Progress of gene targeting in mouse

Chinese Science Bulletin

Volumn 46, Issue 4, 2001, Pages 265-271

  Yang, Xiao ^a   Huang, Peitang ^a   Huang, Cuifen ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Chromosomal engineering; Gene knockin; Gene knockout; Gene targeting

Indexed keywords

CHROMOSOME DELETION; CHROMOSOME REARRANGEMENT; GENE DISRUPTION; GENE FUNCTION; GENE TARGETING; GENETIC ENGINEERING; MOUSE; NONHUMAN; POINT MUTATION; REVIEW;

EID: 0035019979     PISSN: 10016538     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03187183     Document Type: Review

References (41)

1. Establishment in culture of pluripotential cells from mouse embryos
2. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
3. Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
4. Targeted correction of a mutant HPRT gene in mouse embryonic stem cells
5. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
6. Transgenics on the Internet
7. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
8. The tumor suppressor SMAD4/ DPC4 is essential for epiblast proliferation and mesoderm induction in mice
9. Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
10. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
11. Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and the inner ear
12. Analysis of biological selections for high efficiency gene targeting
13. Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development
14. Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
15. Gene trapping and functional genomics
16. Viable offspring derived from fetal and adult mammalian cells
17. Dolly is a clone-and no longer alone
18. Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells
19. Site-directed point mutations in embryonic stem cells: A gene-targeting tag-and- exchange strategy
20. The strategies of gene targeting in mouse embryonic stem cells
21. Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis
22. Site-specific recombinases: Tools for genome engineering
23. FLP recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice
24. Deletion of a DNA lymerase β gene segment in T Cells using cell type-specific targeting
25. Conditional mutation of Brca 1 in mammary epithelial cells results in blunted ductal morphogenesis and tumor formation
26. An Fgf8 mutant allelic series generated by Cre- and FLP-mediated recombination
27. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene
28. Inducible gene targeting in mice
29. Diverse strategies for tetracycline-regulated inducible gene expression
30. Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter
31. Ligand-activated site-specific recombination in mice
32. Temporally and spatially regulated somatic mutagenesis in mice
33. Chromosome engineering in mice
34. Cre-midiated site-apecific translocation between nonhomologous mouse chromosomes
35. Using targeted large deletions and high-efficiency N-ethyl-N-nitrosourea mutagenesis for functional analyses of the mammalian genome
36. A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice
37. Integration and stable germ line transmission of genes injected into mouse pronuclei
38. B lymphocyte-speicific, cre-mediated mutagenesis in mice
39. Targeted integration of DNA using mutant lox sites in embryonic stem cells
40. Segmental genomic replacement in embryonic stem cells by double lox targeting
41. Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts