Reduced susceptibility to apoptosis correlates with kinetic quiescence in disease progression of chronic lymphocytic leukaemia

British Journal of Haematology

Volumn 113, Issue 2, 2001, Pages 391-399

  Ricciardi, Maria R ^a   Petrucci, Maria T ^b   Gregorj, Chiara ^a   Ariola, Cristina ^a   Lemoli, Roberto M ^a   Fogli, Miram ^a,b   Mauro, Francesca R ^c   Cerretti, Raffaella ^a   Foà, Robin ^c   Mandelli, Franco ^a   Tafuri, Agostino ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c NONE

Author keywords

Apoptosis; Cell cycle; Chronic lymphocytic leukaemia; Disease progression; p27kip1

Indexed keywords

DNA; PROTEIN P27; RNA;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DISEASE COURSE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; KINETICS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; B-LYMPHOCYTES; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELL CYCLE; CELL CYCLE PROTEINS; CELLS, CULTURED; CULTURE MEDIA; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISEASE PROGRESSION; FLOW CYTOMETRY; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LYMPHOCYTES; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; T-LYMPHOCYTES; TUMOR SUPPRESSOR PROTEINS;

EID: 0035021567     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02708.x     Document Type: Article

References (45)

1. Leukemic cells from progressive B-CLL respond strongly to growth stimulation in vitro
2. Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA
3. Prognostic value of DNA/RNA flow cytometry in myeloblastic and lymphoblastic leukemia in adults: RNA content and S-phase predict remission duration and survival in multivariate analysis
4. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis
5. What does apoptosis mean in B-CLL?
6. National Cancer Institute-Sponsored Working Group Guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment
7. Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro
8. Differential induction of apoptosis by fludarabine monophosphate in leukemic B and normal T cells in chronic lymphocytic leukemia
9. Monoclonal antibody Ki-67 identified B and T cells in cycle in chronic lymphocytic leukemia: Correlation with disease activity
10. p53 expression in B-cell chronic lymphocytic leukemia: A marker of disease progression and poor prognosis
11. Relationship between RNA content and progression of lymphocytes through the S phase of the cell cycle
12. Features of apoptotic cells measured by flow cytometry
13. B-cell chronic lymphocytic leukemia: Present status and future directions
14. Inactivation of a Cdk2 inhibitors during interleukin 2-induced proliferation of human T lymphocytes
15. Interleukin-10 induces apoptotic cell death of B-chronic leukemia cells
16. bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
17. Translation control of p27 accumulation during the cell cycle
18. kip1
19. p53 mutations in human cancers
20. Annexin V for flow cytometric detection of phosphatidylserine expression on B-cells undergoing apoptosis
21. Retinoblastoma protein expression is frequently altered in chronic lymphocytic leukemia
22. Interleukin-9 (IL-9) stimulates the proliferation of human myeloid leukemic cells
23. Cyclin status of CD34+ cells mobilized into peripheral blood of healthy donors by recombinant human granulocyte colony-stimulating factor
24. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitors p27 in aggressive colorectal carcinomas
25. Clinical characteristics and outcome of young chronic lymphocytic leukemia patients: A single institution study of 204 cases
26. Interleukin-2-mediated elimination of p27 cyclin-dependent kinase inhibitors prevented by rapamycin
27. Accessory cells, cytokine loops and cell-to-cell interactions in chronic lymphocytic leukemia
28. Regulation of human cell cycle by the cdk2 protein kinase
29. "Low-risk" myelodysplastic syndrome is associated with excessive apoptosis and an increase ratio of pro-versus anti-apoptotic bcl-2 related proteins
30. Bcl-2/bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance
31. Expression of cell-cycle regulators p27 kip1 and cyclin E, alone and in combination correlate with survival in young breast cancer patients
32. Clinical staging of chronic lymphocytic leukemia
33. Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome
34. Chronic lymphocytic leukemia
35. Anomalous high p27/K1P1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression. p27/KIP1-cyclin D3 colocalization in tumor cells
36. Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia
37. Interleukin-10 mRNA expression in B-cell chronic lymphocytic leukaemia inversely correlates with progression of disease
38. Genetic features of B-cell chronic lymphocytic leukemia
39. Combination of hematopoietic growth factors containing IL-3 induce acute myeloid leukemia cells sensitization to cycle specific and cycle non-specific drugs
40. Thrombopoietin and interleukin-11 have different modulatory effects on cell cycle and programmed cell death in primary acute myeloid leukemia cells
41. The cell cycle inhibitors p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas
42. Electrophoretic transfer of protein from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
43. Apoptosis and secondary necrosis of lymphocytes in culture
44. kip1 in chronic B-cell lymphocytic leukemia
45. Hypothesis: Apoptosis may be the mechanism responsible for the premature intramedullary cell death in the myelodysplastic syndrome