Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studies

British Journal of Pharmacology

Volumn 118, Issue 4, 1996, Pages 871-878

  Kenny, B A ^a   Miller, A M ^a   Williamson, I J R ^a   O'Connell, J ^a   Chalmers, D H ^a   Naylor, A M ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

'Human prostate'; Adrenoceptor antagonists; Anaesthetized dog; 1 adrenoceptors

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 5!CHLORO 3 [2 [2 [2 (CYCLOPROPYLMETHOXY)PHENOXY]ETHYLAMINO] 2,2 DIMETHYLETHYL]INDOLE; 8 [3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]PROPYLCARBAMOYL] 3 METHYLFLAVONE; ALFUZOSIN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; DOXAZOSIN; INDORAMIN; NORADRENALIN; PHENYLEPHRINE; PRAZOSIN; SL 890591; SNAP 1069; TAMSULOSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AORTA; ARTERY CONSTRICTION; ARTICLE; BINDING AFFINITY; BLOOD PRESSURE; CONTROLLED STUDY; DOG; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTATE; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SMOOTH MUSCLE CONTRACTION;

EID: 0029779304     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15480.x     Document Type: Article

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