Met protein and hepatocyte growth factor (HGF) in papillary carcinoma of the thyroid: Evidence for a pathogenetic role in tumourigenesis

Journal of Pathology

Volumn 194, Issue 1, 2001, Pages 4-8

  Ruco, Luigi P ^a   Stoppacciaro, Antonella ^a   Ballarini, Francesca ^a   Prat, Maria ^b   Scarpino, Stefania ^a  

^a Cattedra di Igiene   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Dendritic cells; HGF; Invasiveness; MET protein; Papillary carcinoma; Thyroid; Tumour

Indexed keywords

CHEMOKINE; ONCOPROTEIN; PARAFFIN; REAGENT; RNA; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; TUMOR MARKER; UNCLASSIFIED DRUG; UROKINASE; UROKINASE RECEPTOR;

BINDING AFFINITY; CANCER INVASION; CARCINOGENESIS; CELL COMMUNICATION; CELL INVASION; CELL MOTILITY; CELL TRANSFORMATION; CLINICAL FEATURE; DENDRITIC CELL; GENE ACTIVATION; GENE CONTROL; GENE OVEREXPRESSION; GENE REARRANGEMENT; GENETIC TRANSCRIPTION; GRAVES DISEASE; HASHIMOTO DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; LYMPH NODE METASTASIS; MOLECULAR GENETICS; MULTIPLE CANCER; MUTATION; ONCOGENE RAS; ONCOGENE RET; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTO ONCOGENE; REVIEW; STAINING; THYROID CELL; THYROID DISEASE; THYROID GLAND; THYROID PAPILLARY CARCINOMA; TUMOR CELL;

CARCINOMA, PAPILLARY; CELL TRANSFORMATION, NEOPLASTIC; HEPATOCYTE GROWTH FACTOR; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTORS, GROWTH FACTOR; THYROID NEOPLASMS; TRANS-ACTIVATORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0035031095     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.847     Document Type: Review

References (69)

1. Tyrosine kinase receptor indistinguishable from the c-met protein
2. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
3. Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-met
4. Characterization of the tpr-met oncogene p65 and the met proto-oncogene p140 protein-tyrosine kinases
5. Biosynthesis of the protein encoded by the c-MET proto-oncogene
6. A multifunctional docking site mediates signalling and transformation by the hepatocyte growth factor/scatter factor receptor family
7. Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
8. Hepatocytes and scatter factor
9. Scatter factor hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development
10. Hepatocyte growth factor specifically binds to sulfoglycolipids
11. Expression of HGF/SF, HGF1/MSP, and c-met suggests new functions during early chick development
12. Expression of the met-receptor and its ligand, HGF-SF, during mouse embryogenesis
13. Co-expression of the HGF/SF and c-met genes during early mouse embryogenesis precedes reciprocal expression in adjacent tissues during organogenesis
14. The receptor encoded by the human c-MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors
15. Expression of the met/HGF receptor in normal and neoplastic human tissues
16. Expression of hepatocyte growth factor gene in endothelial and Kupffer cells of damaged rat livers, as revealed by in situ hybridization
17. Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of inter-cellular junctions in transformed and non-transformed cell lines, basolateral polarization of c-met receptor in transformed and epithelia, and induction of rapid wound repair in a transformed model epithelium
18. Scatter factor and c-Met receptor: A paradigm for mesenchymal/epithelial interaction
19. Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors
20. Molecular cloning of a new transforming gene from a chemically transformed human cell line
21. Mechanism of met oncogene activation
22. The TPR-Met oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions
23. Overexpression and amplification of the met/hgf receptor gene during the progression of colorectal cancer
24. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
25. Overexpression of the c-met/hgf receptor gene in human thyroid carcinomas
26. Overexpression of the met/HGF receptor in ovarian cancer
27. Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer
28. Activated ras and ret oncogenes induce overexpression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells
29. Rearrangements of RET and NTRK1 tyrosine kinase receptors in papillary thyroid carcinomas
30. Expression of Met protein in thyroid tumours
31. Negative/low expression of the Met/hepatocyte growth factor receptor identifies papillary thyroid carcinomas with high risk of distant metastases
32. c-Met expression of thyroid tissue with special reference to papillary carcinoma
33. Expression of the hepatocyte growth factor and c-met in normal thyroid, non-neoplastic, and neoplastic nodules
34. Expression of Met protein and urokinase-type plasminogen activator receptor (uPA-R) in papillary carcinoma of the thyroid
35. Papillary carcinoma of the thyroid: Hepatocyte growth factor (HGF) stimulates tumor cells to release chemokines active in recruiting dendritic cells
36. Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
37. Invasion of brain tissue by primary glioma: Evidence for the involvement of urokinase-type plasminogen activator as an activator of type IV collagenase
38. Proteases of cell adhesion proteins in cancer
39. Focalized proteolysis: Spatial and temporal regulation of extracellular matrix degradation at the cell surface
40. Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-signalling in human cells concomitant with induction of the urokinase proteolysis network
41. Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF
42. Mitogenic, dedifferentiating, and scattering effects of hepatocyte growth factor on dog thyroid cells
43. Mitogenic stimulation of normal and oncogene-transformed human thyroid epithelial cells by hepatocyte growth factor
44. Hepatocyte growth factor (HGF) stimulates tumour invasiveness in papillary carcinoma of the thyroid
45. Met overexpression confers HGF-dependent invasive phenotype to human thyroid carcinoma cells in vitro
46. Proliferative activity of human thyroid tumors evaluated by proliferating cell nuclear antigen/cyclin immunohistochemical studies
47. Growth activity in hyperplastic and neoplastic human thyroid determined by an immunohistochemical staining procedure using monoclonal anti-body MIB-1
48. Growth factor regulation of integrin-mediated cell motility
49. Growth factor-dependent activation of alphavbeta3 integrin in normal epithelial cells: Implications for tumor invasion
50. HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells
51. Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor
52. Rapid detection of specific messenger RNAs in thyroid carcinomas by reverse transcription-PCR with degenerate primers: Specific expression of oncofetal fibronectin messenger RNA in papillary carcinoma
53. Expression of EDA/EDB isoforms of fibronectin in papillary carcinoma of the thyroid
54. Fibronectins: Multifunctional modular glycoproteins
55. Molecular biology of fibronectin
56. Primary structure of human fibronectin: Differential splicing may generate at least 10 polypeptides from a single gene
57. Differential expression of the ED sequence-containing form of cellular fibronectin in embryonic and adult human tissues
58. Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon
59. Alternative splicing of fibronectin: Many different proteins but few different functions
60. Modulation of cell-adhesive activity of fibronectin by the alternatively spliced EDA segment
61. Papillary carcinoma of the thyroid. A clinicopathologic study of 241 cases treated at the University of Florence, Italy
62. Cancer vaccines
63. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses
64. Origin, maturation and antigen presenting function of dendritic cells
65. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites
66. Eosinophilic granuloma of lymph nodes associated with metastatic papillary carcinoma of the thyroid
67. Langerhans cell histiocytosis of lymph nodes draining a papillary carcinoma of the thyroid
68. Langerhans cell histiocytosis associated with papillary carcinoma of the thyroid