oxidase in microglia, monocytes and neutrophils
27. Activation of microglial cells by β-amyloid protein interferon-γ
28. Beta (1-40) amyloid peptide injection into the nucleus basalis of rats induces microglia reaction and enhances cortical gamma-aminobutyric acid release in vivo
29. Perivascular astrocytes within Alzheimer's disease plaques
30. Interleukin-1β activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo Implications for Alzheimer's disease
31. Complement activation by β-amyloid in Alzheimer's disease
32. Complement activation by cross-linked truncated and chimeric full-length β-amyloid
33. The mouse C1q A-chain sequence alters beta-amyloid-induced complement activation
34. Cytokines associated with amyloid plaques in Alzheimer's disease brain stimulate human glial and neuronal cell cultures to secrete early complement proteins, but not C1-inhibitor
35. Synthesis of complement components C3 and factor B in human keratinocytes is differentially regulated by cytokines
36. Amyloid β peptide stimulates nitric oxide production in astrocytes through an NF-κB-dependent mechanism
37. Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation
38. Macrophage colony-stimulating factor augments β-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells
39. Prointlammatory profile of cytokine production by human monocytes and murine microglia stimulated with β-amyloid[25-35]
40. Amyloid β peptide potentiates cytokine secretion by interleukin-1β-activated human astrocytoma cells