Differential binding of urokinase and peptide antagonists to the urokinase receptor: Evidence from characterization of the receptor in four primate species

Biological Chemistry

Volumn 382, Issue 3, 2001, Pages 435-442

  Engelholm, L H ^a   Behrendt, N ^a  

^a FINSEN LABORATORY   (Denmark)

Author keywords

Anti metastatic therapy; Extracellular proteolysis; Plasminogen activator; Proteolytic cascade system; Species specificity; UPAR

Indexed keywords

LIGAND; MEMBRANE PROTEIN; PEPTIDE; PLASMINOGEN; PROTEIN INHIBITOR; RECEPTOR BLOCKING AGENT; RECEPTOR PROTEIN; UROKINASE; UROKINASE RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CANCER CELL; CANCER INVASION; CELL SURFACE; CERCOPITHECIDAE; CHIMPANZEE; CLONE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CROSS REACTION; DRUG TARGETING; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; MONKEY; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMINOGEN ACTIVATION; PRIMATE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RECEPTOR BINDING; SEQUENCE ANALYSIS; SPECIES; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CLONING, MOLECULAR; HAPLORHINI; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDES; PRIMATES; RECEPTORS, CELL SURFACE; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; URINARY PLASMINOGEN ACTIVATOR;

ANIMALIA; CERCOPITHECIDAE; CERCOPITHECUS AETHIOPS; PAN TROGLODYTES; PRIMATES;

EID: 0035031385     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2001.053     Document Type: Article

References (32)

1. Plasminogen activator inhibitor from human fibrosarcoma cells binds urokinase-type plasminogen activator, but not its proenzyme
2. The urokinase-type plasminogen activator system in cancer metastasis: A review
3. The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases
4. The urokinase receptor
5. 2- terminal amino acid sequence and glycosylation variants
6. The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator
7. Cellular receptor for urokinase-type plasminogen activator: Protein structure
8. Domain interplay in the urokinase receptor - Requirement for the third domain in high affinity ligand binding and demonstration of ligand contact sites in distinct receptor domains
9. A urokinase receptor-associated protein with specific collagen binding properties
10. Inhibition of the interaction of urokinase-type plasminogen activator (uPA) with its receptor (uPAR) by synthetic peptides
11. Prevention of metastasis by inhibition of the urokinase receptor
12. Binding of single-chain prourokinase to the urokinase receptor of human U937 cells
13. Structure of a soluble, glycosylated form of the human complement regulatory protein CD59
14. Mapping part of the functional epitope for ligand binding on the receptor for urokinase-type plasminogen activator by site-directed mutagenesis
15. High-affinity urokinase receptor antagonists identified with bacteriophage peptide display
16. Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain
17. Cancer invasion and tissue remodeling: Common themes in proteolytic matrix degradation
18. Inhibition of metastasis of Lewis lung carcinoma by a synthetic peptide within growth factor-like domain of urokinase in the experimental and spontaneous metastasis model
19. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
20. Different mechanisms are involved in the antibody mediated inhibition of ligand binding to the urokinase receptor: A study based on biosensor technology
21. Urokinase receptor mRNA level and gene transcription are strongly and rapidly increased by phorbol myristate acetate in human monocyte-like U937 cells
22. Epitope-mapped monoclonal antibodies as tools for functional and morphological analyses of the human urokinase receptor in tumor tissue
23. Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice
24. r receptor protein for urokinase-type plasminogen activator. Identification in human tumor cell lines and partial purification
25. Identification of specific sites involved in ligand binding by photoaffinity labeling of the receptor for the urokinase-type plasminogen activator. Residues located at equivalent positions in uPAR domains I and assembly of a composite ligand-binding site
26. Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly- 6 family and snake venom alpha-neurotoxins
27. 2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins
28. Chemical modification of the urokinase-type plasminogen activator and its receptor using tetranitromethane. Evidence for the involvement of specific tyrosine residues in both molecules during receptor-ligand interaction
29. Photoaffinity labeling of the human receptor for urokinase-type plasminogen activator using a decapeptide antagonist. Evidence for a composite ligand-binding site and a short interdomain separation
30. Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis
31. Urokinase receptor antagonist: Discovery and application to in vivo models of tumor growth
32. r 55,000 form of the human plasminogen activator, urokinase