Synthesis of complement components C3 and factor B in human keratinocytes is differentially regulated by cytokines

Journal of Investigative Dermatology

Volumn 114, Issue 1, 2000, Pages 78-82

  Pasch, Marcel C ^a   Van Den Bosch, Norbert H A ^a   Daha, Mohamed R ^b   Jan D, Bos ^a   Asghar, Syed S ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

C3; Complement; Cytokines; Enzyme linked immunosorbent assay; Factor B; Interferon ; Interleukin 6; Interleukin 1 ; Interleukin 2; Keratinocytes reverse transcription polymerase chain reaction; Transforming growth factor ; Tumor necrosis

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 6; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; KERATINOCYTE; LEUKOCYTE ACTIVATION; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN SYNTHESIS REGULATION; REGULATORY MECHANISM;

EID: 0034038006     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00841.x     Document Type: Article

References (24)

1. Asghar SS, Pasch MC: Complement as a promiscuous signal transduction device. Lab Invest 78:1203-1225, 1998
2. Basset-Seguin N, Wright Caughman S, Yancey K: A-431 cells and human keratinocytes synthesize and secrete the third component of complement. J Invest Dermatol 95:621-625, 1990
3. Brooimans RA, van der Ark AAJ, Es LA, Daha MR: Differential regulation of complement factor H and C3 production in human umbilical vein endothelial cells by IFN-gamma and IL-1. J Immunol 144:3855-3840, 1990
4. van den Dobbelsteen MEA, Verhasselt V, Kaashoek JGJ, et al: Regulation of C3 and factor H synthesis of human glomerular mesangial cells by IL-1 and interferon-gamma. Clin Exp Immunol 95:173-180, 1994
5. Gordon DL, Avery VM, Adrian DL, Sadlon TA: Detection of complement protein mRNA in human astrocytes by the polymerase chain reaction. J Neurosci Methods 45:191-197, 1992
6. Hogasen AK, Wurzner R, Abrahamsen TG, Dierich MP: Human polymorphonuclear leukocytes store large amounts of terminal complement components C7 and C6, which may be released on stimulation. J Immunol 154:4734-4740, 1995
7. 2/IL-6 genes in human fibroblasts. J Immunol 142:3862-3867, 1989
8. Katz Y, Cole FS, Strunk RC: Synergism between g interferon and lipopolysaccharide for synthesis of factor B, but not C2, in human fibroblasts. J Exp Med 167:1-14, 1988
9. Katz Y, Cole FS, Strunk RC: Interleukin 6 stimulates synthesis of complement proteins factor B and C3 in human skin fibroblasts. Eur J Immunol 19:983-988, 1989
10. Lappin D, Hamilton LM, Morrison L, Aref M, Whaly K: Synthesis of complement components (C3, C2, B and C1-inhibitor) and lysozyme by human monocytes and macrophages. J Clin Lab Immunol 20:101, 1986
11. Legoedec J, Gasque P, Jeanne JF, Fontaine M: Expression of the complement alternative pathway by human myoblasts in vitro: biosynthesis of C3, factor B, factor H and factor I. Eur J Immunol 25:3460-3466, 1995
12. Liszewski MK, Farries TC, Lublin DM, Rooney IA, Atkinson JP: Control of the complement system. Adv Immunol 61:201-283, 1996
13. Miltenburg AMM, Meijer-Paape ME, Daha MR, Paul LC: Short-term lymphokine stimulation of human peripheral blood mononuclear cells generates cytolytic activity against endothelial cells: involvement of natural killer cells. Immunology 65:107-112, 1988
14. Morgan BP: Effects of membrane attack complex of complement on nucleated cells. Curr Top Microbiol Immunol 178:115-140, 1992
15. Morgan BP, Gasque P: Expression of complement in the brain: role in health and disease. Immunol Today 17:461-466, 1996
16. Pasch MC, Okada N, Bos JD, Asghar SS: Effects of UVB on the synthesis of complement proteins by keratinocytes. J Invest Dermatol 111:683-688, 1998
17. Pasch MC, Bos JD, Daha MR, Asghar SS: Transforming growth factor-β isoforms regulate the surface expression of membrane cofactor protein (CD46) and CD59 on human keratinocytes. Eur J Immunol 29:100-108, 1999
18. Sheenn NS, Zhou W, Adler S, Sacks SH: TNF-alpha regulation of C3 gene expression and protein biosynthesis in rat glomerular endothelial cells. Kidney Int 51:703-710, 1997
19. Terui T, Ishii K, Ozawa M, Tabata N, Kato T, Tagami H: C3 Production of cultured human epidermal keratinocytes is enhanced by IFN-gamma and TNF-alpha through different pathways. J Invest Dermatol 108:62-67, 1997
20. Teunissen MB, Koomen CW, de Waal M, Wierenga EA, Bos JD: Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J Invest Dermatol 111:645-649, 1998
21. Timmmerman J, van der Woude FJ, Gijlswijk-Janssen DJ, van Verweij CL, Es LA, Daha MR: Differential expression of complement components in human fetal and adult kidneys. Kidney Int 49:730-740, 1996
22. Volanakis JE: Transcriptional regulation of complement genes. Annu Rev Immunol 13:277-305, 1995
23. Watanabe I, Horiuchi T, Fujita S: Role of protein kinase C activation in synthesis of complement components C2 and factor B in interferon-gamma-stimulated human fibroblasts, glioblastoma cell line A172 and monocytes. Biochem J 305:425-431, 1995
24. Yancey K, Overholster O, Domloge-Hultsch N, Li L-J, Wright Caughman S, Bisalbtra P: Human keratinocytes and A431 cells synthesize and secrete factor B, the major zymogen protease of the alternative complement pathway. J Invest Dermatol 98:379-383, 1992