Mechanisms of gender-specific TCDD-induced toxicity in guinea pig adipose tissue

Reproductive Toxicology

Volumn 12, Issue 3, 1998, Pages 357-369

  Enan, Essam ^a   El Sabeawy, Faten ^a   Overstreet, James ^a   Matsumura, Fumio ^a   Lasley, Bill ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AhR; Genders; Guinea pig; MAPKs; PKC; Ras; Src; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR; ESTRADIOL; GELDANAMYCIN; MICROSOME ENZYME; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; PROTEIN-TYROSINE KINASE C-SRC; QUINONE DERIVATIVE; RAS PROTEIN; STAUROSPORINE;

ADIPOSE TISSUE; ANIMAL; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; FEMALE; GUINEA PIG; MALE; METABOLISM; MOUSE; NONHUMAN; SEQUENCE HOMOLOGY; SEX DIFFERENCE; SEXUAL DEVELOPMENT; TOXICITY TESTING; TRANSGENIC MOUSE; WASTING SYNDROME;

ADIPOSE TISSUE; ANIMALS; BENZOQUINONES; BODY WEIGHT; ENZYME INDUCTION; ENZYME INHIBITORS; ESTRADIOL; FEMALE; GUINEA PIGS; LACTAMS, MACROCYCLIC; MALE; MICE; MICE, TRANSGENIC; PROTEIN-TYROSINE KINASES; QUINONES; RAS PROTEINS; SEX CHARACTERISTICS; SRC HOMOLOGY DOMAINS; TETRACHLORODIBENZODIOXIN;

EID: 0032081182     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(98)00017-3     Document Type: Article

References (59)

1. Poland A, Knutson JC. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons Examination of the mechanism of toxicity . Annu Rev Pharmacol Toxicol. 22:1982;517-554.
2. Whitlock JP Jr. Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action. Annu Rev Pharmacol Toxicol. 30:1990;251-277.
3. Brewster DW, Matsumura F. TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) reduces lipoprotein lipase activity in the adipose tissue of the guinea pig. Biochem Biophys Res Commun. 122:1984;810-817.
4. Enan E, Liu PCC, Matsumura F. 2,3,7,8-tetrachlorodibenzo-p-dioxin causes reduction of glucose transporting activities in the plasma membranes of adipose tissue and pancreas from the guinea pig. J Biol Chem. 267:1992;19785-19791.
5. Olsen H, Enan E, Matsumura F. Regulation of glucose transport in the NIH 3T3 L1 pre-adipocyte cell line by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Environ Health Perspect. 102:1994;454-458.
6. Enan E, Matsumura F. 2,3,7,8-tetrachlorodibenzo-p-dioxin induced alterations in protein phosphorylation in guinea pig adipose tissue. J Biochem Toxicol. 8:1993;89-99.
7. Enan E, Matsumura F. Significance of TCDD-induced in protein phosphorylation in the adipocyte of male guinea pigs. J Biochem Toxicol. 9:1994;159-170.
8. Kociba RJ, Schwetz BA. A review of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with a comparison of the toxicity of other chlorinated dioxin isomers. Assoc Food Drug Officials Quart Bull. 46:1982;168-188.
9. Enan E, Matsumura F. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced changes in glucose transporting activity in guinea pigs, mice, and rats in vivo and in vitro. J Biochem Toxicol. 9:1994;97-106.
10. Enan E, Overstreet J, Matsumura F, Lasley B. Gender differences in the mechanism of dioxin toxicity in rodents and in nonhuman primates. Reprod Toxicol. 10:1996;401-411.
11. Reyes H, Reisz-Porszasz S, Hankinson O. Identification of the Ah receptor nuclear translocator protein (arnt) as a component of the DNA binding form of the Ah receptor. Science (Washington DC). 256:1992;1193-1195.
12. Whitelaw M, Pongratz I, Wilhelmsson A, Gustafsson J-A, Poellinger L. Ligand-dependent recruitment of the arnt coregulator determines DNA recognition by the dioxin receptor. Mol Cell Biol. 13:1993;2504-2514.
13. Denison MS, Fisher JM, Whitlock JP Jr. The DNA recognition site for the dioxin-Ah receptor complex nucleotide sequence and functional analysis . J Biol Chem. 263:1988;17221-17224.
14. Poland A, Kimbrough RD. Biologic mechanisms of dioxin action. Banbury report 18. 1984;500 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
15. Hudson LG, Toscano WA, Greenlee WF. Regulation of epidermal growth factor binding in a human keratinocyte cell line by 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 77:1985;251-259.
16. Karenlampi SO, Eisen HJ, Hankinson O, Nebert DW. Effects of cytochrome P1-450 inducers on the cell-surface receptors for epidermal growth factor, phorbol 12,13-dibutyrate, or insulin of cultured mouse hepatoma. J Biol Chem. 258:1983;10378-10383.
17. Kawamoto T, Matsumura F, Madhukar DV, Bombick DW. Effects of TCDD on the EGF receptor of XB mouse keratinizing epithelial cell. J Biochem Toxicol. 4:1989;173-182.
18. Madhukar BV, Ebner K, Matsumura F, Bombick DW, Brewster DW, Kawamoto T. 2,3,7,8-tetrachlorodibenzo-p-dioxin causes an increase in protein kinases associated with epidermal growth factor receptor in the hepatic plasma membrane. J Biochem Toxicol. 3:1988;261-277.
19. Matsumura F, Brewster DW, Madhukar BV, Bombick DW. Alteration of rat hepatic plasma membrane functions by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Arch Environ Contam Toxicol. 13:1984;509-515.
20. Matsumura F, Madhukar BV, Bombick DW, Brewster DW. Toxicological significance of pleiotropic changes of plasma membrane functions particularly that of EGF receptor caused by 2,3,7,8-TCDD. Banbury Report 18 Biologic mechanisms of dioxin action . 1985;267 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
21. Moriya M, Matsumura F, Kalimi GH. 2,3,7,8-Tetrachlorodibenzo-p-dioxin reduces high affinity binding to epidermal growth factor to cell surface receptors in C 10+ 1/2 cells. J Biochem Toxicol. 1:1986;45-54.
22. Bombick DW, Jankun J, Tullis K, Matsumura F. 2,3,7,8-tetrachlorodibenzo-p-dioxin causes increases in expression of c-erb-A and levels of protein-tyrosine kinases in selected tissues of responsive mouse strains. Proc Natl Acad Sci USA. 85:1988;4128-4132.
23. Bombick DW, Matsumura F. 2,3,7,8-tetrachlorodibenzo-p-dioxin causes elevation of the levels of the protein tyrosine kinase 60src. J Biochem Toxicol. 2:1987;141-154.
24. Rodriguez M, Berman J, Gilmer TM. Involvement of pp60c-Src with two major signaling pathways in human breast cancer. Proc Natl Acad Sci USA. 91:1994;83-87.
25. Maa MC, Leu TH, McCarley DJ, Schatzman RC, Parsons SJ. Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src implications for the etiology of multiple human cancers . Proc Natl Acad Sci USA. 92:1995;6981-6985.
26. Stover DR, Becke M, Liebetanz J, Lydon WB. Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha. J Biol Chem. 270:1995;15591-15597.
27. Sun XJ, Wang LM, Zhang Y, Yenush L, Myers MG Jr, Glasheen E, Lane WS, Pierce JH, White MF. Role of IRS-2 in insulin and cytokine signalling. Nature (London). 377:1995;173-177.
28. Misrahi M, Loosfelt H, Atger M, Sar S, Guiochon-Mantel A, Milgrom E. Cloning, sequencing and expression of human TSH receptor. Biochem Biophys Res Commun. 166:1990;394-403.
29. Privalsky ML. A subpopulation of the v-erb A oncogene protein, a derivative of a thyroid hormone receptor, associates with heat shock protein 90. J Biol Chem. 266:1991;1456-1462.
30. Kim BY, Ahn SC, Oh HK, Lee HS, Mheen TI, Rho HM, Ahn JS. Inhibition of PDGF-induced phospholipase D but not phospholipase C activation by herbimycin A. Biochem Biophys Res Commun. 212:1995;1061-1067.
31. Koch CA, Anderson D, Moran MF, Ellis C, Pawson T. SH2 and SH3 domains elements that control interactions of cytoplasmic signaling proteins . Science (Washington DC). 252:1991;668-674.
32. Boyce BF, Chen H, Soriano P, Mundy GR. Histomorphometric and immunocytochemical studies of Src-related osteopetrosis. Bone. 14:1993;335-340.
33. Whitelaw ML, Hutchison K, Perdew GH. A 50-kDa Cytosolic protein complexed with the 90-kDa heat shock protein (hsp90) is the same protein complexed with pp60v-src hsp90 in cells transformed by the rows sarcomavirus. J Biol Chem. 266:1991;16436-16440.
34. Talmage DA, Riney C, Benjamin TL. Regulation of pp60c-src expression in rat and mouse fibroblasts by an inducible antisense gene effects on serum regulation of growth and polyoma middle T function . Cell Growth Differ. 2:1991;51-58.
35. src, hsp90 and p50 in a cell-free system. J Biol Chem. 267:1992;2902-2908.
36. Perdew GH. Association of the Ah receptor with the 90-kDa heat shock protein. J Biol Chem. 263:1988;13802-13805.
37. Garcia TT, Buchou JM, Renoir J, Mester T, Baulieu EE. A protein kinase copurified with chick oviduct progesterone receptor. Biochemistry. 25:1986;7937-7942.
38. Enan E, Matsumura F. Identification of c-Src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway. Biochem Pharmacol. 52:1996;1599-1612.
39. Kyriakis JM, App H, Zhang X-F, Banerjee P, Brautigan DL, Rapp UR, Avruch J. Raf-1 activates MAP kinase-kinase. Nature (London). 358:1992;417-421.
40. Daum G, Eisenmann-Tappe I, Fries H-W, Troppmair J, Rapp UR. The ins and outs of Raf kinases. Trends Biochem Sci. 19:1994;474-479.
41. Lopez-Illasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI3-kinase. Science (Washington DC). 275:1997;394-397.
42. Bradfield CA, Glover E, Poland A. Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/6J mouse. Mol Pharmacol. 39:1991;13-19.
43. Burbach KM, Poland A, Bradfield CA. Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcriptional factor. Proc Natl Acad Aci USA. 89:1992;8185-8189.
44. Poland A, Glover E, Bradfield CA. Characterization of polyclonal antibodies to the Ah receptor prepared by immunication with a synthetic peptide hapten. Mol Pharmacol. 39:1991;20-26.
45. Yamaki H, Nakajima M, Seimiya H, Saya H, Sugita M, Tsuruo T. Inhibition of the association with nuclear matrix of pRB, p70 and p40 proteins along with the specific suppression of c-MYC expression by geldanamycin, an inhibitor of Src tyrosine kinase. J Antibiot. 48:1995;1021-1026.
46. Dignam ID, Lebouitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acid Res. 11:1983;1475-1489.
47. Enan E, Matsumura F. Evidence for a second pathway in the action mechanism of TCDD significance of Ah-receptor mediated activation of protein kinase under cell-free conditions . Biochem Pharmacol. 49:1995;249-261.
48. Enan E, Matsumura F. Regulation of AP-1 activity by TCDD through nuclear protein phosphorylation in adipose tissue of guinea pig. Biochem Pharmacol. 50:1995;1199-1206.
49. Enan E, El-Sabeawy F, Moran F, Overstreet JW, Lasley BL. TCDD interrupts estradiol signal transduction through the protein phosphorylation pathway in adipose tissues from immature and mature female rats. Biochem Pharmacol. 1998;In press.
50. Puga A, Nebert DW, Carrier F. Dioxin induces expression of c-fos and c-jun protooncogenes and a large increase in transcription factor AP-1. DNA Cell Biol. 11:1992;269-281.
51. Loo LW, Berestecky JM, Kanemitsu MY, Lau AF. pp60src-mediated phosphorylation of connexin 43, a gap junction protein. J Biol Chem. 270:1995;12751-12761.
52. Brissette JL, Kumar NM, Gilula NB, Dotto GP. The tumor promoter 12-0-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins. Mol Cell Biol. 11:1991;5364-5371.
53. De Haan LH, Simons JW, Bos AT, Aarts JM, Denison MS, Brouwer A. Inhibition of intercellular communication by TCDD and dioxin-like PCBs in mouse hepatoma cells. Toxicol Appl Pharmacol. 129:1994;283-293.
54. Baker TK, Kwiakowski AP, Maduhkar BV, Klaunig JE. Inhibition of gap junctional intercellular communication by TCDD in rat heaptoma cells. Carcinogenesis (London). 16:1995;2321-2326.
55. Trosko JE, Chang CC, Maduhkar BV. The role of modulated gap junctional intercellular communication in epigenetic toxicology. Risk Analysis. 14:1994;303-312.
56. Carson-Jurica MA, Schrader WT, O'Malley B. Steroid receptor family structure function. Endo Rev. 11:1990;201-232.
57. Poiger H, Schlatter C. Animal toxicology of chlorinated dibenzo-p-dioxins. Chemosphere. 12:1983;453-462.
58. McConnell EE. Acute and chronic toxicity, carcinogenesis, reproduction teratogenesis and mutagenesis in animals. Kimbrough RD. Halogenated biophenyls, terphenyls, napthalenes, dibenzodioxins and related products. 1980;109-150 Elsevier, Amsterdam.
59. Safe SH. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu Rev Pharmacol Toxicol. 26:1986;371-399.