Chemoelectrical signal transduction in olfactory sensory neurons of air-breathing vertebrates

Cellular and Molecular Life Sciences

Volumn 58, Issue 4, 2001, Pages 510-519

  Frings, S ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

Chemoreception; Chloride channel; Cyclic nucleotide gated channel; Olfaction; Receptor current; Sensory physiology; Signal transduction

Indexed keywords

CALCIUM CHANNEL; CYCLIC AMP;

CHANNEL GATING; CILIATED EPITHELIUM; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; OLFACTORY NERVE; OLFACTORY RECEPTOR; REVIEW; SECOND MESSENGER; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; VERTEBRATE;

VERTEBRATA;

EID: 0035028689     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000876     Document Type: Review

References (110)

1. Analysis of the electrical activity of the olfactory epithelium
2. Studies on slow potentials in the rabbit's olfactory bulb and nasal mucosa
3. Role of cyclic adenosine-3′,5′-monophosphate in olfactory reception
4. Evidence for the specific involvement of cyclic AMP in the olfactory transduction mechanism
5. Current recording from sensory cilia of olfactory receptor cells in situ. I. The neuronal response to cyclic nucleotides
6. Odorant-sensitive adenylate cyclase may mediate olfactory reception
7. Activation of the sensory current in salamander olfactory receptor neurons depends on a G protein-mediated cAMP second messenger system
8. olf: An olfactory neuron specific-G protein involved in odorant signal tranduction
9. olf: Complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous sytem
10. olf and type III adenylyl cyclase
11. Developmental expression of G-proteins and adenylyl cyclase in peripheral olfactory systems. Light microscopic and freeze-substitution electron microscopic immunocytochemistry
12. Odorants selectively activate distinct G protein subtypes in olfactory cilia
13. Inhibition and enhancement of odorant-induced cAMP accumulation in rat olfactory cilia by antibodies directed against Gs/olf- and Gi-protein subunits
14. olf are anosmic
15. Transduction proteins of olfactory receptor cells: Identification of guanine nucleotide binding proteins and protein kinase C
16. Differential localization of G proteins, Gi and Go, in the olfactory epithelium and the main olfactory bulb of the rat
17. Olfactory adenylyl cyclase. Identification and purification of a novel enzyme form
18. Identification of a specialized adenylyl cyclase that may mediate odorant detection
19. Olfactory transduction: Cross-talk between second-messenger systems
20. Stimulation of type III olfactory adenylyl cyclase by calcium and calmodulin
21. The type III calcium/calmodulin-sensitive adenylyl cyclase is not specific to olfactory sensory neurons
22. Calcium modulates the rapid kinetics of the odorant-induced cyclic AMP signal in rat olfactory cilia
23. The odorant-sensitive adenylate cyclase of olfactory receptor cells. Differential stimulation by distinct classes of odorants
24. Odorants of the same odor class activate different second messenger pathways
25. Odorant-sensitive adenlylate cyclase: Rapid, potent activation and desensitization in primary olfactory neuronal cultures
26. Adenylate cyclase mediates olfactory transduction for a wide variety of odorants
27. Rapid kinetics of second messenger formation in olfactory transduction
28. Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells
29. Odor-induced membrane currents in vertebrate-olfactory receptor neurons
30. Membrane responses and permeability changes to odorants in the solitary olfactory receptor cells of newt
31. Noise analysis of ion channels in non-space-clamped cables: Estimates of channel parameters in olfactory cilia
32. Gating properties of the cAMP-gated channel in toad olfactory receptor cells
33. Contribution of the ciliary cyclic nucleotide-gated conductance to olfactory transduction in the salamander
34. Properties of cyclic nucleotide-gated channels mediating olfactory transduction. Activation, selectivity and blockage
35. Ultrastructural aspects of olfactory signaling
36. Localization of the olfactory cyclic nucleotide-gated channel subunit 1 in normal, embryonic and regenerating olfactory epithelium
37. A cyclic nucleotide-gated conductance in olfactory receptor cilia
38. Single odor-sensitive channels in olfactory receptor neurons are also gated by cyclic nucleotides
39. General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel
40. Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons
41. Primary structure of cAMP-gated channel from bovine olfactory epithelium
42. Heteromeric olfactory cyclic nucleotide-gated channels: A subunit that confers increased sensitivity to cAMP
43. A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP
44. An isoform of the rod photoreceptor cyclic nucleotide-gated channel subunit expressed in olfactory neurons
45. The native rat olfactory cyclic nucleotidegated channel is composed of three distinct subunits
46. Structural basis for ligand sensitivity of heteromeric olfactory cyclic nucleotidegated channels
47. Analysis of single cyclic nucleotide-gated channels in olfactory receptor cells
48. Cyclic nucleotide-activated channels in the frog olfactory receptor plasma membrane
49. High-gain, low-noise amplification in olfactory transduction
50. Divalent cations block the cyclic nucleotide-gated channel of olfactory receptor neurons
51. Block by external calcium and magnesium of the cyclic-nucleotide-activated conductance in isolated olfactory cilia
52. Profoundly different calcium permeation and blockage determine the specific function of distinct cyclic nucleotide-gated channels
53. 2+ permeation in cyclic nucleotide-gated channels
54. 2+-binding site in the pore of cyclic nucleotide-gated channels: S5/S6 segments control affinity ofintrapore glutamates
55. Ion concentrations in the mucus covering the olfactory epithelium in rodents
56. Calcium entry through cyclic nucleotidegated channels in individual cilia of olfactory receptor cells: Spatiotemporal dynamics
57. Imaging odor-induced calcium transients in single olfactory cilia: Specificity of activation and role in transduction
58. Calcium-activated chloride conductance in frog olfactory cilia
59. Co-existence of cationic and chloride components in odorant-induced current of vertebrate olfactory receptor cells
60. Origin of the chloride current in olfactory transduction
61. Characterization of calcium-activated chloride channels in patches excised from the dendritic knob of mammalian olfactory receptor neurons
62. A depolarizing chloride current contributes to chemo-electrical transduction in olfactory sensory neurons in situ
63. Direct measurement of the chloride concentration in newt olfactory receptors with the fluorescent probe
64. Odor-induced currents in Xenopus olfactory receptor cells measured with perforatedpatch recording
65. Action potentials and chemosensitive conductances in the dendrites of olfactory neurons suggest new features for odor transduction
66. Persistence of the olfactory receptor current in a wide variety of extracellular environments
67. - conductance to amino-acid-induced inward current responses of ciliated olfactory neurons of the rainbow trout
68. The relation between stimulus and response in olfactory receptor cells of the tiger salamander
69. 2+calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons
70. Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel
71. Calcium-dependent modulation of the agonist affinity of the mammalian olfactory cyclic nucleotide-gated channel by calmodulin and a novel endogenous factor
72. Mechanism of odorant adaptation in the olfactory receptor cell
73. Molecular cloning and characteriza tion of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons
74. Ca2+ inhibition of type III adenylyl cyclase in vivo
75. Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in neurons: A mechanism for attenuation of olfactory signals
76. The calcium-binding protein VILIP in olfactory neurons: Regulation of second messenger signaling
77. Termination of second messenger signaling in olfaction
78. A β-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination
79. β-adrenergic receptor kinase-2 and β-arrestin-2 as mediators of odorant-induced desensitization
80. Olfactory desensitization requires membrane targeting of receptor kinase mediated by-subunits of heterotrimeric G proteins
81. Phosducin, potential role in modulation of olfactory signaling
82. Sodium/calcium exchanger in olfactory receptor neurones of Xenopus laevis
83. Sodium/calcium exchanger in rat olfactory neurons
84. 2+ extrusion governs response recovery in frog olfactory receptor cells
85. +-ATPase in rodent olfactory epithelium
86. +-ATPase in the rat's olfactory epithelial surface
87. 2+-ATPase in plasma membrane-rich preparations from olfactory epithelium of Atlantic salmon
88. Action potentials initiated by single channels opening in a small neuron (rat olfactory receptor)
89. Excitable properties of olfactory receptor neurons
90. + channels in rat olfactory receptor neurons
91. Odorant response of isolated olfactory receptor cells is blocked by amiloride
92. 2+ channel lowers the threshold of spike generation in the newt olfactory receptor cell
93. 2+ current contributions on spike initiation in the newt olfactory receptor cell
94. Adrenaline enhances odorant contrast by modulating signal encoding in olfactory receptor cells
95. h) in cultured rat olfactory receptor neurons
96. Neuromodulatory effects of gonadotropin releasing hormone on olfactory receptor neurons
97. Differential distribution of six calcium-binding proteins in the rat olfactory epithelium during postnatal development and adulthood
98. Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants
99. i by activating two distinct current components in vertebrate olfactory receptor cells
100. Characterization of inositol-1,4,5-trisphosphate-gated channels in the plasma membrane of rat olfactory neurons
101. Gaseous second messengers in vertebrate olfaction
102. Implications of the NO/cGMP system for olfaction
103. Identification of a long-lasting form of odor adaptation that depends on the carbon monoxide/cGMP second messenger system
104. Nitric oxide inhibition of the rat olfactory cyclic nucleotide-gated cation channel
105. Guanylate cyclase in olfactory cilia from rat and pig
106. Modulation by cyclic GMP of the odour sensitivity of vertebrate olfactory receptor cells
107. A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons
108. A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway
109. A cGMP-signalling pathway in a subset of olfactory sensory neurons
110. Controversial issues in vertebrate olfactory transduction