Functional role of matrix metalloproteinases (MMPS) in mammary epithelial cell development

Journal of Cellular Physiology

Volumn 188, Issue 1, 2001, Pages 75-88

  Lee, Ping Ping H ^a   Hwang, Jiuan Jiuan ^b   Mead, Lawrence ^a   Ip, Margot M ^a,c  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BATIMASTAT; CGS 27023A; EDETIC ACID; EPIDERMAL GROWTH FACTOR; GELATINASE; HYDROCORTISONE; MATRIX METALLOPROTEINASE; MERCURY DERIVATIVE; PROLACTIN; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BASEMENT MEMBRANE; BREAST EPITHELIUM; CELL GROWTH; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RELEASE; EXTRACELLULAR MATRIX; FEMALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT;

ANIMALS; CELL SIZE; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CULTURE MEDIA, SERUM-FREE; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; FEMALE; GELATINASES; HUMANS; HYDROXAMIC ACIDS; IMMUNOBLOTTING; MAMMARY GLANDS, ANIMAL; MATRIX METALLOPROTEINASES; MICE; ORGANOIDS; PEPTIDES; PHENYLALANINE; PHENYLMERCURY COMPOUNDS; PROTEASE INHIBITORS; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES; THIOPHENES; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0035016797     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.1090     Document Type: Article

References (63)

1. Alexander CM, Werb Z. 1989. Proteinases and extracellular matrix remodeling. Curr Opin Cell Biol 1:974-982.
2. Benaud C, Dickson RB, Thompson EW. 1998. Roles of the matrix metalloproteinases in mammary gland development and cancer. Breast Cancer Research and Treatment 50:97-116.
3. Benelli R, Adatia R, Ensoli B, Stetler-Stevenson WG, Santi L, Albini A. 1994. Inhibition of AIDS-Kaposi's sarcoma cell induced endothelial cell invasion by TIMP-2 and a synthetic peptide from the metalloproteinase propeptide: implications for an anti-angiogenic therapy. Oncol Res 6:251-257.
4. Boudreau N, Sympson CJ, Werb Z, Bissell MJ. 1995. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267:891-893.
5. 3.8-10 is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells. J Cell Physiol 176:206-215.
6. Brinckerhoff CE. 1991. Joint destruction in arthritis: metalloproteinases in the spotlight. Arthritis Rheum 34:1073-1075.
7. Chenard M-P, O'Siorain L, Shering S, Rouyer N, Lutz Y, Wolf C, Basset P, Bellocq J-P, Duffy MJ. 1996. High levels of stomelysin-3 correlate with poor prognosis in patients with breast carcinoma. Int J Cancer 69:448-451.
8. Chirivi RGS, Garofalo A, Crimmin MJ, Bawden LJ, Stoppacciaro A, Brown PD, Giavazzi R. 1994. Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor. Int J Cancer 58:460-464.
9. Darcy KM, Black JD, Hahm HA, Ip MM. 1991. Mammary organoids from immature virgin rats undergo ductal and alveolar morphogenesis when grown within a reconstituted basement membrane. Exp Cell Res 196:49-65.
10. Darcy KM, Shoemaker SF, Lee P-PH, Vaughan MM, Black JD, Ip MM. 1995a. Prolactin and epidermal growth factor regulation of the proliferation, morphogenesis, and functional differentiation of normal rat mammary epithelial cells in three dimensional primary culture. J Cell Physiol 163:346-364.
11. Darcy KM, Shoemaker SF, Lee P-PH, Ganis BA, Ip MM. 1995b. Hydrocortisone and progesterone regulation of the proliferation, morphogenesis, and functional differentiation of normal rat mammary epithelial cells in three dimensional primary culture. J Cell Physiol 163:365-379.
12. Darcy KM, Zangani D, Lee P-PH, Ip MM. 2000. Isolation and culture of normal rat mammary epithelial cells. In: Ip MM, Asch BB, editors. Methods in mammary gland biology and breast cancer research. New York: Kluwer Academic/Plenum Publishers, p 163-175.
13. Davies B, Brown PD, East N, Crimmin MJ, Balkwill FR. 1993. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res 53:2087-2091.
14. Dembinski TC, Shiu RPC. 1987. Growth factors in mammary gland and function. In: Neville MC, Daniel CW, editors. The mammary gland, development, regulation and function. New York-London: Plenum Publishing Corp. p 355-381.
15. Dickson SR, Warburton MJ. 1992. Enhanced synthesis of gelatinase and stromelysin by myoepithelial cells during involution of the rat mammary gland. J Histochem Cytochem 40:697-703.
16. Eccles SA, Box GM, Court WJ, Bone EA, Thomas W, Brown PD. 1996. Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94). Cancer Res 56:2815-2822.
17. Feng Z, Marti A, Jehn B, Altermatt HJ, Chicaiza G, Jaggi R. 1995. Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland. J Cell Biol 131:1095-1103.
18. Fridman R, Toth M, Pena D, Mobashery S. 1995. Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2). Cancer Res 55:2548-2555.
19. Hahm HA, Ip MM. 1990. Primary culture of normal rat mammary epithelial cells within a basement membrane matrix. I. Regulation of proliferation by hormones and growth factors. In Vitro Cell Dev Biol 26:791-802.
20. Hahm HA, Ip MM, Darcy K, Black JD, Shea WK, Forczek S, Yoshimura M, Oka T. 1990. Primary culture of normal rat mammary epithelial cells within a basement membrane matrix. II. Functional differentiation under serum-free conditions. In Vitro Cell Dev Biol 26:803-814.
21. Heppner KJ, Matrisian LM, Jensen RA, Rodgers WH. 1996. Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response. Am J Pathol 149:273-282.
22. Heussen C, Dowdle EB. 1980. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal Biochem 102:196-202.
23. Hewitt R, Dano K. 1996. Stromal cell expression of components of matrix-degrading protease systems in human cancer. Enzyme Protein 49:163-173.
24. Ip MM, Shoemaker SF, Darcy KM. 1992. Regulation of rat mammary epithelial cell proliferation and differentiation by tumor necrosis factor-α. Endocrinology 130:2833-2844.
25. Ip MM, Darcy KM. 1996. Three-dimensional mammary primary culture model systems. J Mammary Gland Biology 1:91-110.
26. Kerr LD, Olashaw NE, Matrisian LM. 1988. Transforming growth factor β1 and cAMP inhibit transcription of epidermal growth factor- and oncogene-induced transin RNA. J Biol Chem 263:16999-17005.
27. Kossakowska AE, Huchcroft SA, Urbanski SJ, Edwards DR. 1996. Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia, pulmonary carcinomas and malignant non-Hodgkin's lymphomas in humans. BrJ Cancer 73:1401-1408.
28. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
29. Lee P-PH, Darcy KM, Shudo K, Ip MM. 1995. Interaction of retinoids with steroid and peptide hormones in modulating morphological and functional differentiation of normal rat mammary epithelial cells. Endocrinology 136:1718-1730.
30. Lee P-PH, Hwang J-J, Mead L, Ip MM. 2000. Functional significance of MMP-9 in TNF-induced proliferation and branching morphogenesis of mammary epithelial cell. Endocrinology 141:3764-3773.
31. Lefebvre O, Wolf C, Limacher JM, Hutin P, Wending C, LeMeur M, Basset P, Rio MC. 1992. The breast cancer-associated stromelysin-3 gene is expressed during mouse mammary gland apoptosis. J Cell Biol 119:997-1002.
32. Lelongt B, Trugnan G, Murphy G, Ronco PM. 1997. Matrix metalloproteinases MMP2 and MMP9 are produced in early stages of kidney morphogenesis but only MMP9 is required for renal organogenesis in vitro. J Cell Biol 136:1363-1373.
33. Li F, Strange R, Friis RR, Djonov V, Altermatt H-J, Saurer S, Niemann H, Andres A-C. 1994. Expression of stromelysin-1 and TIMP-1 in the involuting mammary gland and in early invasive tumors of the mouse. Int J Cancer 59:560-568.
34. Liotta LA, Steeg PS, Stetler-Stevenson WG. 1991. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64:327-336.
35. Lochter A, Srebrow A, Sympson CJ, Terracio N, Werb Z, Bissell MJ. 1997. Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties. J Biol Chem 272:5007-5015.
36. Low JA, Johnson MD, Bone EA, Dickson RB. 1996. The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites formation in nude mice. Clin Cancer Res 2:1207-1214.
37. Lund LR, Rømer J, Thomasset N, Solberg H, Pyke C, Bissell MJ, Danø K, Werb Z. 1996. Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. Development 122:181-193.
38. MacPherson LJ, Bayburt EK, Capparelli MP, Carroll BJ, Goldstein R, Justice MR, Zhu L, Hu S-I, Melton RA, Fryer L, Goldberg RL, Doughty JR, Spirito S, Blancuzzi V, Wilson D, O'Byrne EM, Ganu V, Parker DT. 1997. Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. J Med Chem 40:2525-2532.
39. Matrisian LM. 1990. Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 6:121-125.
40. Mauviel A, Chung K-Y, Agarwal A, Tamai K, Uitto J. 1996. Cell-specific induction of distinct oncogenes of the Jun family is responsible for differential regulation of collagenase gene expression by transforming growth factor-β in fibroblasts and keratinocytes. J Biol Chem 271:10917-10923.
41. Mazzieri R, Masiero L, Zanetta L, Monea S, Onisto M, Garbisa S, Mignatti P. 1997. Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants. EMBO J 16:2319-2332.
42. Melchiori A, Albini A, Ray JM, Stetler-Stevenson WG. 1992. Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment. Cancer Res 52:2353-2356.
43. Murphy G, Knauper V. 1997. Relating matrix metalloproteinase structure to function: why the "hemopexin" domain? Matrix Biol 15:511-518.
44. Ossowski L, Biegel D, Reich E. 1979. Mammary plasminogen activator: correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue. Cell 16:929-940.
45. Park AJ, Matrisian LM, Kells AF, Pearson R, Yuan Z, Navre M. 1991. Mutational analysis of the transin (rat stromelysin) autoinhibitor region demonstrates a role for residues surrounding the "cysteine switch". J Biol Chem 266:1584-1590.
46. Polette M, Clavel C, Cockett M, Girod de Bentzmann S, Murphy G, Birembaut P. 1993. Detection and localization of mRNAs encoding matrix metalloproteinases and their tissue inhibitor in human breast pathology. Invasion Metastasis 13:31-37.
47. Russo J, Russo IH. 1987. Development of the human mammary gland. In: Neville MC, Daniel CW, editors. The mammary gland, development, regulation and function. New York-London: Plenum Publishing Corp. p 67-93.
48. Sehgal I, Thompson TC. 1999. Novel regulation of type IV collagenase (matrix metalloproteinase-9 and -2) activities by transforming growth factor-β1 in human prostate cancer cell lines. Mol Biol Cell 10:407-416.
49. Shea-Eaton WK, Lee P-PH, Ip MM. 2001. Regulation of milk protein gene expression in normal mammary epithelial cells by tumor necrosis factor. Endocrinology (in press).
50. Sledge GW Jr., Qulali M, Goulet R, Bone EA, Fife R. 1995. Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice. J Natl Cancer Inst 87:1546-1550.
51. Sreenath T, Matrisian LM, Stetler-Stevenson W, Gattoni-Celli S, Pozzatti RO. 1992. Expression of matrix metalloproteinase genes in transformed rat cell lines of high and low metastatic potential. Cancer Res 52:4942-4947.
52. Stetler-Stevenson WG, Krutzsch HC, Wacher MP, Margulies IMK, Liotta LA. 1989. The activation of human type IV collagenase proenzyme. J Biol Chem 264:1353-1356.
53. Stetler-Stevenson WG, Aznavoorian S, Liotta LA. 1993. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 9:541-573.
54. Streuli CH, Schmidhauser C, Bailey N, Yurchenco P, Skubitz AP, Roskelley C, Bissell MJ. 1995. Laminin mediates tissue-specific gene expression in mammary epithelia. J Cell Biol 129:591-603.
55. Sympson CJ, Talhouk RS, Alexander CM, Chin JR, Clift SM, Bissell MJ, Werb Z. 1994. Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J Cell Biol 125:681-693.
56. Talhouk RS, Chin JR, Unemori EN, Werb Z, Bissell MJ. 1991. Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture. Development 112:439-449.
57. Talhouk RS, Bissell MJ, Werb Z. 1992. Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution. J Cell Biol 118:1271-1282.
58. Tanaka H, Hojo K, Yoshida H, Yoshioka T, Sugita K. 1993. Molecular cloning and expression of the mouse 105-kDa gelatinase cDNA. Biochem Biophys Res Commun 190:732-740.
59. Vallee BL, Auld DS. 1990. Zinc coordination, function and structure of zinc enzymes and other proteins. Biochemistry 29:5647-5659.
60. Van Wart HE, Birkedal-Hansen H. 1990. The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proc Natl Acad Sci USA 87:5578-5582.
61. Wang X, Fu X, Brown PD, Crimmin MJ, Hoffman RM, 1994. Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res 54:4726-4728.
62. Witty JP, Wright JH, Matrisian LM. 1995. Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development. Mol Biol Cell 6:1287-1303.
63. Wolf C, Rouyer N, Lutz Y, Adida C, Loriot M, Bellocq J-P, Chambon P, Basset P. 1993. Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression. Proc Natl Acad Sci USA 90: 1843-1847.