Pterygia pathogenesis: Corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells

Archives of Ophthalmology

Volumn 119, Issue 5, 2001, Pages 695-706

  Dushku, Nicholas ^a   John, Molykutty K ^b   Schultz, Gregory S ^b   Reid, Ted W ^c  

^a KAISER PERMANENTE MEDICAL CENTER   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c TEXAS TECH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 15; STROMELYSIN; UNCLASSIFIED DRUG;

ARTICLE; BASAL CELL; BOWMAN MEMBRANE; CELL ACTIVATION; CONJUNCTIVA; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA LIMBUS; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PTERYGIUM; TISSUE DISTRIBUTION;

EID: 0035013667     PISSN: 00039950     EISSN: None     Source Type: Journal    
DOI: 10.1001/archopht.119.5.695     Document Type: Article

References (67)

1. Geographic distribution of pterygia
2. Corneal changes associated with chronic UV irradiation
3. Squamous cell carcinoma of the conjunctiva
4. Metastatic squamous cell carcinoma
5. Solar keratosis, pterygium, and squamous cell carcinoma of the conjunctiva in Malawi
6. Immunohistochemical evidence that pterygia arise from altered limbal epithelial basal stem cells
7. Immunohistochemical evidence that human pterygia originate from an invasion of vimentin-expressing altered limbal epithelial basal cells
8. Diseases of the outer eye
9. Dysgeneses, dystrophies and degenerations of the cornea
10. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma
11. Carcinogen specific mutational pattern in the p53 gene in ultraviolet B radiation-induced squamous cell carcinomas of mouse skin
12. Carcinogens leave fingerprints
13. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers
14. p53 Expression in altered limbal basal cells of pingueculae, pterygia and limbal tumors
15. Life (and death) in a malignant tumor
16. Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis
17. The use of PCR to test for human papilloma virus DNA in p53 expressing limbal stem cells of pinguecula, pterygia, and limbal tumors
18. p53 Expression and relation to HPV infection in pingueculae, pterygia and limbal tumors
19. Pterygia and limbal epithelial cells: Relationship and molecular mechanisms
20. Proteases and protease inhibitors in tissue repair
21. Increased expression of MMP-1 and MMP-3 by cultured pterygium head fibroblasts
22. Regulation of collagenase, stromelysin, and urokinase-type plasminogen activator in primary pterygium body fibroblasts by inflammatory cytokines
23. Tumor cell interactions with the extracellular matrix during invasion and metastasis
24. Matrix metalloproteinases and the development of cancer
25. Expression of must matrix metalloproteinase family members in breast cancer represents a tumor-induced host response
26. Expression of collagenase-related metalloproteinase genes in human lung or head and neck tumors
27. Production of matrix metalloproteinase-2 and metalloproteinase-3 related to malignant behavior of esophageal carcinoma: A clinicopathologic study
28. Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis
29. Changes in expression of matrix proteases and of the transcription factor c-Ets-1 during progression of precancerous bronchial lesions
30. MMP-2 and MMP-9 levels in pterygia and matched superior conlunctiva by gelatin zymography
31. Expression of MMPs and TIMPs in human pterygia and cultured pterygium epithelium cells
32. Pterygia pathogenesis: Corneal invasion by matrix metalloproteinase (MMP) expressing altered limbal basal stem cells and activation of fibroblasts
33. Matrix metalloproteinases and their inhibitors in gestational trophoblastic diseases and normal placenta
34. Detection of transforming growth factor-β messenger RNA and protein in human corneal epithelial cells
35. Matrix metalloproteinases in tissue repair
36. Matrix metalloproteinases and tissue inhibitors of metalloproteinases are expressed in human pterygia and cultured pterygium epithelial cells
37. Matrix metalloproteinases in epithelia from human recurrent corneal erosion
38. Immunolocalization of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human subconjunctival tissues
39. Membrane-type matrix metalloproteinases and cell surfaceassociated activation cascades for matrix metalloproteinases
40. Expression of gelatinase A and B, and TIMPS 1 and 2 during corneal wound healing
41. Matrix metalloproteinases are expressed during wound healing after excimer laser keratectomy
42. Immunohistochemical evidence that pterygia originate from Rb and TGFβ-expressing, p53 transformed, limbal basal stem cells
43. Immunohistochemical localization of basic fibroblast growth factor, platelet derived growth factor, transforming growth factor-β and tumor necrosis factor-α in the pterygium
44. Elevated expression of TGFβ and EGF system in pterygia tissues and matched superior conjunctiva
45. Elastodysplasia and elastodystrophy as the pathologic bases of ocular pterygia and pinguecula
46. Fibroblasts isolated from human pterygia exhibit transformed cell characteristics
47. Effects of ultraviolet irradiation on corneal epithelium: Mitosis, nuclear fragmentation, post-traumatic cell movements, loss of tissue cohesion
48. Pterygium as an early indicator of ultraviolet insulation: A hypothesis
49. Immunolocalization of TGFβ-1, TGFβ-2 and TGFβ-3 in the anterior segment of the human eye
50. Transforming growth factor type β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
51. Metastasis suppressor genes
52. Capillaries in the epithelium of pterygium
53. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
54. Indirect mitogenic effect of transforming growth factor-β on cell proliferation of subconjunctival fibroblasts
55. Cytokines modulate routes of collagen breakdown
56. Transforming growth factor-β1 up-regulates type IV collagenase expression in cultured human keratinocytes
57. Unique regulation of the matrix metalloproteinase, gelatinase B
58. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5
59. Immunogold fine structural localization of extracellular matrix components in aged human cornea, I types I-IV collagen and laminin