Effects of receptor-selective retinoids on CYP26 gene expression and metabolism of all-trans-retinoic acid in intestinal cells

Drug Metabolism and Disposition

Volumn 29, Issue 5, 2001, Pages 742-747

  Lampen, Alfonso ^a   Meyer, Silke ^a   Nau, Heiz ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN CYP26; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DIMERIZATION; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; INTESTINE CELL; PRIORITY JOURNAL; RECEPTOR SENSITIVITY;

CACO-2 CELLS; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTESTINES; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; TRANSCRIPTION FACTORS; TRETINOIN;

EID: 0035029849     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha
2. Enhancement of HL-60 differentiation by a new class of retinoids with selective activity on retinoid X receptor
3. Two distinct actions of retinoid-receptor ligands
4. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
5. Quantitative plasma disposition of retinol and retinyl esters after high-dose oral vitamin A administration in the cynomolgus monkey
6. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma
7. Affinity of retinoids for nuclear receptors correlates with biological activity by absence of correlation with CRABP binding
8. Selective high affinity retinoic acid receptor alpha or beta-gamma ligands
9. Transplacental pharmacokinetics and teratogenicity of a single dose of retinol (vitamin A) during organogenesis in the mouse
10. Synergistic teratogenic effects induced by combinations of synthetic and natural retinoids
11. Pattern of retinoid-induced teratogenic effects: Possible relationship with relative selectivity for nuclear retinoid receptors RAR alpha, RAR beta, and RAR gamma
12. RARalpha-mediated teratogenicity in mice is potentiated by an RXR agonist and reduced by an RAR antagonist: Dissection of retinoid receptor-induced pathways
13. Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos
14. Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/ retinoid x receptor selectivity and effects on metabolic enzymes
15. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling
16. Differential teratogenic response of mouse embryos to receptor selective analogs of retinoic acid
17. Metabolism of Vitamin A, and its active metabolite all-trans-retinoic acid in small intestinal enterocytes
18. Retinoids selective for retinoid X receptor response pathways
19. Nuclear receptor that identifies a novel retinoic acid response pathway
20. Retinoid receptors, their ligands, and teratogenesis: Synergy and specifictiy of effects
21. Signal transduction by retinoid receptors
22. A human retinoic acid receptor which belongs to the family of nuclear receptors
23. CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family
24. Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RARalpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand
25. RXR-specific agonists and modulators: A new retinoid pharmacology
26. Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells
27. Gene transcription of the retinoid X receptor alpha (RXRalpha) is regulated by fatty acids and hormones in rat hepatic cells
28. cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450