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Volumn 7, Issue 3, 2001, Pages 142-147

Antituberculosis drugs and new drug development

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; ETHAMBUTOL; ISOCITRATE LYASE; ISOCITRATE LYASE INHIBITOR; ISONIAZID; NITROIMIDAZOLE DERIVATIVE; NITROIMIDAZOPYRAN; OXAZOLIDINONE DERIVATIVE; PYRAZINAMIDE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; STREPTOMYCIN; THIOLACTOMYCIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

EID: 0035015670     PISSN: 10705287     EISSN: None     Source Type: Journal    
DOI: 10.1097/00063198-200105000-00005     Document Type: Review
Times cited : (11)

References (31)
  • 1
    • 0028889845 scopus 로고
    • Global epidemiology of tuberculosis: Morbidity and mortality of a worldwide epidemic
    • 1 Sinder Jr DE, Kochi A: Global epidemiology of tuberculosis: morbidity and mortality of a worldwide epidemic. J Am Med Assoc 1995, 273:220-226.
    • (1995) J Am Med Assoc , vol.273 , pp. 220-226
    • Sinder D.E., Jr.1    Kochi, A.2
  • 3
    • 0033925339 scopus 로고    scopus 로고
    • Tuberculosis in times of health sector reform
    • 3 Baris E: Tuberculosis in times of health sector reform. Int J Tuberc Lung Dis 2000, 4:595-596.
    • (2000) Int J Tuberc Lung Dis , vol.4 , pp. 595-596
    • Baris, E.1
  • 4
    • 0032821532 scopus 로고    scopus 로고
    • Studies on the treatment of tuberculosis undertaken by the British Medical Research Council Tuberculosis Units, 1946-1986, with relevant subsequent publications
    • 4 Fox W, Ellard GA, Mitchison DA: Studies on the treatment of tuberculosis undertaken by the British Medical Research Council Tuberculosis Units, 1946-1986, with relevant subsequent publications. Int J Tuberc Lung Dis 1999, 3:S231-S279. This is a comprehensive and complete coverage of the chronological developments in the chemotherapy of tuberculosis for four decades, starting from 1946. It also highlights the outstanding contributions made by the British Medical Research Council in the development of various treatment regimens for the management and treatment of tuberculosis.
    • (1999) Int J Tuberc Lung Dis , vol.3
    • Fox, W.1    Ellard, G.A.2    Mitchison, D.A.3
  • 7
    • 0034520818 scopus 로고    scopus 로고
    • New developments in the treatment of latent tuberculosis
    • 7 Chaisson RE: New developments in the treatment of latent tuberculosis, Int J Tuberc Lung Dis 2000, 4:S176-S181.
    • (2000) Int J Tuberc Lung Dis , vol.4
    • Chaisson, R.E.1
  • 10
    • 0035124613 scopus 로고    scopus 로고
    • The rationale for recommending fixed-dose combination tablets for treatment of tuberculosis
    • 10 Blomberg B, Spinaci S, Fourie B, et al.: The rationale for recommending fixed-dose combination tablets for treatment of tuberculosis, Bull WHO 2001, 79:61-68.
    • (2001) Bull WHO , vol.79 , pp. 61-68
    • Blomberg, B.1    Spinaci, S.2    Fourie, B.3
  • 11
    • 0032737204 scopus 로고    scopus 로고
    • Rifampicin bioavailability; a review of its pharmacology and the chemotherapeutic necessity for ensuring optimal absorption
    • 11 Ellard GA, Fourie PB: Rifampicin bioavailability; a review of its pharmacology and the chemotherapeutic necessity for ensuring optimal absorption, Int J Tuberc Lung Dis 1999, 3: S231-S279. This review mainly discusses the pharmacologic properties of rifampicin, with an emphasis on the need to establish the quality of rifampicin in marketed FDCs. It also highlights the number of volunteers, precision of analytic technique, and appropriate statistical test for the evaluation of rifampicin bioavailability from FDCs.
    • (1999) Int J Tuberc Lung Dis , vol.3
    • Ellard, G.A.1    Fourie, P.B.2
  • 13
    • 0033844326 scopus 로고    scopus 로고
    • In vitro activities of six fluoroquinolones against 250 clinical isolates of Mycobacterium tuberculosis susceptible or resistant to first-line antituberculosis drugs
    • 13 Ruiz-Serrano MJ, Alcalá L, Martinez L, et al.: In vitro activities of six fluoroquinolones against 250 clinical isolates of Mycobacterium tuberculosis susceptible or resistant to first-line antituberculosis drugs. Antimicrob Agents Chemother 2000, 44:2567-2568.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 2567-2568
    • Ruiz-Serrano, M.J.1    Alcalá, L.2    Martinez, L.3
  • 14
    • 0035138527 scopus 로고    scopus 로고
    • The role of fluoroquinolones in tuberculosis today
    • 14 Berning SE: The role of fluoroquinolones in tuberculosis today. Drugs 2001, 61:9-18.
    • (2001) Drugs , vol.61 , pp. 9-18
    • Berning, S.E.1
  • 15
    • 0032937732 scopus 로고    scopus 로고
    • In vitro and in vivo antimicrobial activities of T-381 1ME, a novel Des-F(6)-quinolone
    • 15 Takahata M, Mitsuyama J, Yamashiro Y, et al.: In vitro and in vivo antimicrobial activities of T-381 1ME, a novel Des-F(6)-quinolone. Antimicrob Agents Chemother 1999, 43:1077-1084.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 1077-1084
    • Takahata, M.1    Mitsuyama, J.2    Yamashiro, Y.3
  • 16
    • 0033011810 scopus 로고    scopus 로고
    • Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: Effects of a C-B methoxyl group on survival in liquid media and in human macrophage
    • 16 Zhao BY, Pine R, Domagala J, et al.: Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-B methoxyl group on survival in liquid media and in human macrophage. Antimicrob Agents Chemother 1999, 43:661-667.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 661-667
    • Zhao, B.Y.1    Pine, R.2    Domagala, J.3
  • 18
    • 0031879709 scopus 로고    scopus 로고
    • In vitro and in vivo activities of moxifloxacin and clinafloxacin against Mycobacterium tuberculosis
    • 18 Ji B, Lounis N, Maslo C, et al.: In vitro and in vivo activities of moxifloxacin and clinafloxacin against Mycobacterium tuberculosis. Antimicrob Agents Chemother 1998, 42:2066-2069.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 2066-2069
    • Ji, B.1    Lounis, N.2    Maslo, C.3
  • 19
    • 0034061875 scopus 로고    scopus 로고
    • Moxifloxacin: A review of its clinical potential in the management of community-acquired respiratory tract infections
    • 19 Barman Balfour JA, Lamb HM: Moxifloxacin: A review of its clinical potential in the management of community-acquired respiratory tract infections. Drugs 2000, 59:115-139.
    • (2000) Drugs , vol.59 , pp. 115-139
    • Barman Balfour, J.A.1    Lamb, H.M.2
  • 20
    • 0034058145 scopus 로고    scopus 로고
    • Oxazolidinones: A review
    • 20 Diekema DJ, Jones RN: Oxazolidinones: a review. Drugs 2000, 59:7-16.
    • (2000) Drugs , vol.59 , pp. 7-16
    • Diekema, D.J.1    Jones, R.N.2
  • 21
    • 13344284628 scopus 로고    scopus 로고
    • Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity
    • 21 Barbachyn MR, Hutchinson DK, Brickner SJ, et al.: Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity. J Med Chem 1996, 39:680-685.
    • (1996) J Med Chem , vol.39 , pp. 680-685
    • Barbachyn, M.R.1    Hutchinson, D.K.2    Brickner, S.J.3
  • 22
    • 0032960636 scopus 로고    scopus 로고
    • Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model
    • 22 Cynamon MH, Klemens SP, Sharpe CA, et al.: Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model. Antimicrob Agents Chemother 1999, 43:1189-1191.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 1189-1191
    • Cynamon, M.H.1    Klemens, S.P.2    Sharpe, C.A.3
  • 23
    • 0027411717 scopus 로고
    • In vitro and in vivo activities of nitroimidazole CGI 17341 against Mycobacterium tuberculosis
    • 23 Ashtekar DR, Costa-Perira R, Nagrajan K, et al.: In vitro and in vivo activities of nitroimidazole CGI 17341 against Mycobacterium tuberculosis. Antimicrob Agents Chemother 1993, 37:183-186.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 183-186
    • Ashtekar, D.R.1    Costa-Perira, R.2    Nagrajan, K.3
  • 24
    • 0029806578 scopus 로고    scopus 로고
    • Antimycobacterial action of thiolactomycin: An inhibitor of fatty acid and mycolic acid synthesis
    • 24 Slayden RA, Lee RE, Armour JW, et al.: Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis. Antimicrob Agents Chemother 1996, 40:2813-2819.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 2813-2819
    • Slayden, R.A.1    Lee, R.E.2    Armour, J.W.3
  • 25
    • 0034595879 scopus 로고    scopus 로고
    • Thiolactomycin and related analogues as novel antimycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis
    • 25 Kremer L, Douglas JD, Baulard AR, et al.: Thiolactomycin and related analogues as novel antimycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis. J Biol Chem 2000, 275:16857-16864.
    • (2000) J Biol Chem , vol.275 , pp. 16857-16864
    • Kremer, L.1    Douglas, J.D.2    Baulard, A.R.3
  • 26
    • 0034702247 scopus 로고    scopus 로고
    • A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
    • 26 Stover CK, Warrener P, van Devanter DR, et al.: A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. Nature 2000, 405:962-966. This paper reports a series of compounds belonging to the nitroimidazopyran nucleus having antituberculosis activity. Unlike the currently available drugs, these compounds were found to be bactericidal against the replicating and static M. tuberculosis with a novel mechanism of action that shares some similarity and contrasts with isoniazid.
    • (2000) Nature , vol.405 , pp. 962-966
    • Stover, C.K.1    Warrener, P.2    Van Devanter, D.R.3
  • 27
    • 0342794213 scopus 로고    scopus 로고
    • Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
    • 27 McKinney JD, Bentrup KH, Munõz-Elias EJ, et al.: Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature 2000, 406:735-738. The paper demonstrates for the first time that the persistence of M. tuberculosis in latent phase is facilitated by isocitrate lyase, an enzyme that is essential for metabolism of fatty acids. Furthermore, this paper emphasizes that the metabolism of M. tuberculosis in vitro is profoundly influenced by host response to infection. This finding opens up a new opportunity for treatment of latent cases.
    • (2000) Nature , vol.406 , pp. 735-738
    • McKinney, J.D.1    Bentrup, K.H.2    Munõz-Elias, E.J.3
  • 28
    • 0034713284 scopus 로고    scopus 로고
    • Biopharmaceutics and pharmacokinetics in drug research
    • 28 Panchagnula R, Thomas NS: Biopharmaceutics and pharmacokinetics in drug research, Int J Pharm 2000, 201:131-150. This review explains various biopharmaceutical hurdles in new drug development and approaches to overcoming them. The importance of solubility, permeability, and pharmacokinetic properties in new drug development is illustrated with suitable examples. Hence, this review gives a preamble to the current article.
    • (2000) Int J Pharm , vol.201 , pp. 131-150
    • Panchagnula, R.1    Thomas, N.S.2
  • 29
    • 0023947965 scopus 로고
    • Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985)
    • 29 Prentis RA, Lis Y, Walker SR: Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985), Br J Clin Pharmacol 1988, 25:387-396.
    • (1988) Br J Clin Pharmacol , vol.25 , pp. 387-396
    • Prentis, R.A.1    Lis, Y.2    Walker, S.R.3
  • 30
    • 0031734399 scopus 로고    scopus 로고
    • Oral drug delivery technology: Addressing the solubility/permeability paradigm
    • 30 Devane J: Oral drug delivery technology: addressing the solubility/permeability paradigm. Pharm Tech 1998, 68-80.
    • (1998) Pharm Tech , pp. 68-80
    • Devane, J.1
  • 31
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • 31 Llpinsky CA, Lombardo F, Dominy BW, et al.: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 1997, 23:3-25.
    • (1997) Adv Drug Deliv Rev , vol.23 , pp. 3-25
    • Llpinsky, C.A.1    Lombardo, F.2    Dominy, B.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.