Drug action on poly(A) polymerase activity and isoforms during U937 cell apoptosis

Journal of Experimental and Clinical Cancer Research

Volumn 20, Issue 1, 2001, Pages 63-69

  Balatsos, N A A ^a   Lallas, G ^a   Havredaki, M ^a   Tsiapalis, C M ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

Author keywords

Cell apoptosis; Drug action; Poly(A) polymerase; U937 cells

Indexed keywords

DNA FRAGMENT; FLUOROURACIL; INTERFERON; POLYNUCLEOTIDE ADENYLYLTRANSFERASE;

APOPTOSIS; ARTICLE; CELL STRAIN U937; DNA STRAND BREAKAGE; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL;

APOPTOSIS; CYTOPLASM; DNA FRAGMENTATION; FLUOROURACIL; HUMANS; INTERFERON-ALPHA; ISOENZYMES; KINETICS; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; U937 CELLS;

EID: 0035024258     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Modulation of fluorouracil by N-(phosphonacetyl)-L-aspartate
2. Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignacies
3. Partial sychronization of L1210 cells by 5-fluorouracil and its use in drug combinations
4. Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartatic acid
5. Effects of 5-fluorouracil on dihydrofolate reductase mRNA from methotrexate-resistant KB cells
6. Acute effect of 5-fluorouracil on cytoplasmic and nuclear dihydrofolate reductase messenger RNA metabolism
7. 5-fluorouracil augmentation of dihydrofolate reductase gene transcripts containing intervening sequences in methotrexate-resistant KB cells
8. Early 5-fluorouracil induced changes of poly(A) polymerase in HeLa and WISH cells
9. Anticancer drug action on poly(A) polymerase activity and isoforms during HeLa and WISH apoptosis
10. Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells
11. Effect of 5-fluorouracil on the cell growth and cell cycle kinetics of mouse ascites tumor growing in vivo
12. Effects of perturbations of deoxyribonucleoside triphosphates on expression of ribocucleotide reductase, a G I/S transition state enzyme, in p 53 mutated cells
13. Cyclins and Cancer II: CvctinD and CDK inhibitors come of age
14. Effect of 5-fluorouracil on cell cycle regulatory proteins in human colon cancer cell lines
15. How interferons fight disease
16. Mechanisms of interferon's antitumor action
17. Interferons as biomodulators of fluorpyrimidines in the treatment of colorectal cancer
18. Synergetic effects of retrovirus IFN-alpha gene transfer and 5-FU on apoptosis of colon cancer cells
19. Adjuvant 5-fluorouracil and leucovorin with or without interferon alfa-2a in colon carcinoma: National Surgical Adjuvant Breast and Bowel Project protocol C-05
20. Biomodulation of fluorouracil in colorectal cancer
21. γ-interferon and expression in MHC-genes regulate peptide hydrolysis by proteasomes
22. Rcgulation of cytokine gene expression
23. 3′-end cleavage and polyadenylation of mRNA precursors
24. Poly(A) shortening and degradation of the 3′ A+U -rich sequences of human c-myc mRNA in a cell-free system
25. Removal of poly(A) tail and consequent degradation of c-fos mRNA fascilitated by the AU-rich sequences
26. mRNA degradation: A tale of poly(A) and multiprotein machines
27. Complex alternative RNA processing generated an unexpected diversity of poly(A) polymerase isoforms
28. Multiple forros of poly(A) polymerases in human cells
29. Biochemical and immunological identification and enrichment of poly(A) polymerase from human thymus
30. Cell-cycle related regulation of poly(A) polymerase by phosphorylation
31. Inhibition of poly(A) polymerase requires p34 cdc2/cyclinB phosphorylation of multiple consensus and non-consensus sites
32. Involvement of the carboxyl terminus of vertebrate poly(A) polymerase in UIA autoregulation and in the coupling of splicing and polyadenylation
33. Dephosphorylation, proteolysis and reduced activity of poly(A) polymerase associated with U937 cell apoptosis
34. Very short-lived and stable mRNA from resting human lymphocytes
35. Protein measurement with the folin phenol reagent
36. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
37. Western blotting. Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A
38. A rapid, sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on western blots
39. Purification of terminal riboadenylate transferase from calf thymus gland
40. Polyadenylic acid polymerase in normal and leukemic human leukocytes
41. Assays for DNA fragmentation, endonucleases, and intracellular pH and Ca2+ associated with apoptosis
42. Regulation of mRNA polyadenylation - Deadenylation
43. Polyadenylate polymerase
44. Regulation of eukaryotic messenger RNA turnover
45. Increase in the levels of activity of polyadenylic acid metabolizing enzymes following phytohaematogglutinin stimulation of human leukocytes
46. Polyadenylate polymerase activity in stationary and growing cell cultures
47. The value of poly(A) polymerase as a prognostic biochemical marker in chronic lymphocytic leukemia
48. Regulation between the activity of poly(A) polymerase and the levels of protein synthesis in the lymphocytes of patients with chronic lymphocytic leukemia
49. Patterns of adenosine deaminase, ecto-5′-nucleosidase, poly(A) polymerase and surface light chain expression in chromic lymphocytic leukemias
50. Interferon-caused alterations of poly(A) polymerase activity levels in established cell lines
51. Poly(A) polymerase from HeLa cells is increased by the antitumor drug bleomycin
52. Correlation of poly(A) polymerase and adenosine deaminase activity leveis with cytotoxic effects of coformycin and 2-deoxycoformycin in cultured lymphocytes from patients with B-chronic lymphocytic leukemia
53. Poly(A) polymerase activity levels in breast tumor cytosols
54. Primary structure and expression of bovine poly(A) polymerase
55. Mutational analysis of mammalian poly(A) polymerase identifies a region for primer binding and a catalytic domain, homologous to the family X polymerases and other nucleotidyl tranferases
56. Poly(A) polymerase specifically implicated in the mechanism of chemotherapeutic drug action during cell apoptosis
57. Biomodulation of 5-fluorouracil by interferon-alpha in human renal carcinoma cells: Relationship to the expression of thymidine phosphorylase