Met overexpression confers HGF-dependent invasive phenotype to human thyroid carcinoma cells in vitro

Journal of Cellular Physiology

Volumn 180, Issue 3, 1999, Pages 365-371

  De Luca, Annarita ^a   Arena, Niccolò ^b   Sena, Luigi M ^a   Medico, Enzo ^a,c  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c CANDIOLO CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

SCATTER FACTOR; SCATTER FACTOR RECEPTOR; TYROSINE KINASE RECEPTOR;

ARTICLE; CARCINOMA CELL; CELL DIFFERENTIATION; CELL INVASION; CELL MOTILITY; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE ACTIVATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; THYROID CARCINOMA;

CARCINOMA; CELL DIVISION; CELL MOVEMENT; DRUG RESISTANCE, NEOPLASM; HEPATOCYTE GROWTH FACTOR; HUMANS; NEOPLASM INVASIVENESS; PHENOTYPE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MET; THYROID NEOPLASMS; TUMOR CELLS, CULTURED; TYROSINE; WOUND HEALING;

EID: 0032783632     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199909)180:3<365::AID-JCP7>3.0.CO;2-B     Document Type: Article

References (38)

1. Behrens J, Mareel MM, Van Roy FM, Birchmeier W. 1989. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 108: 2435-2447.
2. Bongarzone I, Pierotti MA, Monzini N, Mondellini P, Manenti G, Donghi R, Pilotti S, Grieco M, Santoro M, Fusco A, Vecchio G, Della Porta G. 1989. High frequency of activation of tyrosine kinase oncogenes in human papilary thyroid carcinoma. Oncogene 4:1457-1462.
3. Brinkmann V, Foroutan H, Sachs H, Weidner KM, Birchmeier W. 1995. Hepatocyte growth factor/scatter factor induces a variety of tissue specific morphogenic programs in epithelial cells. J Cell Biol 131:1573-1586.
4. Bussolino F, Ziche M, Wang JM, Alessi D, Morbidelli L, Cremona O, Bosia A, Marchisio PC, Mantovani A. 1991. In vitro and in vivo activation of endothelial cells by colony stimulating factors. J Clin Invest 87:986-991.
5. Cooper CS, Park M, Blair DG, Tainsky MA, Huebner K, Croce CM, Vande Woude GF. 1984. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 311: 29-33.
6. Crepaldi T, Pollack AL, Prat M, Zborek A, Mostov K, Comoglio PM. 1994. Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells. J Cell Biol 125:313-320.
7. Di Renzo MF, Narsimhan RP, Olivero M, Bretti S, Giordano S, Medico E, Gaglia P, Zara P, Comoglio PM. 1991. Expression of the Met/ HGF receptor in normal and neoplastic human tissues. Oncogene 6:1997-2003.
8. Di Renzo MF, Olivero M, Ferro S, Prat M, Bongarzone I, Pilotti S, Belfiore A, Costantino A, Vigneri R, Pierotti MA, Comoglio PM. 1992. Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas. Oncogene 7:2549-2553.
9. Di Renzo MF, Poulsom R, Olivero M, Comoglio PM, Lemoine NR. 1995. Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer. Cancer Res 55:1129-1138.
10. Fabien N, Fusco A, Santoro M, Barbier Y, Dubois PM, Paulin C. 1994. Description of a human papillary thyroid carcinoma cell line. Cancer 13:2206-2212.
11. Ferracini R, Di Renzo MF, Scotlandi K, Baldini N, Olivero M, Lollini P, Cremona O, Campanacci M, Comoglio PM. 1995. The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. Oncogene 16:739-749.
12. Fusco A, Grieco M, Santoro M, Berlingieri MT, Pilotti S, Pierotti MA, Della Porta G, Vecchio G. 1987. A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases. Nature 328:170-172.
13. Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski J, Comoglio PM. 1994. Ron is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J 13:3524-3532.
14. Giordano S, Di Renzo MF, Narsimhan RP, Cooper CS, Rosa C, Comoglio PM. 1989a. Biosynthesis of the protein encoded by the c-Met proto-oncogene. Oncogene 4:1383-1388.
15. Giordano S, Ponzetto C, Di Renzo MF, Cooper CS, Comoglio PM. 1989b. Tyrosine kinase receptor indistinguishable from the c-met protein. Nature 339:155-156.
16. Graziani A, Gramaglia D, Cantley LC, Comoglio PM. 1991. The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase. J Biol Chem 266:22087-22090.
17. Grieco M, Santoro M, Berlingieri MT, Melillo RM, Donghi R, Borganzone I, Pierotti MA, Della Porta G, Fusco A, Vecchio G. 1990. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 60:557-563.
18. Heldin CH, Ostman A. 1996. Ligand-induced dimerization of growth factor receptors: variations on the theme. Cytokine Growth Factor Rev 7:3-10.
19. Ivan M, Eccles NG, Bond JA, Prat M, Comoglio PM, Wynford-Thomas D. 1997. Activated RAS and RET oncogenes induce over-expression of hepatocyte growth factor recertor in human thyroid epitelial cells. Oncogene 14:2417-2423.
20. Jeffers M, Schmidt L, Nakaigawa N, Webb CP, Weirich G, Kishida T, Zbar B, Vande Woude GF. 1997. Activating mutations for the Met tyrosine kinase receptor in human cancer. Proc Natl Acad Sci USA 94:11445-11450.
21. Kobayashi H, Hidekazu O, Sugimura M, Shinohara H, Fuju T, Terao T. 1992. Inhibition of in vitro ovarian cancer cell invasion by modulation of urokinase-type plasminogen activator and cathepsin B. Cancer Res 52:3610-3614.
22. Laemmli UK. 1970. Klevage of structural proteins during the assembly of the head of bacteriophage T4. Nature 230:680-685.
23. Lahat N, Sheinfeld M, Sobel E, Kinarty A, Kraiem Z. 1992. Divergent effects of cytokines on human leukocyte antigen-DR antigen expression of neoplastic and non-neoplastic human thyroid cells. Cancer 69:1799-1807.
24. Massague J, Weis-Garcia F. 1996. Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals. Cancer Surv 27:41-64.
25. Medico E, Mongiovi AM, Huff J, Jelinek MA, Follenzi A, Gaudino G, Parsons JT, Comoglio PM. 1996. The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro. Mol Biol Cell 7:1-10.
26. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 16:55-63.
27. Naldini L, Tamagnone L, Vigna E, Sachs M, Hartmann G, Birchmeier W, Daikuhara Y, Tsubouchi H, Blasi F, Comoglio PM. 1992. Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J 11:4825-4833.
28. Naldini L, Vigna E, Bardelli A, Follenzi A, Galimi F, Comoglio PM. 1995. Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled in vivo by a stoichiometric reaction. J Biol Chem 270:603-611.
29. Prat M, Narsimhan RP, Crepaldi T, Nicotra MR, Natali PG, Comoglio PM. 1991. The receptor encoded by the human c-MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors. Int J Cancer 49:323-328.
30. Ponzetto C, Giordano S, Peverali F, Della Valle G, Abate ML, Vaula G, Comoglio PM. 1991. c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase. Oncogene 6:553-559.
31. Ponzetto C, Bardelli A, Zhen Z, Maina F, dalla Zonca P, Giordano S, Graziani A, Panayotou G, Comoglio PM. 1994. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 77:261-271.
32. Ruco LP, Ranalli T, Marzullo A, Bianco P, Prat M, Comoglio PM, Baroni CD. 1996. Expression of Met protein in thyroid tumors. J Pathol 180:266-270.
33. Schulte KM, Antoch G, Ellrichmann M, Finken-Eigen M, Kohrer K, Simon D, Goretzki PE, Roher HD. 1998. Regulation of the HGF-receptor c-met in the thyroid gland. Exp Clin Endocrinol Diabetes 106:310-318.
34. Takahashi MH, Thomas GA, Williams ED. 1995. Evidence for mutual interdependence of epithelium and stromal lymphoid cells in a subset of papillary carcinomas. Br J Cancer 72:813-817.
35. Tamagnone L, Comoglio PM. 1997. Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors. Cytokine Growth Factor Rev 8:129-142.
36. Van der Geer P, Hunter T, Lindberg RA. 1994. Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol 10:251-337.
37. Weidner KM, Behrens J, Vandekerckhove J, Birchmeier W. 1990. Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J Cell Biol 111:2097-2108.
38. Zarnegar R, Michalopoulos GK. 1995. The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis. J Cell Biol 129:1177-1180.